Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

Lee, Sharon Wei Ling; Adriani, Giulia; Ceccarello, Erica; Pavesi, Andrea; Tan, Anthony T.; Bertoletti, Antonio; Kamm, Roger D.; Wong, Siew Cheng

doi:10.3389/fimmu.2018.01719

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Mps-based Assays For Testing Biological Products1

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Cited by 11 publications

(1 citation statement)

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“…This platform enabled the investigation of how human primary monocytes influence the killing efficacy of HBV-specific TCR T cells generated through several methods and analyzed the role of PD-L1/PD-1 expression during their interactions. 59 Overall, these MPS-based assays may contribute to enhancing the potency evaluation strategy by incorporating additional physiologically relevant cells and structures that were not feasible in traditional assays.…”

Section: Mps-based Assays For Testing Biological Productsmentioning

confidence: 99%

Progress in developing microphysiological systems for biological product assessment

Mansouri,

Lam,

Sung

2024

Lab Chip

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Section: Mps-based Assays For Testing Biological Productsmentioning

confidence: 99%

Progress in developing microphysiological systems for biological product assessment

Mansouri,

Lam,

Sung

2024

Lab Chip

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Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development

Kim

Habbit

et al. 2019

Adv Funct Materials

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Tumor cell heterogeneity with distinct phenotypes, genotypes, and epigenetic states as well as the complex tumor microenvironment is major challenges for cancer diagnosis and treatment. There have been substantial advances in our knowledge of tumor biology and in the capabilities of available biological analysis tools; however, the absence of physiologically relevant in vitro testing platforms limits our ability to gain an in-depth understanding of the role of the tumor microenvironment in cancer pathology. In this review, recent advances in engineered tumor microenvironments to advance cancer research and drug discovery are presented, including tumor spheroids, microfluidic chips, paper scaffolds, hydrogel-based engineered tissues, 3D bioprinted scaffolds, and multiscale topography. Furthermore, how these technologies address the specific characteristics of the native tumor microenvironment is described. Through the comparison of these biomimetic 3D tumor models to conventional 2D culture models, the validity and physiological relevance of these platforms for fundamental in vitro studies of the tumor biology, as well as their potential use in drug screening applications, is also discussed.

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Models for Monocytic Cells in the Tumor Microenvironment

Lee

Adriani

Kamm

et al. 2020

Advances in Experimental Medicine and Biology

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Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

Cited by 11 publications

References 0 publications

Progress in developing microphysiological systems for biological product assessment

Progress in developing microphysiological systems for biological product assessment

Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development

Models for Monocytic Cells in the Tumor Microenvironment

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