Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats

Silva, Amadeu Zattoni da; Costa, Felipe Pereira; Souza, Ingrid L.M.; Ribeiro, Mariana Costa; Giordani, Morenna Alana; Queiroz, Diogo Albino de; Luvizotto, Renata de Azevedo Melo; Nascimento, André Ferreira do; Bomfim, Gisele Facholi; Sugizaki, Mário Mateus; Dekker, Robert F. H.; Barbosa-Dekker, Aneli M.; Queiroz, Eveline Aparecida Isquierdo Fonseca de

doi:10.1016/j.lfs.2018.09.027

Cited by 22 publications

(28 citation statements)

References 54 publications

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“…As observed in our previous study (Luvizotto et al, 2010), the DIO group Hibiscus sabdariffa ethanolic extract demonstrated decreased food intake, but higher energy intake than the C group. The experimental model efficiently promoted obesity, as demonstrated by a higher BW when compared to the C group (Table 2), as previously reported (Francisqueti et al, 2017;Silva et al, 2018). The increase in BW, especially in adipose tissue, occurs because the augmented fat consumption is not accompanied by a proportional increase in fat oxidation, leading to the deposition of fat as TG in adipose tissues (Rogero and Calder, 2018;Longo et al, 2019).…”

Section: Discussionsupporting

confidence: 79%

“…The experimental diet was a high-fat chow (24.5% fat; 480 kcal/100 g), with sugar added to the drinking water (300 g/L; 1.2 kcal/mL). The high-fat diet model has been adapted from our previous study (Nascimento et al, 2008;Silva et al, 2018), which was used to simulate obesity attributed to occidental dietary patterns.…”

Section: Chows Nutritional Compositionmentioning

confidence: 99%

“…The serum was used for the analysis of TG (Analisa V R , Cat# 459, Belo Horizonte, MG, Brazil), total cholesterol (AnalisaV R , Cat# 460, Belo Horizonte, MG, Brazil) and high-density lipoprotein (HDL) cholesterol (AnalisaV R , Cat# 413, Belo Horizonte, MG, Brazil), determined spectrophotometrically. Very low-density lipoprotein (VLDL) cholesterol and low-density lipoprotein (LDL) cholesterol were evaluated using the formula as previously reported (Silva et al, 2018). The oral glucose tolerance test was performed with blood samples collected from the caudal vein, as previously described (Silva et al, 2018).…”

Section: Lipid and Glycemic Profilesmentioning

confidence: 99%

“…Very low-density lipoprotein (VLDL) cholesterol and low-density lipoprotein (LDL) cholesterol were evaluated using the formula as previously reported (Silva et al, 2018). The oral glucose tolerance test was performed with blood samples collected from the caudal vein, as previously described (Silva et al, 2018). The oral glucose tolerance test was analyzed using the area under the curve (AUC) for glucose.…”

Section: Lipid and Glycemic Profilesmentioning

confidence: 99%

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Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Dentz

Silva

Queiroz

et al. 2020

NFS

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Purpose The purpose of this study is to evaluate the effect of Hibiscus sabdariffa ethanolic extract (HsE) on protein levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, adiponectin and leptin in adipose tissue, as well as on the lipid and glycemic profiles of high-fat/sugar diet-induced obese (DIO) rats. Design/methodology/approach Obesity was induced in male Wistar rats through a high-fat/sugar diet provided for eight weeks. Control rats received a standard diet. The high-fat/sugar DIO animals were subsequently randomized into DIO (n = 8) and DIO treated with HsE (DIO + HsE, n = 8, 150 mg/kg/day) by gavage, for additional eight weeks. Oral glucose tolerance test was performed, and blood samples and epididymal adipose tissue were collected for biochemical analysis and adipokine protein level evaluation, respectively. Findings Compared to the DIO rats, HsE treatment decreased weight gain (50.6%) and mesenteric fat (42%), indicated as diminished visceral fat (22.5%). HsE did not affect the lipid profile and TNF-α levels in adipose tissue; however, it effectively prevented a 13% increase in fasting glucose levels and improved glucose tolerance. Compared with the C group, HsE normalized the adiponectin levels and leptin/adiponectin ratio and decreased the IL-6 (55%) and leptin (18.6%) levels in adipose tissue of obese rats. Originality/value HsE improves adipokine protein levels in high-fat/sugar DIO rats, demonstrating the clinical efficacy of HsE in the treatment of obesity and obesity-related diseases.

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Section: Discussionsupporting

confidence: 79%

Section: Chows Nutritional Compositionmentioning

confidence: 99%

Section: Lipid and Glycemic Profilesmentioning

confidence: 99%

Section: Lipid and Glycemic Profilesmentioning

confidence: 99%

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Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Dentz

Silva

Queiroz

et al. 2020

NFS

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“…al., 2008). Alguns exemplos de agentes promotores são componentes nitritos e nitratos presentes na alimentação, álcool, tabaco, a exposição excessiva e prolongada a hormônios, como o estrogênio, dentre outros (SILVA et al, 2018;INCA, 2019).…”

Section: Câncerunclassified

Obesidade e câncer: mecanismos envolvidos e intervenções terapêuticas

et al. 2022

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A transição demográfica iniciada no Brasil, a partir da década de 60, promoveu mudanças nos hábitos de vida da população, promovendo alterações no perfil nutricional e nas manifestações de doenças. No início do século XXI, ocorreu um marco no qual, pela primeira vez, o número de indivíduos com excesso de peso ultrapassou os de baixo peso, o que é preocupante, pois a obesidade é apontada como um dos principais fatores de risco para inúmeras patologias crônicas, incluindo diabetes, dislipidemia, doenças cardiovasculares e inúmeros tipos de câncer. A incidência e a mortalidade por câncer vêm aumentando no mundo, em parte devido ao envelhecimento e crescimento populacional, mas também pela mudança da distribuição e prevalência dos fatores de risco relacionados ao câncer. Vários fatores como mudanças metabólicas ou hormonais, influenciadas pelo aumento do tecido adiposo, resistência à insulina, hiperinsulinemia, inflamação crônica de baixo grau, maior biodisponibilidade de hormônios e estresse oxidativo, contribuem para os mecanismos de carcinogênese na obesidade. A alimentação balanceada, além de contribuir para o controle de peso, pode exercer o papel protetor em relação à carcinogênese. Há pesquisas em andamento que avaliam o potencial de vegetais verdes-escuros, alaranjados, crucíferos (repolho, brócolis, couve de Bruxelas), produtos de soja, feijão (carioca, preto, branco, vermelho), legumes, cebola, alho e tomate na prevenção do câncer. Outro fator importante é a prática regular de atividade física, que diminui o risco de câncer por melhorar a sensibilidade à insulina, o que estimula a imunidade e diminui os níveis de adipocina e marcadores inflamatórios. Dessa forma, esta revisão tem como objetivo analisar e relacionar informações associadas com a obesidade e o câncer.

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Antioxidant, anti‐inflammatory and beneficial metabolic effects of botryosphaeran [(1→3)(1→6)‐β‐d‐glucan] are responsible for its anti‐tumour activity in experimental non‐obese and obese rats bearing Walker‐256 tumours

Silva

Geraldelli

Martins

et al. 2022

Cell Biochemistry & Function

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Botryosphaeran, a (1!3)(1!6)-β-D-glucan, presents several beneficial activities, such as antiproliferative, hypoglycemic and antitumoural activities. This study evaluated the effects of botryosphaeran on oxidative stress, inflammation and metabolic activities in Walker-256 tumour-bearing non-obese and obese rats. Wistars rats were divided into four groups: control tumour (CT); control tumour + botryosphaeran (CTB); obese tumour (OT), and obese tumour + botryosphaeran (OTB). In ninth week, obese and non-obese rats were inoculated with 1 Â 10 7 Walker-256 tumour cells and treated with botryosphaeran (30 mg/kg/d for 15 days). In 11th week, the following parameters were evaluated glycogen, glucose and lactate levels, pro-oxidant (TBARS) and antioxidant markers (superoxide dismutase [SOD]; catalase [CAT]; glutathione-S-transferase [GST]; reduced glutathione [GSH]; vitamin C) and cytokines. Obesity presented oxidative stress and inflammation, as demonstrated by high levels of TBARS, SOD and TNF-α, and lower levels of CAT, GSH and interleukin-10 (IL-10). Botryosphaeran significantly decreased TBARS and TNF-α and increased GST, GSH, vitamin C and IL-10 in the liver; increased SOD and vitamin C in tumour tissue; decreased TBARS in adipose tissue, and notably decreased the levels of glycogen and lactate in the tumour of CTB rats. Botryosphaeran promoted significant antioxidant, anti-inflammatory, and beneficial metabolic effects in Walker-256 tumour-bearing non-obese and obese rats, which contributed to its antitumour activity.

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Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats

Cited by 22 publications

References 54 publications

Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Hibiscus sabdariffa ethanolic extract modulates adipokine levels, decreases visceral fat and improves glycemic profile in high-fat/sugar diet-induced obese rats

Obesidade e câncer: mecanismos envolvidos e intervenções terapêuticas

Antioxidant, anti‐inflammatory and beneficial metabolic effects of botryosphaeran [(1→3)(1→6)‐β‐d‐glucan] are responsible for its anti‐tumour activity in experimental non‐obese and obese rats bearing Walker‐256 tumours

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