Double emulsions with ultrathin shell by microfluidic step-emulsification

Ge, Xinjin; Rubinstein, Boris; He, Yifeng; Bruce, Frederick Nii Ofie; Li, Liaonan; Leshansky, Alexander; Li, Zhenzhen

doi:10.1039/d0lc01044h

Cited by 17 publications

(15 citation statements)

References 48 publications

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“…The thread pinching requires a sudden expansion of the channel width or height with a large enough expansion ratio, as shown by the numerical study on a biphasic flow in a H-S channel with constant height, a channel width expansion ratio equal to three induces significant thinning of the thread near the step, however, is not large enough to cause pinching [ 96 ]. The cf-SE can also be applied to tri-phasic flows to form double emulsions with controllable shell thickness [ 97 ]. The main advantage of the cf-SE method consists in the throughput per single channel.…”

Section: Methods Of Submicron Droplets Generationmentioning

confidence: 99%

Microfluidic Methods for Generation of Submicron Droplets: A Review

Huang

Xie

2023

Micromachines

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Submicron droplets are ubiquitous in nature and widely applied in fields such as biomedical diagnosis and therapy, oil recovery and energy conversion, among others. The submicron droplets are kinetically stable, their submicron size endows them with good mobility in highly constricted pathways, and the high surface-to-volume ratio allows effective loading of chemical components at the interface and good heat transfer performance. Conventional generation technology of submicron droplets in bulk involves high energy input, or relies on chemical energy released from the system. Microfluidic methods are widely used to generate highly monodispersed micron-sized or bigger droplets, while downsizing to the order of 100 nm was thought to be challenging because of sophisticated nanofabrication. In this review, we summarize the microfluidic methods that are promising for the generation of submicron droplets, with an emphasize on the device fabrication, operational condition, and resultant droplet size. Microfluidics offer a relatively energy-efficient and versatile tool for the generation of highly monodisperse submicron droplets.

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Section: Methods Of Submicron Droplets Generationmentioning

confidence: 99%

Microfluidic Methods for Generation of Submicron Droplets: A Review

Huang

Xie

2023

Micromachines

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“…For example, O/O/W double-emulsion drops are produced through single-step emulsification using PDMS microfluidic devices whose entire channel surfaces are hydrophilic. 22 The device is composed of a series of two cross-junctions followed by a step junction. In the series of cross junctions, a stable jet of oil core and oil sheath in continuous water is formed in the hydrophilic channel, which is emulsified to produce double-emulsion drops in a step junction.…”

Section: Microfluidic Productionmentioning

confidence: 99%

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

et al. 2022

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“…The generation of DEDs in a two-step emulsification process in microfluidic chips or capillary devices is a standard procedure [39][40][41]. However, many works focus on the fabrication of w 1 /o/w 2 DEDs with thin or even ultrathin shells due to increased stabilities of the droplets, and relatively high surfactant concentrations (often between 1-10 wt%) are utilized [28,33,[42][43][44][45][46]. While high detergent concentrations facilitate the production of double droplets, they must be avoided for droplet-ESI-MS coupling as they cause signal suppression and contamination of the MS [47].…”

Section: Development Of a Chip-capillary Setup To Generate Double-emu...mentioning

confidence: 99%

Analysis of double-emulsion droplets with ESI mass spectrometry for monitoring lipase-catalyzed ester hydrolysis at nanoliter scale

et al. 2022

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Microfluidic double-emulsion droplets allow the realization and study of biphasic chemical processes such as chemical reactions or extractions on the nanoliter scale. Double emulsions of the rare type (o1/w/o2) are used here to realize a lipase-catalyzed reaction in the non-polar phase. The surrounding aqueous phase induces the transfer of the hydrophilic product from the core oil phase, allowing on-the-fly MS analysis in single double droplets. A microfluidic two-step emulsification process is developed to generate the (o1/w/o2) double-emulsion droplets. In this first example of microfluidic double-emulsion MS coupling, we show in proof-of-concept experiments that the chemical composition of the water layer can be read online using ESI–MS. Double-emulsion droplets were further employed as two-phase micro-reactors for the hydrolysis of the lipophilic ester p-nitrophenyl palmitate catalyzed by the Candida antarctica lipase B (CalB). Finally, the formation of the hydrophilic reaction product p-nitrophenol within the double-emulsion droplet micro-reactors is verified by subjecting the double-emulsion droplets to online ESI–MS analysis. Graphical abstract

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Double emulsions with ultrathin shell by microfluidic step-emulsification

Abstract: Double emulsions with ultrathin shells are important in some biomedical applications, such as controlled drug release. However, the existing production techniques require two or more manipulation steps, or more complicated...

Cited by 17 publications

References 48 publications

Microfluidic Methods for Generation of Submicron Droplets: A Review

Microfluidic Methods for Generation of Submicron Droplets: A Review

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

Analysis of double-emulsion droplets with ESI mass spectrometry for monitoring lipase-catalyzed ester hydrolysis at nanoliter scale

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