The impact of Opisthorchis felineus infection and praziquantel treatment on the intestinal microbiota in children

Sokolova, Tatiana S.; Петров, В. А.; Saltykova, Irina V.; Dorofeeva, Yulia B.; Tyakht, Alexander; Огородова, Л. М.; Федорова, О. С.

doi:10.1016/j.actatropica.2021.105835

Cited by 5 publications

(4 citation statements)

References 78 publications

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“…In addition, among the other genera identified in this study with relative abundance at zero order of magnitude, Eubacterium exhibited the largest increasing trend (3.21%↑, p = 0.081) following anthelmintic treatment. The increase of Eubacterium after deworming was consistent with a study conducted in humans infected by Opisthorchis felineus ( 66 ). Eubacterium was found related with the physiology of horses, negatively correlated with salivary cortisol levels, but positively correlated with N-butyrate production ( 67 ).…”

Section: Resultssupporting

confidence: 91%

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

Yang²,

et al. 2021

Front. Vet. Sci.

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Intestinal microbiota is involved in immune response and metabolism of the host. The frequent use of anthelmintic compounds for parasite expulsion causes disturbance to the equine intestinal microbiota. However, most studies were on the effects of such treatment on the intestinal bacterial microbes; none is on the entire microbial community including archaea and eukaryotic and viral community in equine animals. This study is the first to explore the differences of the microbial community composition and structure in Przewalski's horses prior to and following anthelmintic treatment, and to determine the corresponding changes of their functional attributes based on metagenomic sequencing. Results showed that in archaea, the methanogen of Euryarchaeota was the dominant phylum. Under this phylum, anthelmintic treatment increased the Methanobrevibacter genus and decreased the Methanocorpusculum genus and two other dominant archaea species, Methanocorpusculum labreanum and Methanocorpusculum bavaricum. In bacteria, Firmicutes and Bacteroidetes were the dominant phyla. Anthelmintic treatment increased the genera of Clostridium and Eubacterium and decreased those of Bacteroides and Prevotella and dominant bacteria species. These altered genera were associated with immunity and digestion. In eukaryota, anthelmintic treatment also changed the genera related to digestion and substantially decreased the relative abundances of identified species. In virus, anthelmintic treatment increased the genus of unclassified_d__Viruses and decreased those of unclassified_f__Siphoviridae and unclassified_f__Myoviridae. Most of the identified viral species were classified into phage, which were more sensitive to anthelmintic treatment than other viruses. Furthermore, anthelmintic treatment was found to increase the number of pathogens related to some clinical diseases in horses. The COG and KEGG function analysis showed that the intestinal microbiota of Przewalski's horse mainly participated in the carbohydrate and amino acid metabolism. The anthelmintic treatment did not change their overall function; however, it displaced the population of the functional microbes involved in each function or pathway. These results provide a complete view on the changes caused by anthelmintic treatment in the intestinal microbiota of the Przewalski's horses.

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Section: Resultssupporting

confidence: 91%

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

Yang²,

et al. 2021

Front. Vet. Sci.

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“…Previous studies have demonstrated that intestinal worm infections increase the abundance of the Eu . eligens group in the intestine ( Sokolova et al., 2021 ). In addition, Eu .…”

Section: Discussionmentioning

confidence: 99%

Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection

Gong

et al. 2022

Front. Cell. Infect. Microbiol.

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Pentatrichomonas hominis is a parasitic trichomonads protozoa that parasitizes in the colon and cecum of humans and other animals. Our previous studies have demonstrated that infection with P. hominis is associated with the incidence of colon cancer (37.93%). However, the mechanism by which P. hominis infections increase the incidence of colon cancer remains unclear. Previous studies have suggested that certain parasites promote colon cancer by regulating gut microbiota. This study aimed to elucidate whether the association between P. hominis infections and the increased incidence of colon cancer is related to changes in gut microbiota. Therefore, the gut microbiota patients with colon cancer who were infected with P. hominis and uninfected patients with colon cancer were analyzed by 16S rRNA high-throughput sequencing. The results demonstrated that patients with colon cancer who were not infected with P. hominis showed increased gut bacterial diversity, a higher relative abundance of Alcaligenes sp., Leucobacter sp., Paraprevotella sp., Ruminococcaceae UCG-002, and a significant reduction in the abundance of Veillonella sp., compared to individuals without colon cancer. Additionally, the relative abundance of the Ruminococcaceae UCG-002 and the Eubacterium eligens groups was reduced, while the relative abundance of bacteria associated with colon cancer, including Flavonifractor sp., Lachnoclostridium sp., and the Ruminococcus gnavus group, increased significantly in patients with colon cancer who were infected with P. hominis, compared to those of uninfected patients with colon cancer. In conclusion, these results suggested that P. hominis infections may aggravate the development of colon cancer and the findings provide new insights for subsequent in-depth studies on the pathogenesis, diagnosis, and prevention of colon cancer.

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“…Studies in both animal models and human trials have demonstrated that anthelminthic treatment does not always automatically restore the GM to a pre‐infection state. In some cases, the GM is largely unaffected by antiparasitic drugs 38,39,83 . In others, the GM responds to anthelminthic treatment, not by returning to a pre‐infection state, but rather by reaching an entirely different microbial balance, at times with the expansion of bacterial taxa that are associated with intestinal inflammation, and at other times with those that are considered ‘anti‐inflammatory’ 32,35,36,41,214,215 .…”

Section: Discussionmentioning

confidence: 99%

Impact of helminth–microbiome interactions on childhood health and development—A clinical perspective

Piazzesi

Putignani

2022

Parasite Immunology

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Humans have co-existed with parasites for virtually the entirety of our existence as a species. Today, nearly one third of the human population is infected with at least one helminthic species, most of which reside in the intestinal tract, where they have coevolved alongside the human gut microbiota (GM). Appreciation for the interconnected relationship between helminths and GM has increased in recent years. Here, we review the evidence of how helminths and GM can influence various aspects of childhood development and the onset of paediatric diseases. We discuss the emerging evidence of how many of the changes that parasitic worms inflict on their host is enacted through gut microbes. In this light, we argue that helminth-induced microbiota modifications are of great importance in both facing the global challenge of overcoming parasitic infections, and in replicating helminthic protective effects against inflammatory diseases. We propose that deepening our knowledge of helminth-microbiota interactions will uncover novel, safer and more effective therapeutic strategies in combatting an array of childhood disorders.

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The impact of Opisthorchis felineus infection and praziquantel treatment on the intestinal microbiota in children

Cited by 5 publications

References 78 publications

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection

Impact of helminth–microbiome interactions on childhood health and development—A clinical perspective

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