Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

Tang, Huan; Xie, Yizhuo; Zhu, Ming; Jia, Juan; Li, Rui; Shen, Yujia; Zheng, Yucui; Guo, Xin; Miao, Dongfanghui; Pei, Jin

doi:10.2147/ijn.s362263

Cited by 13 publications

(5 citation statements)

References 77 publications

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“…The relative bioavailability of the formulation was reflected by the area under the curve (AUC 0–t ). 53 The AUC 0–t values of Rg3, Rg1, and Rb1 in the Lip-Rg3/PNS group were 37.142, 74.556, and 25.162, respectively, in the MM-Lip-Rg3/PNS group, these values were 43.142 82.274, and 32.672, which were higher than the values in the Rg3/PNS group (8.720, 39.427, and 16.976). This proves that Lip-Rg3/PNS and MM-Lip-Rg3/PNS significantly improve bioavailability, suggesting a sustained release effect and extended drug presence in the plasma.…”

Section: Resultsmentioning

confidence: 99%

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Targeted Delivery of Macrophage Membrane Biomimetic Liposomes Through Intranasal Administration for Treatment of Ischemic Stroke

Liu,

Zhang,

Zhang

et al. 2024

IJN

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Section: Resultsmentioning

confidence: 99%

“…The relative bioavailability of the formulation was reflected by the area under the curve (AUC 0-t ). 53 The AUC 0-t values of Rg3, Rg1, and Rb1 in the Lip-Rg3/PNS group were 37.142, 74.556, and 25.162,…”

Section: Pharmacokinetics and Brain-targeting Evaluationmentioning

confidence: 92%

Targeted Delivery of Macrophage Membrane Biomimetic Liposomes Through Intranasal Administration for Treatment of Ischemic Stroke

Liu,

Zhang,

Zhang

et al. 2024

IJN

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“…Lip-Rg3/PNS was prepared using a thin-film dispersion method [ 73 ]. Firstly, egg yolk lecithin (EPC), Rg3, and cholesterol (Chol) were dissolved in a chloroform–methanol (2:3) solution and then spin-dried at 37 °C to form a thin film.…”

Section: Methodsmentioning

confidence: 99%

The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery

Liu,

Wang,

Zhang

et al. 2024

IJMS

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Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are currently lacking. In this study, we aimed to develop a novel nano delivery system to treat ischemic stroke via intranasal administration. A three-factor Box–Behnken experimental design was used to optimize the formulation of liposomes co-loaded with Panax notoginseng saponins (PNSs) and Ginsenoside Rg3 (Rg3) (Lip-Rg3/PNS). Macrophage membranes were coated onto the surface of the optimized liposomes to target the ischemic site of the brain. The double-loaded liposomes disguised by macrophage membranes (MM-Lip-Rg3/PNS) were spherical, in a “shell–core” structure, with encapsulation rates of 81.41% (PNS) and 93.81% (Rg3), and showed good stability. In vitro, MM-Lip-Rg3/PNS was taken up by brain endothelial cells via the clathrin-dependent endocytosis and micropinocytosis pathways. Network pharmacology experiments predicted that MM-Lip-Rg3/PNS could regulate multiple signaling pathways and treat ischemic stroke by reducing apoptosis and inflammatory responses. After 14 days of treatment with MM-Lip-Rg3/PNS, the survival rate, weight, and neurological score of middle cerebral artery occlusion (MCAO) rats significantly improved. The hematoxylin and eosin (H&E) and TUNEL staining results showed that MM-Lip-Rg3/PNS can reduce neuronal apoptosis and inflammatory cell infiltration and protect the ischemic brain. In vivo biological experiments have shown that free Rg3, PNS, and MM-Lip-Rg3/PNS can alleviate inflammation and apoptosis, especially MM-Lip-Rg3/PNS, indicating that biomimetic liposomes can improve the therapeutic effects of drugs. Overall, MM-Lip-Rg3/PNS is a potential biomimetic nano targeted formulation for ischemic stroke therapy.

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“…Liu et al developed a charge-reversed yolk shell liposome co-loaded with JQ1 and DOX, which improved hydrophobic drug loading capacity and stability under physiological conditions . Tang et al investigated the efficacy of estrogen-conjugated polyethylene glycol (PEG) liposome co-loaded with paclitaxel and carboplatin in ovarian cancer treatment, reducing acute toxicity of chemo-drugs . Krivosheeva et al studied the effects of substituents in Ce6 derivatives on the loading efficiency and bioactivity of photosensitizers into liposome membranes .…”

Section: Introductionmentioning

confidence: 99%

“… 14 Tang et al investigated the efficacy of estrogen-conjugated polyethylene glycol (PEG) liposome co-loaded with paclitaxel and carboplatin in ovarian cancer treatment, reducing acute toxicity of chemo-drugs. 15 Krivosheeva et al studied the effects of substituents in Ce6 derivatives on the loading efficiency and bioactivity of photosensitizers into liposome membranes. 16 However, the mechanical instability and leakiness of liposomes limited their potential applications in nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

Shen,

Zhang,

Wang

et al. 2023

ACS Omega

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Liposomes are considered the best nanocarrier for delivering cancer drugs such as chlorin e6 (Ce6) and paclitaxel (PTX). However, the poor stability and non-selectivity release of liposomes may severely limit their further applications. In this study, based on the characteristics of lutein (L) photo-response and orthoester (OE) acid-response, stable and dual-responsive liposomes (Dr-lips) have been prepared. The Dr-lips exhibited a spherical shape with a uniform size of approximately 58.27 nm. Moreover, they displayed a zeta potential ranging from −45.45 to −28.25 mV and showed excellent storage stability, indicating stable colloidal properties. Additionally, they achieved high drug encapsulation rates, with 92.27% for PTX and 90.34% for Ce6, respectively. Meanwhile, under near-infrared (NIR) light at 660 nm, Ce6 plays a key role in accelerating the photodegradation rate of lutein and PEG-OE-L while also enhancing tissue penetration ability. Additionally, Dr-lips loaded with Ce6 and PTX not only displayed excellent pH and photo dual-responsiveness for targeted delivering and releasing but also showed remarkable reactive oxygen species (ROS) generation capacity and impressive anti-tumor activity in vitro. Therefore, it provides a novel strategy for optimizing stability and enhancing their targeted drug delivery of liposome.

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Estrone-Conjugated PEGylated Liposome Co-Loaded Paclitaxel and Carboplatin Improve Anti-Tumor Efficacy in Ovarian Cancer and Reduce Acute Toxicity of Chemo-Drugs

Cited by 13 publications

References 77 publications

Targeted Delivery of Macrophage Membrane Biomimetic Liposomes Through Intranasal Administration for Treatment of Ischemic Stroke

Targeted Delivery of Macrophage Membrane Biomimetic Liposomes Through Intranasal Administration for Treatment of Ischemic Stroke

The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery

Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

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