A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis

Wang, Kang‐Nan; Liu, Liu‐Yi; Mao, Duo; Xu, Shidang; Tan, Cai‐Ping; Cao, Qian; Mao, Zong‐Wan; Liu, Bin

doi:10.1002/anie.202104163

Cited by 227 publications

(150 citation statements)

References 48 publications

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“…All reagents and organic solvents were purchased from commercial suppliers and used without further purification. 1 H NMR spectra of compounds were recorded on a Bruker 600 MHz instrument (Bruker AVANCE NEO, Bruker, Karlsruhe, Germany). Fluorescence spectra were carried out by a Hitachi F-4600 fluorescence spectrometer (Hitachi, Tokyo, Japan).…”

Section: Apparatus and Reagentsmentioning

confidence: 99%

“…(Figure 9c). When the fluorescence intensity is higher than the threshold, the output signal is on (1). Additionally, when the fluorescence intensity is below the threshold, the output signal is off (0).…”

Section: Visual Detection Of Cu 2+ In Solid Statementioning

confidence: 99%

“…Additionally, when the fluorescence intensity is below the threshold, the output signal is off (0). Based on the above basic logic gate, when both Cu 2+ and EDTA are present or absent, the output signal is on (1). When In 1 and In 2 are in the state (1, 0), the output signal is off (0).…”

Section: Visual Detection Of Cu 2+ In Solid Statementioning

confidence: 99%

“…The following are available online at https://www.mdpi.com/article/ 10.3390/polym13183091/s1, Figure S1. 1 H NMR spectrum of CPBI 0 ; Figure S2. 1 H NMR spectrum of CPBI 1 ; Figure S3.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Conjugated polymer molecules are important materials for optoelectronic applications because they provide a relatively direct link between optoelectronic properties and compound structures [1]. Compared with non-backbone conjugated polymeric probes, organic backbone conjugated polymers are composed of unsaturated structural units, such as aromatic hydrocarbons, olefins, or acetylene, making the formation of a large delocalized polarizable π-electronic domain easy [2].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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A new type of conjugated polybenzimidazole (CPBI) was synthesized through a simple polycondensation reaction without metal catalysis, and N-alkylation modification was carried out to solve the problems of solubility and fluorescence properties. A series of nano-microsphere polymers CPBIn with large conjugation, good solubility, and strong fluorescence has been successfully used as “turn-off” fluorescent probes for the first time. The results show that, under suitable N-alkylation conditions, the obtained CPBIn can be used as a highly sensitive and selective fluorescent probe for the detection of Cu2+ and Zn2+ at the same time, and their detection limits are both nM levels. In addition, CPBI2 can be designed as an ultra-sensitive IMPLICATION logic gate at the molecular level, cyclically detecting Cu2+. With the test paper containing CPBI2, easy and quick on-site detection can be achieved. This research provides a new idea for the brief synthesis of multifunctional materials.

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Section: Apparatus and Reagentsmentioning

confidence: 99%

Section: Visual Detection Of Cu 2+ In Solid Statementioning

confidence: 99%

Section: Visual Detection Of Cu 2+ In Solid Statementioning

confidence: 99%

“…The following are available online at https://www.mdpi.com/article/ 10.3390/polym13183091/s1, Figure S1. 1 H NMR spectrum of CPBI 0 ; Figure S2. 1 H NMR spectrum of CPBI 1 ; Figure S3.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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Methods to Control the Subcellular Localisation of Fluorescent Sensors

Lin¹,

Yang²,

New³

2022

Molecular Fluorescent Sensors for Cellular Studies

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Ultrabright and Highly Polarity‐Sensitive NIR‐I/NIR‐II Fluorophores for the Tracking of Lipid Droplets and Staging of Fatty Liver Disease

Zhou

Zhang

Yang

et al. 2021

Adv Funct Materials

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Visualizing the progression of fatty liver disease in vivo is of great significance in biomedical research of fatty liver, but hindered by the lack of suitable approaches with deep penetration, high specificity, and real-time observability for fatty liver imaging. Herein, two bright NIR-I/NIR-II fluorophores with D-π-A-π-D structures are designed and synthesized for fatty liver tracking in vivo. Such fluorophores show an ultrahigh quantum yield of 49.2% and 17.3% at the emission maximum of 930 and 975 nm, respectively. Most interestingly, these two fluorophores display ultrasensitive fluorescence response (over 100-fold enhancement) toward the variations of environment polarity. Accordingly, further doping of these fluorophores into amphiphilic organic matrix allows the formation of ultrabright NIR-I/NIR-II fluorescent nanoprobes for high-resolution fluorescence imaging of the vessels. Additionally, with the assistance of such nanoprobes and NIR-II fluorescence imaging, real-time monitoring of heartbeat rate and the respiratory rate, accurate identification, and imaging-guided surgery of the submillimeter scale lymph nodes are successfully realized. Moreover, the as-designed fluorophores show superior performance for indicating lipid droplets (LDs) in living cells. Ultimately, precise monitoring of fatty liver with NIR-I/NIR-II fluorescent LDs probe is first confirmed, demonstrating the possibility for staging fatty liver disease with a contact-free method.

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A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis

Cited by 227 publications

References 48 publications

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

Methods to Control the Subcellular Localisation of Fluorescent Sensors

Ultrabright and Highly Polarity‐Sensitive NIR‐I/NIR‐II Fluorophores for the Tracking of Lipid Droplets and Staging of Fatty Liver Disease

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