Isolation and neuroprotective prospective of novel bioactive compound “3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one” against ketamine-induced cognitive deficits in schizophrenia: an experimental study

Venkataramaiah, Chintha; Rajendra, Wudayagiri

doi:10.1080/14786419.2020.1869968

Cited by 3 publications

(3 citation statements)

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“…A new flavonoid compound, 3‐(3,4‐dimethoxyphenyl)‐1‐(4‐methoxyphenyl)prop‐2‐en‐1‐one isolated from methanolic extract of seeds showed significant neuroprotective effect against ketamine‐induced cognitive deficits in rats. Ketamine‐affected cholinergic variations in different parts of the brain were retained to normal levels after treating with this compound on par with clozapine (standard drug) (Chintha & Wudayagiri, 2021). Investigations conducted against methyl mercury caused nerve toxicity in the cerebellum of male Wister rats revealed an increased mitochondrial electron transport chain activity, lessened release of cytochrome C and higher rate caspase 3 mRNA expressions upon treatment of the subject with C. paniculatus seed ethanolic extract.…”

Section: Central Nervous System Activitiesmentioning

confidence: 99%

An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd

Nagpal

Garg

Arora

et al. 2022

Phytotherapy Research

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Celastrus paniculatus is a traditional herb belonging to the family Celastraceae and is widely used for a number of medicinal activities in the Indian Unani and Ayurvedic systems. In this study, the extensive literature search was carried out on phytochemistry, ethnobotanical uses and pharmacological activities of C. paniculatus (Willd.) in various scientific databases as well as patents. Research on phytochemical investigation has shown the presence of monoterpenes (linalool, α‐terpinyl acetate, nerol acetate), sesqueterpene esters (such as malkanguniol, malkangunin, valerenal, globulol, viridiflorol, cubenol and agarofuran derivatives), diterpenoids (such as phytone, isophytol), triterpenoids (such as lupeol, pristimerin, paniculatadiol, zeylasteral, zeylasterone, β‐amyrin, squalene), alkaloids (celapanin, celapanigin, celapagin, paniculatine, celastrine, maymyrsine), fatty acids, steroids (β‐sitosterol, carpesterol benzoate), flavonoids (paniculatin), benzoic acid, and vitamin C in this plant. All the reported pharmacological activities of this plant could be due to the presence of these phytochemicals. This plant possesses strong antioxidant activity which includes total flavonoid content, total phenolic content, nitric oxide scavenging activity and free radical scavenging activity. This plant possesses multiple pharmacological activities including cognition‐enhancing, neuroprotective, antipsychotic, anti‐depressant, antibacterial, anti‐arthritic, anti‐malarial, analgesic, anti‐inflammatory, anti‐fertility, cardiovascular, locomotor, anxiolytic, wound healing activity, anti‐spasmodic, hypolipidemic, anti‐cancerous and iron‐chelating activity with different extracts of this plant as well as various phytoconstituents present in this plant. The objective of this review article is to discuss in detail the reported ethnopharmacological uses, phytochemistry and various pharmacological activities of C. paniculatus.

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Section: Central Nervous System Activitiesmentioning

confidence: 99%

An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd

Nagpal

Garg

Arora

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

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“…The bioactive principle used in the current study for the determination of neuroprotective activity was previously isolated, characterized from the seeds of the medicinal plant Celastrus paniculatus and was reported for in vivo neuroprotective activity with particular reference to the cholinergic, dopaminergic, glutamatergic, and ATPase systems [15][16][17][18]. PC 12, a cell line derived from pheochromocytomas of the rat adrenal medulla, has an embryonic origin from the neural crest, has a mixture of neuroblastic properties, and has been reported in the study of expressions of catecholamines, dopamine, and norepinephrine.…”

Section: Source Of Plant Constituent and Cell Linesmentioning

confidence: 99%

“…Several research groups, such as Zhanget et al (2004), Bigoniya and Rana (2005), and Kothari et al (2010), identified and reported several medicinal plants exhibiting antipsychotic and antidepressant activities using in vivo models [12][13][14]. In view of the relative promising activity of the flavonoid group of molecules from medicinal plants as potent neuroprotective agents, in our previous study, we isolated and characterized a bioactive compound, 3-(3,4-dimethoxy phenyl)-1-(4-methoxy phenyl)prop-2-en-1-one (structural analog of flavonoid), from the medicinal plant Celastrus paniculatus (CP) and reported its neuroprotective activity in vivo, with particular reference to the cholinergic, dopaminergic, glutamatergic, and ATPase systems [15][16][17][18]. In continuation of the earlier studies, the current study aimed to determine the in vitro neuroprotective activity of this bioactive compound against ketamine-induced neurotoxicity in PC 12 cell lines.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Potentiality of Bioactive Flavonoid against Ketamine Induced Cell Death of PC 12 Cell Lines: An In Vitro Study

et al. 2021

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During the past few years, there has been exponential growth in the field of ethnopharmacology in the treatment of different human ailments, including neurological disorders. In our previous study, we isolated, characterized, and reported a novel bioactive compound with therapeutic efficacy in vivo, which was used in the current study. This study was designed to investigate the pharmacological effect and therapeutic mechanism of the natural plant compound 3-(3,4-dimethoxy phenyl)-1-(4-methoxy phenyl)prop-2-en-1-one against ketamine-induced toxicity in PC 12 cell lines. Cell death was induced in PC 12 cell lines by incubating with ketamine, and the protection offered by the compound at different concentrations was studied during pretreatment. The therapeutic efficacy was screened through MTT assay, LDH assay, DCF-DA assay, clonogenic assay, RT-PCR, and densitometric analysis. The bioactive compound caused a significant elevation in cell viability up to approximately 80%, down-regulation of cell damage, reduction in free radical damage caused by intracellular reactive oxygen species, and up-regulation of cell survival ability, which was dysregulated during ketamine induction. In addition, RT-PCR analysis of DOPA-related genes suggests that the compound exerted significant inhibition in the expression of these genes, which were overexpressed during ketamine induction. The current findings provide new insight into the neuroprotective mediation of bioactive factors as a prospective therapy for neurological disorders.

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Phytochemistry and pharmacology of Celastrus paniculatus Wild.: a nootropic drug

Aleem¹

2021

Journal of Complementary and Integrative Medicine

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Objectives Celastrus paniculatus Wild is an evergreen climbing shrub. The plant is of great significance in the traditional Indian System of Medicine, such as Ayurveda, Unani, and Siddha. The seeds and their oil are extensively used to treat neurological disorders such as cognitive dysfunction, paralysis, epilepsy, insomnia, and other ailments like rheumatism, arthritis, sciatica, and leprosy. This paper aims to highlight the nootropic activity of C. paniculatus and explore its phytochemistry, traditional uses, and other pharmacological activities. Methods All available information concerning C. paniculatus has been searched in the internationally accepted scientific databases, including PubMed, ScienceDirect, Scopus, and Google Scholar. Additional knowledge was gathered from the classical Textbooks and Unani Pharmacopoeia. Results C. paniculatus is a rich source of several secondary metabolites, such as β-Dihydroagarofuranoids sesquiterpenes, alkaloids (Celastrine, Celapanin, Celapagin, and paniculatin), flavonoids, terpenoid (β-amyrin, Lupeol, Pristimerin), sterols (β-sitosterol, campesterol, stigmasterol, α-tocopherol, γ-Tocopherol), fatty acid (palmitic, stearic, oleic, linoleic, linolenic acids) and non-fatty acids (Benzoic acid, Cinnamic acid). The various study shows that the extracts and active constituent of this plant possess potent nootropic activity. Besides nootropic activity, it has also been reported for anti-Alzheimer, anticonvulsant, antidepressant, antioxidant, analgesic, anti-inflammatory, antiarthritic, gastroprotective, anti-psoriatic, wound healing, antibacterial, antimalarial, and several other properties. Conclusions Several in vitro and in vivo trials confirm the conventional use of C. paniculatus in cognitive dysfunction. However, the relations between the possible mechanisms of other activities and traditional uses of the C. paniculatus remain indistinct. Still, pharmacological studies also explored the effects of C. paniculatus, which were not recognized in ancient times, such as cytotoxic, ACE inhibitor, and antidiabetic activities. These discoveries are may be beneficial in the development of the new drug to treat various diseases. It is also confirmed that the β-dihydroagarofuranoids exhibit significant AChE inhibitory, cytotoxic, antibacterial, and insecticidal effects. This versatile medicine is truly a life elixir. Considering the therapeutic importance of the C. paniculatus and the absence of any reported clinical studies, extensive clinical trials are needed to explore its memory enhancing and other activities.

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Isolation and neuroprotective prospective of novel bioactive compound “3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one” against ketamine-induced cognitive deficits in schizophrenia: an experimental study

Cited by 3 publications

References 14 publications

An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd

An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd

Pharmacological Potentiality of Bioactive Flavonoid against Ketamine Induced Cell Death of PC 12 Cell Lines: An In Vitro Study

Phytochemistry and pharmacology of Celastrus paniculatus Wild.: a nootropic drug

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