Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth

Roth, Daniel; Morris, Shaun K.; Zlotkin, Stanley; Gernand, Alison D.; Ahmed, Tahmeed; Shanta, Shaila S; Papp, Eszter; Korsiak, Jill; Shi, Julie; Islam, M Munirul; Jahan, Ishrat; Keya, Farhana K; Willan, Andrew R.; Weksberg, Rosanna; Mohsin, Minhazul; Rahman, Qazi Sadeq Ur; Shah, Prakesh S.; Murphy, Kellie; Stimec, Jennifer; Pell, Lisa G; Qamar, Huma; Mahmud, Abdullah Al

doi:10.1056/nejmoa1800927

Cited by 170 publications

(237 citation statements)

References 26 publications

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“…At 34 weeks of gestation, frequency of vitamin D sufficiency in the 2,000‐IU/d group was 1.8 times higher than in the 1,000‐IU/d group. This finding was similar to that of other trials that examined the effectiveness of the same doses of vitamin D supplementation (Cooper et al, ; De‐Regil, Palacios, Lombardo, & Pena‐Rosas, ; Grant et al, ; Hollis, Johnson, Hulsey, Ebeling, & Wagner, ; Roth et al, ; Sahoo, Katam, Das, Agarwal, & Bhatia, ; Zerofsky, Jacoby, Pedersen, & Stephensen, ). Pregnancy‐induced increased body fat mass and hemodilution may explain to some extent the increased vitamin D need of a pregnant woman.…”

Section: Discussionsupporting

confidence: 87%

“…Supplementation started from 17 to 24 weeks of gestation until birth or 6‐month postpartum. In this study, despite remarkable increase in circulating calcidiol (from initially 23 nmol/L to finally 69–114 nmol L −1 , depending on the supplementation dose), birth sizes did not differ significantly among different supplementation groups (Roth et al, ). Late commencement of supplementation in this study may, at least in part, explain the unresponsiveness of birth sizes to vitamin D supplementation.…”

Section: Discussionmentioning

confidence: 50%

“…The present investigation found that the occurrence of preeclampsia, gestational diabetes, preterm birth, SGA, and caesarean section were not different between groups. The effect of vitamin D supplementation on the pregnancy outcomes including preeclampsia, gestational diabetes, and spontaneous abortion has not been confirmed by several RCTs (Asemi, Karamali, & Esmaillzadeh, ; Karamali, Asemi, Ahmadi‐Dastjerdi, & Esmaillzadeh, ; Perez‐Lopez et al, ; Roth et al, ). Nonetheless, there are few interventional studies with large sample size that support the positive effect of vitamin D supplementation during pregnancy on pregnancy outcomes (De‐Regil et al, ).…”

Section: Discussionmentioning

confidence: 98%

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Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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Hypovitaminosis D during pregnancy is suggested to have a link with complications in both mother and infant. We aimed to evaluate the efficacy of two doses of vitamin D3 supplementation during pregnancy on maternal and cord blood vitamin D status, inflammatory biomarkers, and maternal and neonatal outcomes. A total of 84 pregnant women (gestational age of <12 weeks) were randomly allocated to one of two groups: (a) 1,000‐IU/d vitamin D and (b) 2,000 IU/d. Biochemical assessments (25‐hydroxycalciferol (25(OH)D), hs‐CRP, and cell‐culture supernatant concentrations of IL‐1β, IL‐6, and TNF‐α) of mothers were performed at the beginning and 34 weeks of gestation. Assessments of infants at delivery comprised cord blood serum concentrations of 25(OH)D, hs‐CRP, IL‐1β, IL‐6, TNF‐α, birth sizes, and Apgar score. Circulating concentrations of 25(OH)D increased in both intervention groups with more increment in 2,000 IU/d than in 1,000 IU/d (46.7 ± 30.7 vs. 24.0 ± 21.07 nmol L−1, P = .001). Concentrations of TNF‐α decreased significantly in group 2,000 (−913.1 ± 1261.3 ng L−1, P = .01). The cord blood concentration of IL‐6 in group 2,000 IU/d, compared with 1,000 IU/d, was significantly lower (25.9 ± 32.0 vs. 4.6 ± 1.4 ng L−1, P = .03). The birth sizes including weight, length, and head circumference of the infants of group 2,000 IU/d were significantly higher than the infants' of group 1,000 IU/d. Supplementation with 2,000‐IU/d vitamin D3 is more effective than 1,000 IU/d in pregnant women in terms of increasing circulating 25(OH)D, ameliorating pro‐inflammatory markers notably TNF‐α in mother and IL‐6 in cord blood, and improving neonatal outcomes including the birth sizes.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 98%

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Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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“…GA, gestational age; LBW, low birth weight; SGA, small-for-gestational age; UA, umbilical artery. 14 Fawzi (1998) 15 Goffinet (2001) 16 Harrington (2000) 18 Kupka (2008) 24 Janmohamed (2016) 20 Kokanali (2014) 21 Kumwenda (2002) 22 Lagendijk (2018) 25 Levine (1997) 26 Metcoff (1985) 27 Moses (2014) 28 Newnham (2009) 29 Parazzini (1993) 32 Poston (2015) 33 Ramakrishnan (2003) 36 Rodger (2014) 37 Rolnik (2017) 38 Roth (2018) 39 Siega-Riz (2006) 40 Steketee (1996) 42 Subramanian (2012) 43 Sureau (1991) 44 Toe (2015) 46 Villar (1992) 48 Villar (2009) 49…”

Section: Clinical and Research Implicationsmentioning

confidence: 99%

Variation in outcome reporting in randomized controlled trials of interventions for prevention and treatment of fetal growth restriction

Townsend

Sileo

Stocker

et al. 2019

Ultrasound in Obstet & Gyne

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Objective Although fetal growth restriction (FGR) is well known to be associated with adverse outcomes for the mother and offspring, effective interventions for the management of FGR are yet to be established. Trials reporting interventions for the prevention and treatment of FGR may be limited by heterogeneity in the underlying pathophysiology. The aim of this study was to conduct a systematic review of outcomes reported in randomized controlled trials (RCTs) assessing interventions for the prevention or treatment of FGR, in order to identify and categorize the variation in outcome reporting. Methods MEDLINE, EMBASE and The Cochrane Library were searched from inception until August 2018 for RCTs investigating therapies for the prevention and treatment of FGR. Studies were assessed systematically and data on outcomes that were reported in the included studies were extracted and categorized. The methodological quality of the included studies was assessed using the Jadad score. Results The search identified 2609 citations, of which 153 were selected for full‐text review and 72 studies (68 trials) were included in the final analysis. There were 44 trials relating to the prevention of FGR and 24 trials investigating interventions for the treatment of FGR. The mean Jadad score of all studies was 3.07, and only nine of them received a score of 5. We identified 238 outcomes across the included studies. The most commonly reported were birth weight (88.2%), gestational age at birth (72.1%) and small‐for‐gestational age (67.6%). Few studies reported on any measure of neonatal morbidity (27.9%), while adverse effects of the interventions were reported in only 17.6% of trials. Conclusions There is significant variation in outcome reporting across RCTs of therapies for the prevention and treatment of FGR. The clinical applicability of future research would be enhanced by the development of a core outcome set for use in future trials. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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“…This study was based on cord blood samples collected in the Maternal Vitamin D for Infant Growth (MDIG) study trial of 1300 pregnant women in Dhaka, Bangladesh, which has been previously described (Roth et al 2015). Briefly, the MDIG trial is a randomized, placebo-controlled, doseranging trial of maternal vitamin D supplementation during pregnancy and lactation on infant length at 1 and 2 years of age.…”

Section: Study Areamentioning

confidence: 99%

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

et al. 2018

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Information about the human burdens of persistent organic pollutants (POPs) in low-and middle-income countries is limited. In particular, studies often include only a small subset of POPs. To address this data gap, we aimed to assess maternal-child exposures to POPs in Dhaka, Bangladesh. We quantified 16 organochlorine pesticides, 12 polychlorinated biphenyls, 21 brominated flame retardants, 18 per-and polyfluorinated alkyl substances, 2 polycyclic aromatic hydrocarbons, and short-chain chlorinated paraffins in 18 pooled samples of human cord blood from 90 mother-infant pairs living in Dhaka, Bangladesh (2014. In all pooled samples, we detected high levels of p,p′-DDT (median 81.6 ng/g lipid) and its metabolites p,p′-DDE and p,p′-DDD (median 551 and 10.7 ng/g lipid, respectively), where the p,p′-DDE/p,p′-DDT ratio ranged from 2.9 to 9.8 indicating recent dichlorodiphenyltrichloroethane (DDT) exposure. We also detected acenaphthene, decabromodiphenyl ethane, o,p′-DDT, o,p′-DDE, hexachlorobenzene, β-hexachlorocyclohexane, hexabromobenzene, and perfluorooctanoic acid in a subset of samples. For the other 59 target compounds, concentrations were below the limits of detection, despite using ultra-trace analytical methodology. No trends were observed when stratifying the analyses of detected POP concentrations by maternal age, maternal body mass index, or large fish consumption. These findings highlight recent DDT exposure in Dhaka, but the overall POP burden was otherwise low in this sample of pregnant women/newborns. Future monitoring efforts should focus on newly detected POPs for which burdens may be increasing due to ongoing industrialization in Bangladesh.

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Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth

Cited by 170 publications

References 26 publications

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Variation in outcome reporting in randomized controlled trials of interventions for prevention and treatment of fetal growth restriction

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

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