An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd

Abstract

Celastrus paniculatus is a traditional herb belonging to the family Celastraceae and is widely used for a number of medicinal activities in the Indian Unani and Ayurvedic systems. In this study, the extensive literature search was carried out on phytochemistry, ethnobotanical uses and pharmacological activities of C. paniculatus (Willd.) in various scientific databases as well as patents. Research on phytochemical investigation has shown the presence of monoterpenes (linalool, α‐terpinyl acetate, nerol acetate), sesqueterpene esters (such as malkanguniol, malkangunin, valerenal, globulol, viridiflorol, cubenol and agarofuran derivatives), diterpenoids (such as phytone, isophytol), triterpenoids (such as lupeol, pristimerin, paniculatadiol, zeylasteral, zeylasterone, β‐amyrin, squalene), alkaloids (celapanin, celapanigin, celapagin, paniculatine, celastrine, maymyrsine), fatty acids, steroids (β‐sitosterol, carpesterol benzoate), flavonoids (paniculatin), benzoic acid, and vitamin C in this plant. All the reported pharmacological activities of this plant could be due to the presence of these phytochemicals. This plant possesses strong antioxidant activity which includes total flavonoid content, total phenolic content, nitric oxide scavenging activity and free radical scavenging activity. This plant possesses multiple pharmacological activities including cognition‐enhancing, neuroprotective, antipsychotic, anti‐depressant, antibacterial, anti‐arthritic, anti‐malarial, analgesic, anti‐inflammatory, anti‐fertility, cardiovascular, locomotor, anxiolytic, wound healing activity, anti‐spasmodic, hypolipidemic, anti‐cancerous and iron‐chelating activity with different extracts of this plant as well as various phytoconstituents present in this plant. The objective of this review article is to discuss in detail the reported ethnopharmacological uses, phytochemistry and various pharmacological activities of C. paniculatus.

The effect of stir‐frying on the aging of oat flour during storage: A study based on lipidomics

“…The disruption of hydrogen bonding under high‐temperature stir‐frying conditions provides additional conformational degrees of freedom, allowing the glycosidic bond to be more readily protonated and the β‐glycosidic bond between the hydroxyl group at the 1‐position of the ceramide and the sugar moiety (D‐galactose or D‐glucose) to be cleaved with a much lower hurdle in turn (Paajanen et al., 2021 ). Plant sterol esters are generally synthesized from plant sterol and fatty acids by esterification or transesterification (Nagpal et al., 2022 ). As sitosterol ester (SiE) (20:5) and stigmasterol ester (StE) (19:2) were lower in C0, our findings indicated that stir‐frying treatment also destroyed sterol esters.…”

Neuropsychopharmacological Induction of (Lucid) Dreams: A Narrative Review

“…This plant has been used for more than a thousand years in Indian Ayurvedic medicine, commonly called "the intellect tree", from Hindu, Malkangani. Celastrus paniculatus has therapeutic potential, from oil and methanol extract to seeds [72,73]. Its neuroprotective potential has already been tested for schizophrenia induced by ketamine in rats, treating the disorder combined with clozapine or alone.…”

Antimicrobial Activity of Secondary Metabolites in Medicinal Plants: An Update

“…Estevez-Braun et al reported a polyacetylene C17 plant innate to the Canary islands, confined from Bupleurum salicifolium. 28 Aqueous extract of Celastrus paniculatus was found to be effective against bacterial and fungal strains owing to presence of phenolic components [29].…”