2021
DOI: 10.1017/jfm.2020.1162
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The effect of viscoelasticity in an airway closure model

Abstract: Abstract

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Cited by 19 publications
(22 citation statements)
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References 74 publications
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“…(2019) used a volume-of-fluid method to model the pre- and post-coalescence phases of Newtonian plug formation, and recently extended this work to include the effect of viscoelasticity (Romanò et al. 2021). They found that post-coalescence bi-frontal plug growth can induce significant stresses on the tube wall, and that viscoelasticity can induce additional wall stress due to the occurrence of an elastic instability.…”
Section: Introductionmentioning
confidence: 99%
“…(2019) used a volume-of-fluid method to model the pre- and post-coalescence phases of Newtonian plug formation, and recently extended this work to include the effect of viscoelasticity (Romanò et al. 2021). They found that post-coalescence bi-frontal plug growth can induce significant stresses on the tube wall, and that viscoelasticity can induce additional wall stress due to the occurrence of an elastic instability.…”
Section: Introductionmentioning
confidence: 99%
“…2011; Romanò et al. 2019, 2021). These repeated and high stresses are a potential source of injury for the epithelial cells lining the airway wall (Kay et al.…”
Section: Introductionmentioning
confidence: 99%
“…In a similar setting, Romanò et al. (2021) modelled the one-layer liquid as an Oldroyd-B fluid and illustrated the effects of the viscoelasticity on airway closure. They observed a second peak of the wall shear stresses that can be as high as the first one after the coalescence due to an elasto-inertial instability.…”
Section: Introductionmentioning
confidence: 99%
“…The airways in the LRT of the adult lung has approximately 23 generations of bifurcations with the trachea being the zeroth generation and the terminal bronchioles number 23. In the LRT, the ASL has two distinct layers depending on the generation: (i) a complex hydrogel mucus layer that is directly exposed to the inhaled/exhaled air and acts as a clearance vehicle and protective barrier against foreign particles and pathogens (up to generation [15][16], and (ii) a periciliary fluid-like layer in which the cilia beat and which up to generation 15-16 is below the first layer (for generation >17 only the periciliary fluid-like layer remains) [e.g., see 33,34]. The primary component of the overall ASL in healthy humans is water, with a nonvolatile solid fraction of approximately 1.1-2.3% wt [35,36].…”
mentioning
confidence: 99%