Longitudinal melanonychia and skin hyperpigmentation associated with hydroxychloroquine therapy

Ricardo, José; Chikeka, Ijeuru; Silvers, David N.; Lipner, Shari R.

doi:10.1016/j.jdcr.2020.10.030

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Hydroxychloroquine has been widely used in prevention and treatment of SARS‐CoV‐2 infection but sound evidence for a clinical benefit is lacking. Hydroxychloroquine‐induced longitudinal melanonychia is a possible adverse event 37 …”

Section: Nail Changes Induced By Sars‐cov‐2 Infectionmentioning

confidence: 99%

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Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Wollina

Kanitakis

Baran

2021

Dermatologic Therapy

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The SARS‐CoV‐2 infection, responsible for COVID‐19, has raised the interest for infection‐associated muco‐cutaneous symptoms. While dermatologic symptoms in general gained an increasing awareness, affection of the nail organ has been mentioned only recently. We provide a narrative review on COVID‐19 manifestation on the nail organ and add symptoms induced by personal protective measures and SARS‐CoV‐2 vaccination. Available treatment options are discussed.

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Section: Nail Changes Induced By Sars‐cov‐2 Infectionmentioning

confidence: 99%

“…Hydroxychloroquine-induced longitudinal melanonychia is a possible adverse event. 37 The most important differential diagnosis of drug-induced melanonychia is subungual melanoma, which warrants a nail biopsy. 38…”

Section: Nail Changes Induced By Covid-19 Treatmentsmentioning

confidence: 99%

Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Wollina

Kanitakis

Baran

2021

Dermatologic Therapy

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Drug-Induced Pigmentation: A Review

Tisack,

Mohammad

2024

Drugs

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Skin and ophthalmic complications of chloroquine and hydroxychloroquine in patients with rheumatoid arthritis and systemic lupus erythematous

Zamani,

Hasan‑Abad,

Rafizadeh

et al. 2024

Journal of Immunoassay and Immunochemistry

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Introduction: Immunosuppressive agents are routinely used to control autoimmunity. However, some adverse events are correlated to their clinical applications. The aim of this study was to study the clinical ndings and ocular and cutaneous side effects of chloroquine (CQ) and hydroxychloroquine (HCQ), as current immunosuppressive drugs, in patients with rheumatoid arthritis (RA) and systemic lupus erythematous (SLE).Materials and Methods: This descriptive study was performed on 360 individuals referred to the Rheumatology clinic during 2003-2020. Demographic characteristics and other information were collected from patients with RA and SLE. Skin and ocular complications were evaluated in patients who were on treatment with CQ and HCQ.Results: Study populations consisted of 199 subjects with RA and 161 cases with SLE. The frequencies of skin and ocular complications in all patients treated with CQ and HCQ were 42 (11.66%) and 97 (26.9%), respectively. The prevalence of skin complications in patients with RA and SLE was 20 (10.1%) and 22 (13.7%), respectively. The frequencies of ocular complications in patients with RA and SLE were, respectively, 60 (30.2%) and 37 (23%). The results showed that ocular complications in patients with RA were signi cantly associated with disease duration (p <0.05). Cutaneous and ocular complications in patients showed a signi cant difference with the cumulative dose of drug (p <0.05).Conclusion:Based on these ndings, treatment with CQ and HCQ participates in some skin and ocular complications in patients with RA and SLE which are largely associated with the duration of disease and treatment.

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Longitudinal melanonychia and skin hyperpigmentation associated with hydroxychloroquine therapy

Cited by 5 publications

References 7 publications

Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Nails and COVID ‐19 – A comprehensive review of clinical findings and treatment

Drug-Induced Pigmentation: A Review

Skin and ophthalmic complications of chloroquine and hydroxychloroquine in patients with rheumatoid arthritis and systemic lupus erythematous

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