Ultra‐high‐performance liquid chromatography with tandem mass spectrometry method for cellular toxicity and pharmacokinetic study of PEG1K polymers
Yuncheng Ge,
Ning Zhang,
Xinyue Zheng
et al.
Abstract:Polyethylene glycol (PEG) is one of the most commonly used polymers in drug delivery systems. The investigation of the pharmacokinetic behavior of PEG is important for revealing the toxicity and efficiency of PEG‐related Nano‐drug delivery systems. A high through‐put and selective ultra‐high‐performance liquid chromatography with tandem mass spectrometry (UHPLC‐MS/MS) method coupled with collision‐induced dissociation (CID) in source technique was developed and validated to determine PEG1K polymers in cellular… Show more
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