Research Progress of Raman Spectroscopy in Drug Analysis

Abstract

Raman spectroscopy is a spectroscopic analysis technique that enables rapid qualitative and quantitative detection based on inelastic collision and Raman scattering intensity. This review detailed the generation principle, instrument composition, influencing factors, and common classifications of Raman spectrum. Furthermore, it summarized and forecast the research progress of Raman spectroscopy in the field of drug analysis simultaneously over the past decade, including the identification of active pharmaceutical ingredients (APIs), qualitative and quantitative studies of pharmaceutical preparations, detection of illicit drugs, the identification of Chinese herbal medicines, and the combination with other technologies. The development of Raman spectroscopy in other fields is additionally summarized.

Surface plasmon resonance, Orbitrap mass spectrometry and Raman advancements: exciting new techniques in drug discovery

“…However, its increasing usage can be attributed to recent advancements i.e. [13][14][15]. These advancements make Raman a unique and powerful technique for both qualitative and quantitative analysis of newly synthesized compounds and their characterization in both drug discovery and development stages with high accuracy and sensitivity.…”

Application and Progress of Raman Spectroscopy in Male Reproductive System

“…Raman scattering is divided into two types: when the frequency of scattered light is less than the frequency of excited light, it is called Stokes Raman scattering; if the frequency of scattered light is greater than that of excited light, it is called anti-Stokes Raman scattering. Different from Raman scattering, Rayleigh scattering is a kind of elastic scattering, which means the frequency of scattered and excited light are equal ( Wang et al, 2018 ) ( Figure 1A ).…”

“…), spectrometer, detector (i.e. CCD detector) and computer processing system ( Mallidis et al, 2014 ; Cordero et al, 2018 ; Wang et al, 2018 ) ( Figure 1B ). The common confocal micro-Raman spectrometer used commonly in the market is the coupling of Raman spectrometer and optical microscope, which can greatly improve the horizontal and vertical spatial resolution to realize the analysis of micron-scale samples ( Meister et al, 2010 ; Huang et al, 2014 ; Gomes da Costa et al, 2019 ).…”

Perspective of Future SERS Clinical Application Based on Current Status of Raman Spectroscopy Clinical Trials

“…In the progress of light scattering, most photons maintain the same energy and wavelength after interacting with matter ( Raman and Krishnan, 1928 ; Auner et al, 2018 ). But a very small portion of photons is linearly inelastically scattered, resulting in loss of energy, and a longer wavelength ( Raman and Krishnan, 1928 ; Wang et al, 2018 ). The shift of the wavelength is called Raman shift, which is inversely proportional to the change in the photons’ wavelength ( Jones et al, 2019 ).…”