Ovomucoid‐specific IgD increases in children who naturally outgrow egg allergy in a cross‐sectional study

Abstract

We thank Ms. Michiyo Toyooka and Ms. Yuki Mori for their assistance in carrying out Ig measurement.

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

“…In summary, we have characterized a hitherto elusive subset of tonsillar IgD-ME B cells that serves as a ready-to-use IgD-PC reservoir for steady-state nasopharyngeal IgD responses. Considering recently published data ( 43–46 ), we propose that specificities resulting from IgD responses acquire polyreactivity to common aerodigestive antigens, including commensal, food and airborne antigens, via a mutation-dependent program designed to enhance mucosal tolerance.…”

“…Considering recently published data (43)(44)(45)(46), we propose that specificities resulting from IgD responses acquire polyreactivity to common aerodigestive antigens, including commensal, food and airborne antigens, via a mutation-dependent program designed to enhance mucosal tolerance.…”

“…Besides broadening our understanding of humoral responses to potential allergens such as common food and airborne proteins (42), this advance could facilitate the development of novel prognostic tools and therapeutic strategies for allergic disorders. Indeed, allergic children with robust allergen-specific IgD responses show a lower risk of anaphylaxis and increased likelihood of naturally outgrowing allergy (43,44). Increased IgD responses to allergens are also associated with desensitization or even sustained tolerance in allergic patients treated with oral immunotherapy (44)(45)(46).…”