Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

“…Lindl. Procyanidin B2 could inhibit acute lung injury in rat model of ALI induced by paraquat via the inhibition of MDA activity and expression of inflammatory mediators TNF-a, IL-1β and IL-18 [ 311 ]. Further study found that procyanidin B2 significantly increased cell viability in LPS-treated human alveolar epithelial cells and lung fibroblasts, and suppressed LPS-induced cell apoptosis, which were associated with reduced Bax expression and promoted Bcl-2 expression.…”

Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?

“…The proposed mechanism is thought to be via inhibition of p65 nuclear expression and DNA binding, resulting in the transcriptional repression of target genes, such as COX2, iNOS and production of IL-6, IL-18, IL-1β and NO (Martinez-Micaelo et al, 2015). Furthermore, procyanidins decrease the ASC and caspase-1 signalling, which consequently leads to less activation of NLRP3 (Jiang et al, 2018). Procyanidins have been shown to attenuate experimental colitis in vivo, by suppressing NF-κB and NLRP3 signaling expression in colon tissue in mice (Chen et al, 2018).…”

Role of NLRP3 Inflammasome in Lupus Nephritis and Therapeutic Targeting by Phytochemicals

“…PCB2 is a bioactive phenolic compound isolated from apples, cocoa, and grapes. Previous research found that it holds diverse properties, such as modulation of the gut microbiota and anti-inflammatory and antioxidant effects ( Su H. et al, 2018 ; Jiang et al, 2018 ; Endo et al, 2020 ). Recent evidence demonstrated that PCB2 directly represses the NLRP3 gene ( He et al, 2018 ).…”