Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection

Abstract

Pentatrichomonas hominis is a parasitic trichomonads protozoa that parasitizes in the colon and cecum of humans and other animals. Our previous studies have demonstrated that infection with P. hominis is associated with the incidence of colon cancer (37.93%). However, the mechanism by which P. hominis infections increase the incidence of colon cancer remains unclear. Previous studies have suggested that certain parasites promote colon cancer by regulating gut microbiota. This study aimed to elucidate whether the association between P. hominis infections and the increased incidence of colon cancer is related to changes in gut microbiota. Therefore, the gut microbiota patients with colon cancer who were infected with P. hominis and uninfected patients with colon cancer were analyzed by 16S rRNA high-throughput sequencing. The results demonstrated that patients with colon cancer who were not infected with P. hominis showed increased gut bacterial diversity, a higher relative abundance of Alcaligenes sp., Leucobacter sp., Paraprevotella sp., Ruminococcaceae UCG-002, and a significant reduction in the abundance of Veillonella sp., compared to individuals without colon cancer. Additionally, the relative abundance of the Ruminococcaceae UCG-002 and the Eubacterium eligens groups was reduced, while the relative abundance of bacteria associated with colon cancer, including Flavonifractor sp., Lachnoclostridium sp., and the Ruminococcus gnavus group, increased significantly in patients with colon cancer who were infected with P. hominis, compared to those of uninfected patients with colon cancer. In conclusion, these results suggested that P. hominis infections may aggravate the development of colon cancer and the findings provide new insights for subsequent in-depth studies on the pathogenesis, diagnosis, and prevention of colon cancer.

Exopolysaccharides Produced by Bifidobacterium longum subsp. longum YS108R Ameliorates DSS-Induced Ulcerative Colitis in Mice by Improving the Gut Barrier and Regulating the Gut Microbiota

“…Ruminococcaceae UCG-010 has a significant positive correlation with Occludin, while Ruminococcaceae UCG-014 and Candidatus Saccharimonas show a negative correlation with pro-inflammatory cytokines, , among which Ruminococcaceae UCG-014 is also capable of degrading complex carbohydrates . Of note, Coriobacteriaceae UCG-002 , Butyricimonas , Parabacteroides , Ruminococcaceae UCG-010 , and Ruminococcaceae UCG-014 are known to produce SCFAs, primarily propionate and butyrate. ,− Moreover, the relative abundances of Enterococcus , Lachnospiraceae NK4A136 group , and Escherichia-Shigella were noticeably diminished by YS108R EPS treatment. Enterococcus , a well-studied pathogenic genus, impairs the intestinal epithelial barrier through disruption of TJ function, becoming a contributor to gut inflammation, and is heavily enriched in patients with intestinal diseases, such as CRC and CD .…”

Gut microbiome as a biomarker for predicting early recurrence of HBV‐related hepatocellular carcinoma

“…The Eubacterium coprostanoligenes group is an anaerobic Gram‐positive coccus that degrades cholesterol, with metabolites including acetic acid, formic acid, and succinic acid. Veillonella is a common Gram‐negative anaerobic micrococcus found in the mouth cavity and intestine, 21 which can utilize lactic acid to create propionate and acetic acid 22 . Wang et al found that Lactobacillus reuteri regulates type 3 innate lymphoid cells (ILC3s) in HCC through acetic acid 23 .…”

“…Veillonella is a common Gram-negative anaerobic micrococcus found in the mouth cavity and intestine, 21 which can utilize lactic acid to create propionate and acetic acid. 22 Wang et al found…”

Bufotalin-loaded biomimetic prussian blue nanoparticles for colorectal cancer chemo-photothermal therapy via induce ferroptosis

“…The changes in intestinal microbiota may be related to the curative effect of colon cancer therapy [51,52]. Therefore, 16S ribosomal RNA (rRNA) sequencing analysis was performed to investigate the change of intestinal microbiota after PCM plus Laser-induced treatment.…”