Antibody-mediated regulation of basophils: emerging views and clinical implications

Chen, Kang; Hao, Yujing; Guzmán, Mauricio; Li, Genxia; Cerutti, Andrea

doi:10.1016/j.it.2023.04.003

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Cited by 7 publications

References 114 publications

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β-lactoglobulin hydrolysates by L.plantarum AHQ-14 and L.bulgaricus BD0390 alleviate allergic responses to β-lactoglobulin in sensitized mice

Jiang,

Meng

et al. 2024

Food Bioscience

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β-lactoglobulin hydrolysates by L.plantarum AHQ-14 and L.bulgaricus BD0390 alleviate allergic responses to β-lactoglobulin in sensitized mice

Jiang,

Meng

et al. 2024

Food Bioscience

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Basophil differentiation, heterogeneity, and functional implications

Chen,

Tang,

Yao

et al. 2024

Trends in Immunology

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Unveiling the influence of circulating immune cells count on type 1 diabetes: Insight from bidirectional Mendelian randomization

Luo,

Wang,

Xiang

et al. 2024

Medicine

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Observational studies have demonstrated an association between circulating immune cell and type 1 diabetes (T1D) risk. However, it is unknown whether this relationship is causal. Herein, we adopted a 2-sample bidirectional Mendelian randomization study to figure out whether circulating immune cell profiles causally impact T1D liability. Summary statistical data were obtained from genome-wide association study (GWAS) to investigate the causal relationship between white cell (WBC) count, 5 specific WBC count, and lymphocyte subtypes cell count and T1D risk. After false discovery rate (FDR) correction, the results indicated that lower lymphocyte cell count (odds ratio [OR] per 1 standard deviation [SD] decrease = 0.746, 95% confidence interval (CI): 0.673–0.828, P FDR = 0.036), and basophil cell count (OR per 1 SD decrease = 0.808, 95% CI: 0.700–0.932, P FDR = 0.010) were causally associated with T1D susceptibility. However, the absolute count of WBC, monocyte, neutrophil, eosinophil, and lymphocyte subtypes cell had no statistically significant effect on T1D risk. Taken together, this study indicates suggestive association between circulating immune cell count and T1D. Moreover, lower numbers of circulating lymphocyte and basophil cell were associated with the increased risk of T1D, which confirmed the immunity predisposition for T1D.

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Antibody-mediated regulation of basophils: emerging views and clinical implications

Cited by 7 publications

References 114 publications

β-lactoglobulin hydrolysates by L.plantarum AHQ-14 and L.bulgaricus BD0390 alleviate allergic responses to β-lactoglobulin in sensitized mice

β-lactoglobulin hydrolysates by L.plantarum AHQ-14 and L.bulgaricus BD0390 alleviate allergic responses to β-lactoglobulin in sensitized mice

Basophil differentiation, heterogeneity, and functional implications

Unveiling the influence of circulating immune cells count on type 1 diabetes: Insight from bidirectional Mendelian randomization

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