A two-dimensional photonic crystal hydrogel biosensor for colorimetric detection of penicillin G and penicillinase inhibitors

Wang, Changping; Xiao, Fubing; Chen, Qianshan; Wang, Shihong; Zhou, Jun; Wu, Zhaoyang

doi:10.1039/d0an01946a

Cited by 20 publications

(15 citation statements)

References 43 publications

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“…Several RBPCHs with enzymes as receptors have been reported. A study with penicillin as the tested target [63] directly introduced penicillinases as acceptors in AAm&AAc hydrogels. Penicillinases then hydrolyzed penicillin G to produce penicilloic acid.…”

Section: Photonic Crystals Hydrogels Combined With Biomacromolecule R...mentioning

confidence: 99%

Application of optical hydrogels in environmental sensing

Yang

Sarkar

Xie

et al. 2023

Preprint

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The ever-increasing complexity of environmental pollutants urgently warrants the development of new detection technologies. In this context, sensors based on the optical properties of hydrogels enabling fast and easy in situ detection are attracting increasing attention. Herein, the target recognition and sensing mechanisms of two main types of optical hydrogels (OHs) are reviewed and discussed: photonic crystal hydrogels (PCHs) and fluorescent hydrogels (FHs). For PCHs, the environmental stimulus response, target receptors, inverse opal structures, and molecular imprinting techniques related to PCHs are reviewed and summarized. Furthermore, the different types of fluorophores (i.e., compound probes, biomacromolecules, quantum dots, and luminescent microbes) of FHs are summarized. Finally, the data from 138 papers about different OHs are extracted for secondary statistical analysis. The detection performance and potential of various OH types in different environmental pollutant detection scenarios are evaluated, and compared them to those obtained using the standard detection method. Based on this analysis, some possible development directions are proposed, including the fusion of various OHs, introduction of more hydrogel technologies from the biomedical field to the environmental pollutant detection field, and development of multifunctional sensor arrays.

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Section: Photonic Crystals Hydrogels Combined With Biomacromolecule R...mentioning

confidence: 99%

Application of optical hydrogels in environmental sensing

Yang

Sarkar

Xie

et al. 2023

Preprint

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“…[31] A facile colorimetric method to detect residual PENÀ G in milk using amineimmobilized glass vials and dendritic platinum nanoparticles has been developed by Kwon et al. [32] A simple penicillinase functionalized two-dimensional photonic crystal hydrogel (2DPPCH) biosensor was developed for colorimetric detection of PEN-G. [33] Aghamirzaei et al detected beta-lactam antibiotics penicillin using a conjugated antibody with gold nanoparticles. For this purpose, the gold nanoparticles synthesized from Chinese lettuce leaf extract (as reductant) were used for the colorimetric detection of penicillin.…”

Section: The Determination Of Pen-g From Milk Samplementioning

confidence: 99%

“…[11][12][13] Sensors are analytical devices that have a combination of simple and convenient converter receptors containing biological recognition elements. [14] In the last years, electrochemical [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and optical sensors based on fluorometric and colorimetric measurements [30][31][32][33] have been used for the estimation of penicillin antibiotics due to their high reactivity and selectivity. Surface plasmon resonance (SPR) is an optical technique based on the intensity of reflected light in a prism covered with a thin metal film.…”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Polymer‐Based Optical Sensor for the Sensitive Penicillin G Detection in Milk

et al. 2021

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In this study, selective and sensitive Penicillin G (PEN−G) antibiotic detection from both aqueous solution and milk samples using molecular imprinting technique was performed by surface plasmon resonance sensor. For this purpose, PEN−G imprinted poly(2‐Hydroxyethyl methacrylate‐N‐methacroyl‐(L)‐cysteine methyl ester‐gold nanoparticles‐N‐methacryloyl‐L‐phenylalanine methyl ester (MIP‐AuNPs) nanosensor was prepared. Control experiments were carried out via the nanosensor without the addition of AuNPs (MIP) to examine the effect of gold nanoparticles (AuNPs) incorporated to increase the surface plasmon resonance signal response. Moreover, to evaluate the imprinting efficiency, non‐imprinted (NIP‐AuNPs) nanosensor was designed using the same polymerization recipe except the addition of the PEN−G molecule. Characterization studies of MIP, MIP‐AuNPs and NIP‐AuNPs nanosensors were performed with FTIR‐ATR spectrophotometer. Also, MIP‐AuNPs and NIP‐AuNPs nanosensors were characterized by atomic force microscopy, ellipsometer and contact angle measurements. Imprinting efficiency (I.F: 7.83) for the MIP‐AuNPs nanosensor was determined by comparing it with the NIP‐AuNPs nanosensor. The MIP‐AuNPs nanosensor was 9.87 times more selective for the target PEN−G molecule than amoxicillin, and 16.78‐times than ampicillin. In addition, the amount of PEN−G in milk selected as a real sample was measured by spiking 5 ppb PEN−G into the milk.

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“…Photonic crystals (PCs) are a class of novel optical materials with periodic micro-/nano-structures that possess a photonic bandgap to control and manipulate the flow of light in the visible region and thus exhibit bright structural colors. [14][15][16][17] Fixing colloidal PCs, such as monodisperse polystyrene (PS), [18][19][20][21] silica (SiO 2 ), 22,23 and superparamagnetic colloidal nanoparticles, [24][25][26] in responsive polymers brings about responsive photonic hydrogels (RPHs), which have the capability of adjusting the lattice spacing among the embedded PC particles in response to the volume change of hydrogels (swelling or shrinkage) caused by various external stimuli (temperature, humidity, pressure, pH, ions, molecules, and bacteria), [27][28][29][30][31][32][33][34] thus generating various brilliant colors. Such RPHs with embedded PCs do not suffer from photobleaching, and their striking advantage of having colourfast, highly stable, bright colors enable them to be ideal colorimetric detection devices compared with other sensing platforms.…”

Section: Introductionmentioning

confidence: 99%

A novel ion-responsive photonic hydrogel sensor for portable visual detection and timely removal of lead ions in water

Peng

Wen

et al. 2022

Mater. Adv.

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A two-dimensional photonic crystal hydrogel biosensor for colorimetric detection of penicillin G and penicillinase inhibitors

Abstract: A simple penicillinase functionalized two-dimensional photonic crystal hydrogel (2DPPCH) biosensor was developed for colorimetric detection of penicillin G and penicillinase inhibitor. The penicillinase can specifically recognize penicillin G and catalyze...

Cited by 20 publications

References 43 publications

Application of optical hydrogels in environmental sensing

Application of optical hydrogels in environmental sensing

Development of Molecularly Imprinted Polymer‐Based Optical Sensor for the Sensitive Penicillin G Detection in Milk

A novel ion-responsive photonic hydrogel sensor for portable visual detection and timely removal of lead ions in water

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