Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?

Alvarenga, Livia; Cardozo, Ludmila F M F; Borges, Natália Alvarenga; Lindholm, Bengt; Stenvinkel, Peter; Shiels, Paul G.; Fouque, Denis; Mafra, Denise

doi:10.1016/j.foodres.2020.109306

Cited by 16 publications

(10 citation statements)

References 178 publications

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“…Among all these different metabolites that are important for their health benefits, the phenolic compounds have been studied most extensively [ 190 , 191 ]. These constituents, with more than 5000 structurally diverse molecules of various types, are the most numerous, abundant, and widely distributed “bioactive compounds”, very important for their potential beneficial effects, which are also associated with inflammasome disorder in diseases [ 1 , 17 , 53 , 190 , 192 ]. Many of these positive effects on safety and efficacy have been studied in vitro and on animal models and have yet to be confirmed with absolute certainty on humans with clinical trials [ 193 , 194 , 195 ].…”

Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

“…It is well known that the “bioactive compounds”, whatever their origin (from animals or plants source), due to the food complexity and in order to exert their beneficial health action, need to be released from the food matrix after ingestion, and then metabolized [ 196 ]. As different researchers highlighted, the global food matrix composition, with the presence of nutrient interaction, has a crucial role on the health benefit of “bioactive compounds”; however, some other specific characteristics can determine the biological activity of these metabolites [ 17 , 197 ]. The factors that influence the absorption and bioavailability of “bioactive compounds” are numerous, one of these is represented by the cell wall structure and properties, since, often, they are resistant to degradation in the upper gut [ 196 ].…”

Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

“…Furthermore, NLRP3 inflammasome can also be activated by different endogenous risk agents, such as palmitic acid, amyloid β, and cholesterol crystals [ 16 ]. So, NLRP3 inflammasome intervening in such responses is associated with the development of several lifestyle-related chronic diseases, characterized by persistent inflammation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

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Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound.

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Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

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“…Tiny molecular compounds derived from natural products have shown potential therapeutic effects on CKD, as indicated in previous reports [109][110][111][112]. These compounds have antioxidant [113], anti-inflammatory [114], and immunomodulatory [115] activities that are linked to their disease alleviative property.…”

Section: Small Bioactive Compounds Against Ckdmentioning

confidence: 74%

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease

2021

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Chronic kidney disease (CKD) is the progressive loss of renal function and the leading cause of end-stage renal disease (ESRD). Despite optimal therapy, many patients progress to ESRD and require dialysis or transplantation. The pathogenesis of CKD involves inflammation, kidney fibrosis, and blunted renal cellular antioxidant capacity. In this review, we have focused on in vitro and in vivo experimental and clinical studies undertaken to investigate the mechanistic pathways by which these compounds exert their effects against the progression of CKD, particularly diabetic nephropathy and kidney fibrosis. The accumulated and collected data from preclinical and clinical studies revealed that these plants/bioactive compounds could activate autophagy, increase mitochondrial bioenergetics and prevent mitochondrial dysfunction, act as modulators of signaling pathways involved in inflammation, oxidative stress, and renal fibrosis. The main pathways targeted by these compounds include the canonical nuclear factor kappa B (NF-κB), canonical transforming growth factor-beta (TGF-β), autophagy, and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid factor 2-related factor 2 (Nrf2)/antioxidant response element (ARE). This review presented an updated overview of the potential benefits of these antioxidants and new strategies to treat or reduce CKD progression, although the limitations related to the traditional formulation, lack of standardization, side effects, and safety.

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“…Inflammasomes are multiprotein cytoplasmic complexes from the innate immune system, formed in response to stimuli of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), in response to infections, tissue damage or cell stress. The inflammasomes promote the activation of Caspase-1, which through cleavages of IL -1β and IL-18, will give rise to its mature forms leading to local and systemic inflammatory reactions (Kelley et al 2019;Alvarenga et al 2020). Surprisingly, inflammasome inhibition by SFN seems to be independent of the transcription factor Nrf2 and the antioxidant response-element pathway.…”

Section: Sulforaphane: Effects On Nrf2 and Inflammationmentioning

confidence: 99%

Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease

et al. 2020

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Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. Patients with chronic diseases, such as diabetes, cardiovascular disease, cancer, and chronic kidney disease (CKD) present with high levels of oxidative stress and a massive inflammatory burden associated with diminished Nrf2 and elevated nuclear transcription factor-κB-κB expression. Because it is a common constituent of dietary vegetables, the salutogenic properties of sulforaphane, especially it’s antioxidative and anti-inflammatory properties, have been explored as a nutritional intervention in a range of diseases of ageing, though data on CKD remain scarce. In this brief review, the effects of SFN as a senotherapeutic agent are described and a rationale is provided for studies that aim to explore the potential benefits of SFN-rich foods in patients with CKD.

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Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?

Abstract: The material cannot be used for any other purpose without further permission of the publisher and is for private use only.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.

Cited by 16 publications

References 178 publications

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease

Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease

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