Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells

Marchetti, Sara; Mollerup, Steen; Gützkow, Kristine B.; Rizzi, C.; Skuland, Tonje; Refsnes, Magne; Colombo, A; Øvrevik, Johan; Mantecca, Paride; Holme, Jørn A.

doi:10.1016/j.tiv.2021.105190

Cited by 4 publications

(1 citation statement)

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“…Pollutants such as PAHs cause DNA adducts and epigenetic modification [54]. In vitro, combustion-derived particles from wood-burning alter cell proliferation and cause DNA damage, suggesting these particles are involved in early cancer development [55]. Chronic exposure to PM 2.5 enhances invasion in lung adenocarcinoma cell lines and promotes tumorigenesis and metastasis in patient-derived xenograft models [56].…”

Section: Mechanisms Of Lung Injury From Wildfire Smoke Exposurementioning

confidence: 99%

Clearing the Air: Understanding the Impact of Wildfire Smoke on Asthma and COPD

Wilgus,

Merchant

2024

Healthcare

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Wildfires are a global natural phenomenon. In North America, wildfires have not only become more frequent, but also more severe and longer in duration, a trend ascribed to climate change combined with large fuel stores left from modern fire suppression. The intensification of wildfire activity has significant implications for planetary health and public health, as exposure to fine particulate matter (PM2.5) in wildfire smoke is linked to adverse health effects. This review focuses on respiratory morbidity from wildfire smoke exposure. Inhalation of wildfire PM2.5 causes lung injury via oxidative stress, local and systemic inflammation, airway epithelium compromise, and increased vulnerability to infection. Wildfire PM2.5 exposure results in exacerbations of pre-existing asthma and chronic obstructive pulmonary disease, with an escalation in healthcare utilization, including emergency department visits and hospitalizations. Wildfire smoke exposure may be associated with asthma onset, long-term impairment of lung function, and increased all-cause mortality. Children, older adults, occupationally-exposed groups, and possibly women are the most at risk from wildfire smoke. Future research is needed to clarify best practices for risk mitigation and wildfire management.

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Section: Mechanisms Of Lung Injury From Wildfire Smoke Exposurementioning

confidence: 99%