Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems

Fu, Yupeng; Ding, Ying; Zhang, Litao; Zhang, Yongmin; Liu, Jiang; Yu, Peng

doi:10.1016/j.ejmech.2021.113372

Cited by 38 publications

(18 citation statements)

References 163 publications

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“…PEG has been applied in plenty of delivery systems such as micelles, vesicles, nanoparticles and hydrogels. 67 For example, Chen et al devised biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles which achieved the slow release of hydrophobic therapeutic agents. 68 Yusuf Haggag et al prepared nanoparticles consisting of PLGA-PEG polymers to exhibit insulin sustainable release behaviors.…”

Section: Resultsmentioning

confidence: 99%

Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

Tang

Xie

Zhu

et al. 2022

IJN

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Section: Resultsmentioning

confidence: 99%

Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

Tang

Xie

Zhu

et al. 2022

IJN

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“…Polyethylene glycol (PEG) is composed of repeating oxyethylene subunits. It is one of the most commonly used synthetic macromolecular polymers for modifying drugs with various molecular weight or NDDSs to improve their water solubility, stability and biocompatibility (Fu et al, 2021). Furthermore, block copolymers containing polyethylene glycol such as Polyethylene glycol-Poly lactic acid (PEG-PLA), Polyethylene glycol-Poly caprolactone (PEG-PCL), Poloxamer, Polyethylene glycol-poly lactic-co-glycolic acid (PEG-PLGA), and Polyethylene glycol -distearoyl-sn-glycero-3-phosphoethanolamine (PEG-DSPE) have been commonly used as pharmaceutical excipients in the preparation of solid lipid nanoparticles, polymeric micelles, polymeric nanoparticles and liposomes (Owens and Peppas, 2006;Markovsky et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

et al. 2022

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Polyethylene glycol is one of the most commonly used synthetic macromolecular polymers for modifying small molecule drugs, peptides, proteins or Nano-drug delivery systems to improve their water solubility, biocompatibility and stability.Block copolymers containing PEG have been widely used in Nano-drug delivery systems such as solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles and liposomes. To date, although numerous PEGylated Nano-drug delivery systems have been developed, only a few have been approved for clinical application.Poor safety and effectivity are important reasons for the high failure of Nano-drug delivery systems clinical trials. These factors are not only related to the loaded drugs and released drugs, but also related to the nanocarriers. Therefore, investigating the in vivo spatiotemporal fate of block copolymers containing PEG used in Nano-drug delivery systems is necessary and important for evaluating their safety, efficacy and toxicity. In this article, we will review the information that has been reported about the absorption, distribution, metabolism and excretion of block copolymers containing PEG. We believe this review is helpful to understand the biological fate of block copolymers containing PEG.

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“…Mesoporous silica nanoparticles (MSN NPs) have attracted increased attention as potential drug carriers for biomedical applications [ 30 , 31 ]. Inorganic nanomaterials have higher physicochemical stability and versatility but lower biocompatibility and biodegradability than organic nanomaterials [ 32 , 33 ]. Therefore, the construction of an organic/inorganic hybrid material nanoplatform should combine the advantages of both modalities whilst mitigating their respective shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Zhou

et al. 2021

J Nanobiotechnol

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Background Hepatocellular carcinoma is insensitive to many chemotherapeutic agents. Ferroptosis is a form of programmed cell death with a Fenton reaction mechanism. It converts endogenous hydrogen peroxide into highly toxic hydroxyl radicals, which inhibit hepatocellular carcinoma progression. Methods The morphology, elemental composition, and tumour microenvironment responses of various organic/inorganic nanoplatforms were characterised by different analytical methods. Their in vivo and in vitro tumour-targeting efficacy and imaging capability were analysed by magnetic resonance imaging. Confocal microscopy, flow cytometry, and western blotting were used to investigate the therapeutic efficacy and mechanisms of complementary ferroptosis/apoptosis mediated by the nanoplatforms. Results The nanoplatform consisted of a silica shell doped with iron and disulphide bonds and an etched core loaded with doxorubicin that generates hydrogen peroxide in situ and enhances ferroptosis. It relied upon transferrin for targeted drug delivery and could be activated by the tumour microenvironment. Glutathione-responsive biodegradability could operate synergistically with the therapeutic interaction between doxorubicin and iron and induce tumour cell death through complementary ferroptosis and apoptosis. The nanoplatform also has a superparamagnetic framework that could serve to guide and monitor treatment under T2-weighted magnetic resonance imaging. Conclusion This rationally designed nanoplatform is expected to integrate cancer diagnosis, treatment, and monitoring and provide a novel clinical antitumour therapeutic strategy. Graphical Abstract

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Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems

Cited by 38 publications

References 163 publications

Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

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