The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

Yin, Lei; Pang, Yiling; Shan, Lin; Gu, Jian

doi:10.1124/dmd.121.000568

Cited by 16 publications

(12 citation statements)

References 91 publications

(95 reference statements)

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“…PEG has been used as a medical material for a long time. PEG-based materials are the most well-known DDS carriers made of PEG [ 68 , 69 , 70 ]. They can improve blood retention and enhance drug efficacy, but are not biodegradable or cell-adhesive.…”

Section: Hydrogel and Artificial Cell Sheetsmentioning

confidence: 99%

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Miyamoto

2023

Gels

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Organ transplantation is the first and most effective treatment for missing or damaged tissues or organs. However, there is a need to establish an alternative treatment method for organ transplantation due to the shortage of donors and viral infections. Rheinwald and Green et al. established epidermal cell culture technology and successfully transplanted human-cultured skin into severely diseased patients. Eventually, artificial cell sheets of cultured skin were created, targeting various tissues and organs, including epithelial sheets, chondrocyte sheets, and myoblast cell sheets. These sheets have been successfully used for clinical applications. Extracellular matrix hydrogels (collagen, elastin, fibronectin, and laminin), thermoresponsive polymers, and vitrified hydrogel membranes have been used as scaffold materials to prepare cell sheets. Collagen is a major structural component of basement membranes and tissue scaffold proteins. Collagen hydrogel membranes (collagen vitrigel), created from collagen hydrogels through a vitrification process, are composed of high-density collagen fibers and are expected to be used as carriers for transplantation. In this review, the essential technologies for cell sheet implantation are described, including cell sheets, vitrified hydrogel membranes, and their cryopreservation applications in regenerative medicine.

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Section: Hydrogel and Artificial Cell Sheetsmentioning

confidence: 99%

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Miyamoto

2023

Gels

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“…Due to their non‐immunogenic and non‐antigenic properties, PEG polymers have been approved by the Food and Drug Administration (FDA) for pharmaceutical applications [6–8]. The favorable properties of PEG polymers have facilitated their applications in drug delivery systems to improve their water solubility and prolong their half‐life in vivo [9–13]. Investigations of the cellular toxicity and pharmacokinetic behavior of PEG are needed and helpful for revealing the efficiency and toxicity of PEGylated drug delivery systems in preclinical and clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐high‐performance liquid chromatography with tandem mass spectrometry method for cellular toxicity and pharmacokinetic study of PEG1K polymers

Ge,

Zhang,

Zheng

et al. 2024

J of Separation Science

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Polyethylene glycol (PEG) is one of the most commonly used polymers in drug delivery systems. The investigation of the pharmacokinetic behavior of PEG is important for revealing the toxicity and efficiency of PEG‐related Nano‐drug delivery systems. A high through‐put and selective ultra‐high‐performance liquid chromatography with tandem mass spectrometry (UHPLC‐MS/MS) method coupled with collision‐induced dissociation (CID) in source technique was developed and validated to determine PEG1K polymers in cellular samples in this study. The countless precursor ions of PEG1K are dissociated in the source to generate numerous product ions which have different numbers of subunits. The transition of [M+H]+ precursor ions → product ions at m/z 177.1 (four subunits)→89.1 (two subunits) was selected to determine PEG1K due to its high sensitivity. The UHPLC‐MS/MS method coupled with CID in the source showed good linearity over the range of 0.1–10 μg/mL. Intra‐day and inter‐day accuracies and precisions of the assay were all within ± 12.39%. The assay was successfully applied to a cellular pharmacokinetic study of PEG1K in human breast cancer cells. The cytotoxicity of PEG1K polymers was also studied and the results indicated that the cytotoxicity of PEG1K was not significant in the range of 5–1200 μg/mL.

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“…The ultimate goal is to bring forth more innovative and effective solutions for the treatment of hyperlipidemia. 12 Polymeric micelles offer significant advantages, including improved aqueous solubility 13 and stability of challenging drugs, extended drug half-life, and effective transcellular and intracellular drug delivery. 14 Due to their ease of preparation and modification, polymeric carriers are widely used in the development of nanodrug carriers, which can be broadly categorized into liposomes, 15 polymeric microspheres, 16−18 and polymeric micelles.…”

Section: ■ Introductionmentioning

confidence: 99%

“…This has prompted current research to focus on polymeric nanomedicine carriers, aiming to enhance the water solubility and stability of insoluble drugs. The ultimate goal is to bring forth more innovative and effective solutions for the treatment of hyperlipidemia …”

Section: Introductionmentioning

confidence: 99%

Hybrid Microneedle-Mediated Transdermal Delivery of Atorvastatin Calcium-Loaded Polymeric Micelles for Hyperlipidemia Therapy

Ou Yang,

Hu,

Feng

et al. 2024

ACS Appl. Bio Mater.

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Hyperlipidemia has been a huge challenge to global health, leading to the cardiovascular disease, hypertension, and diabetes. Atorvastatin calcium (AC), a widely prescribed drug for hyperlipidemia, faces huge challenges with oral administration due to poor water solubility and hepatic first-pass effects, resulting in low therapeutic efficacy. In this work, we designed and developed a hybrid microneedle (MN) patch system constructed with soluble poly(vinyl alcohol) (PVA) and AC-loaded polymeric micelles (AC@PMs) for transdermal delivery of AC to enhance the hyperlipidemia therapy. We first prepared various AC@PM formulations self-assembled from mPEG–PLA and mPEG–PLA-PEG block copolymers using a dialysis method and evaluated the physicochemical properties in combination with experiment skills and dissipative particle dynamics (DPD) simulations. Then, we encapsulated the AC@PMs into the PVA MN patch using a micromold filling method, followed by characterizing the performances, especially the structural stability, mechanical performance, and biosafety. After conducting in vivo experiments using a hyperlipidemic rat model, our findings revealed that the hybrid microneedle-mediated administration exhibited superior therapeutic efficacy when compared to oral delivery methods. In summary, we have successfully developed a hybrid microneedle (MN) patch system that holds promising potential for the efficient transdermal delivery of hydrophobic drugs.

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The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

Cited by 16 publications

References 91 publications

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Ultra‐high‐performance liquid chromatography with tandem mass spectrometry method for cellular toxicity and pharmacokinetic study of PEG1K polymers

Hybrid Microneedle-Mediated Transdermal Delivery of Atorvastatin Calcium-Loaded Polymeric Micelles for Hyperlipidemia Therapy

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