The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases

Itoh, Naohiro; Ohshima, Yusei

doi:10.1016/j.alit.2022.09.004

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…IgD-PCs were described more than two decades ago ( 13 ), but their ontogeny, regulation, clonal architecture, and reactivity to common nasopharyngeal antigens remain poorly characterized. Clarifying these properties may help understand the role of nasopharyngeal IgD responses in immune tolerance as well as inflammation ( 40 , 41 ). Besides broadening our understanding of humoral responses to potential allergens such as common food and airborne proteins ( 42 ), this advance could facilitate the development of novel prognostic tools and therapeutic strategies for allergic disorders.…”

Section: Discussionmentioning

confidence: 99%

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

Tachó-Piñot,

Bashour,

Filipska

et al. 2023

Preprint

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The human nasopharyngeal mucosa includes organized lymphoepithelial structures continually engaged in frontline immune responses to aerodigestive antigens. Advancing our understanding of these responses might lead to the development of new strategies for the prevention and treatment of common immune disorders such as allergies. Here we identified a hitherto elusive tonsillar subset of atypical IgD class-switched IgD+IgM-memory (IgD-ME) B cells that were clonally related to IgD+IgM−germinal center (IgD-GC) B cells and IgD-secreting IgD+IgM−plasma cells (IgD-PCs) but not anergic IgD+IgM−B cells. Consistent with their pre-plasmacellular properties, IgD-ME B cells served as preferential precursors of IgD-PCs over IgD-GC B cells. IgD antibodies from IgD+IgM−cells acquired reactivity to multiple oral, airborne and commensal antigens through a mutation-dependent pathway involving both innate and adaptive signals. Thus, IgD-ME B cells may form a ready-to-use pre-plasmacellular reservoir for steady-state IgD responses likely aimed at enhancing nasopharyngeal homeostasis.One Sentence SummaryTonsillar atypical memory B cells form a ready-to-use pre-plasmacellular repertoire for IgD responses to common aerodigestive antigens.

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Section: Discussionmentioning

confidence: 99%

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

Tachó-Piñot,

Bashour,

Filipska

et al. 2023

Preprint

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“…For many decades, the functions of secreted IgD, first described in 1965 [13], remained largely unknown. However, recently emerging roles have been identified for secreted IgD in mucosal immunity [14] and allergic disease [15]. The crystal structure of the HAPPID1 Fab has recently been solved, allowing the first high-resolution analysis of the unique Cδ1 domain [16].…”

Section: Introductionmentioning

confidence: 99%

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor

Vester,

Davies,

Beavil

et al. 2023

Antibodies

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We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In this work, we complete the toolkit of human antibody isotypes with the IgD version of the anti-Phl p 7 monoclonal antibody. We also raised a set of nanobodies against the IgD anti-Phl p 7 antibody and identify and characterize one paratope-specific nanobody. This nanobody also binds to the IgE isotype of this antibody, which shares the same idiotype, and orthosterically inhibits the interaction with Phl p 7. The 2.1 Å resolution X-ray crystal structure of the nanobody in complex with the IgD Fab is described.

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Intestinal barrier immunity: key players in the gut microbial “meet and greet or get-rid” event

Bhattacharjee

2024

Microbes, Microbial Metabolism, and Mucosal Immunity

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The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases

Cited by 3 publications

References 50 publications

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor

Intestinal barrier immunity: key players in the gut microbial “meet and greet or get-rid” event

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