The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Bakadia, Bianza Moïse; Boni, B; Ahmed, Abeer Ahmed Qaed; Yang, Guang

doi:10.1016/j.lfs.2020.118653

Cited by 44 publications

(40 citation statements)

References 100 publications

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“…SARS-CoV-2 transmission is mainly mediated by saliva droplets [ 16 ]. The FDA has approved saliva as a source of virus detection.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that chronic stress can stimulate the conserved transcriptional response to adversit through the sympathetic nervous system, leading to the induction of proinflammatory cytokines and the suppression of genes involved in the production of antibodies and interferons, causing vulnerability to viral infections. Proinflammatory cytokines induce chronic inflammation and generate ROS, thus producing an unbalanced oxidative stress response [ 58 ]. Oxidative stress results from an imbalance in the generation of oxidizing compounds and the performance of antioxidant defense systems [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…Protocols with behavioral tests, as well as the evaluation of laboratory parameters capable of assisting in such investigations, are also important tools for understanding the results of such studies worldwide [ 12 ]. Biochemical, hematological, coagulatory, and oxidative damage markers stand out among the investigated laboratory parameters, in addition to numerous inflammatory markers, particularly cytokines, which can be detected in cases of SARS-CoV-2 infection [ [15] , [16] , [17] ]. We believe that the study of these markers combined with the detection of SARS-CoV-2 by a fast and less expensive technique could be an interesting tool to assist professionals to assess their condition.…”

Section: Introductionmentioning

confidence: 99%

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Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Trassante¹,

Barboza²,

Rocha³

et al. 2021

Microbial Pathogenesis

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In early December 2019, an outbreak of coronavirus disease 2019 caused by a new strain of coronavirus (SARS-CoV-2), occurred in the city of Wuhan, Hubei Province, China. On January 30, 2020, the World Health Organization (WHO) declared the outbreak a public health emergency of international concern. Since then, frontline healthcare professionals have been experiencing extremely stressful situations and damage to their physical and mental health. These adverse conditions cause stress and biochemical, hematological, and inflammatory changes, as well as oxidative damage, and could be potentially detrimental to the health of the individual. The study population consisted of frontline health professionals working in BHU in a city in southern Brazil. Among the 45 participants, two were infected with the SARS-CoV-2 virus and were diagnosed using immunochromatographic tests such as salivary RT-LAMP and qRT-PCR. We also evaluated biochemical, hematological, inflammatory, and oxidative stress markers in the participants. The infected professionals (CoV-2-Prof) showed a significant increase in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, lactic dehydrogenase, lymphocytes, and monocytes. In this group, the levels of uric acid, triglycerides, leukocytes, neutrophils, hemoglobin, hematocrit, and platelets decreased. In the group of uninfected professionals (NoCoV-2-Prof), significant increase in HDL levels and the percentages of eosinophils and monocytes, was observed. Further, in this group, uric acid, LDH, triglyceride, and cholesterol levels, and the hematocrit count and mean corpuscular volume were significantly reduced. Both groups showed significant inflammatory activity with changes in the levels of C-reactive protein and mucoprotein. The NoCoV-2-Prof group showed significantly elevated plasma cortisol levels. To our kowledge, this study is the first to report the use of the RT-LAMP method with the saliva samples of health professionals, to evalute of SARS-CoV-2.

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“…SARS-CoV-2 transmission is mainly mediated by saliva droplets [ 16 ]. The FDA has approved saliva as a source of virus detection.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Trassante¹,

Barboza²,

Rocha³

et al. 2021

Microbial Pathogenesis

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show abstract

“…The role of G6PDd on viral diseases may result from its potential role in oxidative stress metabolism, which also of relevance in the case of COVID-19 disease [ 94 , 95 ]. Since G6PDd results in the redox imbalance in the erythrocytes, due to hemolysis and tissue damage originated from insufficient oxygen transportation, G6PDd might be a risk factor for those infected by SARS-CoV-2 [ 3 , 94 , 96 , 97 ].…”

Section: Glucose-6-phosphate Dehydrogenase Deficiency As a Populamentioning

confidence: 99%

Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach

et al. 2021

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To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes.

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“…Limited access to clean water and insufficient water consumption are the important factors that causes oxidative stress formation. Clean and sufficient water consumption is highly important during the period when the body struggles with oxidative stress using many molecules grouped in enzymatic systems (30).…”

Section: Effect Of Water Consumption On Immune System Responsementioning

confidence: 99%

Effect of water consumption over the immune system response given during Covid-19

Özkaya¹,

Yıldız²

2021

Magna Sci. Adv. Res. Rev.

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Immune system, is the reactions initiated by the body to detect components, called antigens, with a different structure from its own genetic and to destroy those components. To have a strong and healthy immune system, a healthy diet is needed. Immune system also needs water to work properly and effectively. When the contents of diet suggestions published are observed during the COVID-19 pandemia FAO (2020) informs that regular plenty of water consumption will help our immune system. Water is also very important for hygiene in the context of the spread and control of COVID-19. Adequate water supply must be provided for meeting the basic water need, prevention from diseases, successful disease treatment during the illness and general health. Clean water usage, access to clean and adequate water are one of the most significant steps in the world in improving child-adult health.

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The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Cited by 44 publications

References 100 publications

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach

Effect of water consumption over the immune system response given during Covid-19

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