“…Various functional microcapsules have been developed by different technological applications, such as microfluidics, spray drying, and interfacial polymerization ( Chen et al, 2019 ). Among them, microfluidics is a well-known strategy for rapidly preparing microcapsules with the desired morphology ( Kim et al, 2022 ). The obtained microcapsules can effectively encapsulate the cells, but the cell viability in them is usually not adequate because the hydrogel shell reduces cell viability and intercellular communication and the compact shell restricts the internal cells from accessing external nutrients and limits insulin exiting the enclosure ( Khanmohammadi et al, 2020 ; Liu et al, 2021 ; Kim et al, 2022 ).…”