Progress in developing microphysiological systems for biological product assessment

Mansouri, Mona; Lam, Johnny; Sung, Kyung E.

doi:10.1039/d3lc00876b

Cited by 5 publications

(1 citation statement)

References 92 publications

(105 reference statements)

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“…Despite the growth of the MPS industry over the past two decades, these systems have not yet gained overwhelming traction in the pharmaceutical sector, largely in part due to the lack of supportive datasets and the time and monetary investments required by pharmaceutical companies to assess the overall value of the technology [ 118 ]. Verification and validation of MPS for safety and efficacy of anticancer drugs required from the U.S. Food and Drug Administration (FDA) in clinical trials are not as defined as for animal studies [ 119 ]. Guidelines for the verification/validation of MPS will be critical to standardizing the systems now that MPS has been cleared to replace animal research in preclinical studies.…”

Section: Discussionmentioning

confidence: 99%

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Hamel,

Frazier,

Williams

et al. 2024

IJMS

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Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with a continuing increase in incidence despite efforts to discover new targeted therapies. With an approximate failure rate of 85% for therapies in the early phases of clinical trials, there is a need for more translatable, new preclinical in vitro models that include cellular heterogeneity, extracellular matrix, and human-derived biomaterials. Specifically, adipose tissue and its resident cell populations have been identified as necessary attributes for current preclinical models. Adipose-derived stromal/stem cells (ASCs) and mature adipocytes are a normal part of the breast tissue composition and not only contribute to normal breast physiology but also play a significant role in breast cancer pathophysiology. Given the recognized pro-tumorigenic role of adipocytes in tumor progression, there remains a need to enhance the complexity of current models and account for the contribution of the components that exist within the adipose stromal environment to breast tumorigenesis. This review article captures the current landscape of preclinical breast cancer models with a focus on breast cancer microphysiological system (MPS) models and their counterpart patient-derived xenograft (PDX) models to capture patient diversity as they relate to adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Hamel,

Frazier,

Williams

et al. 2024

IJMS

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An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

Parihar,

Sunildutt,

Rahim

et al. 2024

Advanced Therapeutics

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Vascularized tumor on a chip (VToC) entails emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient responses to therapies. Compared to conventional ones, VToC systems hold advantages by creating a milieu where physiological conditions for investigating tumor‐host interactions are pivotal in tumor advancement/therapy resilience. Nevertheless, VToC models confront limitations encompassing vascular network replication, biological fidelity, mechanical/chemical integrity, and intricacies of architectural design. Thus, drawbacks inherent to prevailing VToC models' intricacies, attributes, and vascular network establishment are imperative. This systematic review focuses on the recent advancements, technologies explored for incorporating VToC models, & vascularization approaches for investigation, and factors/parameters affecting complex tumor microenvironments in VToC models, along with the futuristic approach for the design strategies, fabrication techniques, understanding of vascular network, also VToC models with spheroid. A comprehensive analysis of VToC based on their limitations for a practical approach highlights the promising strategies for possible applications. This review will be essential regarding a complete overview of VToC models and the future direction toward developing efficient VToC models compared to the state‐of‐the‐art VToC.This article is protected by copyright. All rights reserved

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A Review on Multicellular Spheroids and Organoids for Breast Cancer Diagnosis and Therapy

Jadhav,

Rath,

Roopavath

2024

Biomedical Materials & Devices

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Progress in developing microphysiological systems for biological product assessment

Abstract: This review delves into microphysiological systems, miniature physiological environments used to evaluate biological products, reducing the need for animal experimentation. We consider their benefits as well as persistent challenges in material selection/fabrication and reproducibility.

Cited by 5 publications

References 92 publications

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

A Review on Multicellular Spheroids and Organoids for Breast Cancer Diagnosis and Therapy

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