Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues

Marine Based Natural Products: Exploring the Recent Developments in the Identification of Antimicrobial Agents

“…The synthetic analogs were screened for bactericidal activity and found that the compound 170 (Scheme 3) showed activity against Staphylococcus aureus with an IC 50 value of 3.8 μM (MIC = 25 μM). [66] Dinarvand and Spain reported the bioassay guided fractionation of marine extracts from sponges Lendenfeldia, Ircinia and Dysidea that led to the identification of novel compounds with antimicrobial properties. Potential structures of the bioactive fractions were assigned by using tandem mass spectrometry (MS) analysis.…”

Synthesis and antibacterial activity studies in vitro of indirubin-3′-monoximes

“…[1][2][3] have become an issue of great concern worldwide which seriously threatens global public health safety. [1][2][3][4][5][6][7][8][9][10][11][12] According to statistics, there is an annual death toll worldwide of 700 000 caused by antimicrobial resistance, and this value is expected to increase to up to 10 million in 2050. [4][5][6][7] As a consequence, there is an urgent and growing need for the development of novel antibacterial drugs to overcome bacterial resistance.…”

“…1,8 So the development and identification of new compounds with the antibacterial activity that serve as good candidates for developing novel antibacterial drugs are very urgent and important. 1,8…”

“…1 For pharmaceutical companies, most of them are not interested in the research and development program of new antibiotics due to their high costs and low prots. 1,8 So the development and identication of new compounds with the antibacterial activity that serve as good candidates for developing novel antibacterial drugs are very urgent and important. 1,8 Chinese medicine and pharmacology have a 5000 year-old tradition in China.…”

“…1,8 So the development and identication of new compounds with the antibacterial activity that serve as good candidates for developing novel antibacterial drugs are very urgent and important. 1,8 Chinese medicine and pharmacology have a 5000 year-old tradition in China. 13,19 Bioactive plant constituents, especially from medicinal plants used in traditional Chinese medicine (TCM), are also playing an increasingly important role in the process of current drug discovery and innovation.…”