Synthesis and antibacterial activity studies <i>in vitro</i> of indirubin-3′-monoximes

Yang, Fen-Fen; Shuai, Ming-Shan; Gao, Xiang; Zhang, Mao; Zhang, Qingqing; Fu, Xiao‐Zhong; Li, Zong-Qin; Wang, Dapeng; Yang, Yuanyong; Liu, Ting; He, Bin; Zhao, Yong-Long

doi:10.1039/d2ra01035f

Cited by 4 publications

(1 citation statement)

References 65 publications

(147 reference statements)

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“…Indirubin, a dark-red 3,2′-bisindole isomer of indigo, is also recognized as an active ingredient in Danggui Longhui Wan, a Traditional Chinese Medicine (TCM) employed in the treatment of chronic diseases like chronic myelogenous leukemia. 6–10 In addition to cyclin-dependent kinases (CDKs), indirubins have been observed to interact with glycogen synthase kinase-3 (GSK-3), aurora kinases, and the aryl hydrocarbon receptor (AhR), also known as the dioxin receptor. 2,3,11–13 Over the past decade, several indirubin analogs have been synthesized to enhance this promising drug scaffold.…”

Section: Introductionmentioning

confidence: 99%

The role of the oxime group in the excited state deactivation processes of indirubin

Nobre,

Delgado-Pinar,

Cunha

et al. 2024

Phys. Chem. Chem. Phys.

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Section: Introductionmentioning

confidence: 99%

The role of the oxime group in the excited state deactivation processes of indirubin

Nobre,

Delgado-Pinar,

Cunha

et al. 2024

Phys. Chem. Chem. Phys.

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Biocatalytic synthesis of asymmetric water-soluble indirubin derivatives

Sadauskas,

Jakutis,

Petkevičius

et al. 2023

Dyes and Pigments

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The molecules of colour. New structural derivatives from indigo: tryptanthrin and indirubin

Cunha,

Sérgio Seixas de Melo

2023

Photochemistry

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Two compounds, which are structurally related to indigo, tryptanthrin and indirubin, are here described in the context of recent findings in this new chapter of the Molecules of Colour. The two are naturally occurring compounds, with diversified applications. Indirubin, the red isomer of the blue indigo, shows, in comparison with indigo, a more efficient radiationless decay process, whose mechanism has been recently detailed and constitutes a step forward in the complexity of indigo’s deactivation and associated photostability. In contrast with indigo, tryptanthrin, which can be synthetically obtained from the former, has decay processes with efficient triplet state formation and singlet oxygen sensitization. Tryptanthrin, with its synthetically modified water-soluble compound, sulfonated-tryptanthrin, has also been shown to be electrochemically stable and a viable active organic material for eco-friendly all-organic redox flow batteries (AORFB). This new application of tryptanthrin, in an emerging source of energy power storage (RFB), is also discussed here.

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Synthesis and antibacterial activity studies in vitro of indirubin-3′-monoximes

Abstract: In this work, based on the unique scaffold of indirubin, we synthesized 29 indirubin-3′-monoximes and preliminarily evaluated their antibacterial activities, especially against S. aureus.

Cited by 4 publications

References 65 publications

The role of the oxime group in the excited state deactivation processes of indirubin

The role of the oxime group in the excited state deactivation processes of indirubin

Biocatalytic synthesis of asymmetric water-soluble indirubin derivatives

The molecules of colour. New structural derivatives from indigo: tryptanthrin and indirubin

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