3D Bioprinted Skin Substitutes for Accelerated Wound Healing and Reduced Scar

Lian, Qin; Jiao, Tian; Zhao, Tingze; Wang, Huichao; Yang, Siming; Li, Dichen

doi:10.1007/s42235-021-0053-8

Cited by 15 publications

(10 citation statements)

References 57 publications

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“…For wound healing, this system has advantages due to the possibility of using the patient’s own plasma to be treated. Studies to obtain artificial skins manufactured in 3D can be performed using PAM with excellent physical and biological properties [ 145 ]. Bioprinted skin has enough characteristics to accelerate wound healing; and reduce contraction and formation of scars.…”

Section: D Printer/bioprinter In Wound Healingmentioning

confidence: 99%

“…Thus, new drugs and DSS may assist in the correct targeting of these fibroblasts during wound healing. For example, 3D-printed methacrylated gelatin and nanocellulose scaffolds, which improve healing while decreasing fibrosis and scarring, favoring cell proliferation of fibroblasts [ 76 , 145 , 166 , 167 ]. These proliferation activities can be improved by incorporating active compounds into printing inks such as HA and growth factors [ 168 ].…”

Section: D-printed Materials At Different Stages Of Wound Healingmentioning

confidence: 99%

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3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Uchida

Bruschi

2023

AAPS PharmSciTech

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Wound healing is a dynamic process which involves stages of hemostasis, inflammation, proliferation and remodeling. Any error in this process results in abnormal wound healing, generating financial burdens for health systems and even affecting the physical and mental health of the patient. Traditional dressings do not meet the complexities of ideal treatment in all types of wounds. For this reason, in the last decades, different materials for drug delivery and for the treatment of wounds have been proposed reaching novel level of standards, such as 3D printing techniques. The use of natural or synthetic polymers, and the correct design of these printed products loaded with cells and/or combined with active compounds, can generate an effective system for the treatment of wounds, improving the healing process and generating customized dressings according to the patient needs. This manuscript provides a comprehensive review of different types of 3D printing techniques, as well as its use in wound healing and its different stages, including the advantages and limitations of additive manufacturing and future perspectives. Graphical abstract

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Section: D Printer/bioprinter In Wound Healingmentioning

confidence: 99%

Section: D-printed Materials At Different Stages Of Wound Healingmentioning

confidence: 99%

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Uchida

Bruschi

2023

AAPS PharmSciTech

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“…Problems of skin scarring and reduced wound contraction with accelerated wound healing were demonstrated using a gelatin/sodium alginate/gelatin methacrylate bioprinter supplemented with normal human dermal fibroblasts (NHDF) and normal human epidermal keratinocytes (NHEK) to print the dermis and epidermis. The results showed accelerated epithelialization as well as the absence of scarring [ 158 ]. The multilayer hydrogel material gelatin/SA/GelMA had a high elongation at break, so the authors of the study suggest that the risks of tearing caused by the wound activity in the grafted skin are minimal ( Table 7 ).…”

Section: Biomedical Application Of Bilayer Hydrogelsmentioning

confidence: 99%

Bilayer Hydrogels for Wound Dressing and Tissue Engineering

2022

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A large number of different skin diseases such as hits, acute, and chronic wounds dictate the search for alternative and effective treatment options. The wound healing process requires a complex approach, the key step of which is the choice of a dressing with controlled properties. Hydrogel-based scaffolds can serve as a unique class of wound dressings. Presented on the commercial market, hydrogel wound dressings are not found among proposals for specific cases and have a number of disadvantages—toxicity, allergenicity, and mechanical instability. Bilayer dressings are attracting great attention, which can be combined with multifunctional properties, high criteria for an ideal wound dressing (antimicrobial properties, adhesion and hemostasis, anti-inflammatory and antioxidant effects), drug delivery, self-healing, stimulus manifestation, and conductivity, depending on the preparation and purpose. In addition, advances in stem cell biology and biomaterials have enabled the design of hydrogel materials for skin tissue engineering. To improve the heterogeneity of the cell environment, it is possible to use two-layer functional gradient hydrogels. This review summarizes the methods and application advantages of bilayer dressings in wound treatment and skin tissue regeneration. Bilayered hydrogels based on natural as well as synthetic polymers are presented. The results of the in vitro and in vivo experiments and drug release are also discussed.

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“…The addition of fibroblast growth factor might improve the treatment effectiveness. In turn, Lian et al 118 added to hydrogel (that contained gelatin, sodium alginate, gelatin methacrylate) normal human dermal fibroblasts and normal human keratinocytes to fabricate a skin substituent that was applied to reduce scars in nude mice. The bioprinted skin revealed much better results in healing the wound than the bioprinted hydrogel or untreated wound control.…”

Section: Application Of 3d Bioprinting In Skin-related Researchmentioning

confidence: 99%

3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives

et al. 2021

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In recent years, significant progress has been observed in the field of skin bioprinting, which has a huge potential to revolutionize the way of treatment in injury and surgery. Furthermore, it may be considered as an appropriate platform to perform the assessment and screening of cosmetic and pharmaceutical formulations. Therefore, the objective of this paper was to review the latest advances in 3D bioprinting dedicated to skin applications. In order to explain the boundaries of this technology, the architecture and functions of the native skin were briefly described. The principles of bioprinting methods were outlined along with a detailed description of key elements that are required to fabricate the skin equivalents. Next, the overview of recent progress in 3D bioprinting studies was presented. The article also highlighted the potential applications of bioengineered skin substituents in various fields including regenerative medicine, modeling of diseases, and cosmetics/drugs testing. The advantages, limitations, and future directions of this technology were also discussed.

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3D Bioprinted Skin Substitutes for Accelerated Wound Healing and Reduced Scar

Cited by 15 publications

References 57 publications

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Bilayer Hydrogels for Wound Dressing and Tissue Engineering

3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives

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