3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer

Caruso, Maria Gabriella; Notarnicola, Maria; Cavallini, A; Leo, Alfredo Di

doi:10.1007/s005350200078

Cited by 38 publications

(21 citation statements)

References 21 publications

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“…High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase [21], farnesyl pyrophosphate synthase [22] and farnesyltransferase [23] have been found in human colon cancers; therefore, we suggested a key role of these enzymes in the process of colon malignant transformation. In addition, we have demonstrated that overexpression of these enzymes is associated with some genetic alterations commonly involved (such as K-ras and p53 gene mutations) in colon cancer development [24].…”

Section: Introductionmentioning

confidence: 99%

“…Recent epidemiological studies have shown an association between obesity and functional bowel disorders [17, 18], pointing to obesity as a risk factor for colorectal cancer due to chronic inflammation of colon tissue [19]. All this evidence led us to study the activity and gene expression of FAS, a critical enzyme involved in human colorectal cancer, in which other enzymes of the lipid pathway have already been studied [20,21,22,23]. …”

Section: Introductionmentioning

confidence: 99%

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Fatty Acid Synthase Hyperactivation in Human Colorectal Cancer: Relationship with Tumor Side and Sex

Notarnicola¹,

Altomare

Calvani

et al. 2006

Oncology

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Objective: Fatty acid synthase (FAS) is a multienzyme protein required for the conversion of acetyl coenzyme A and malonyl coenzyme A to palpitate. High levels of FAS expression have been found in many human cancers, including breast, prostate and colon. In this study, we evaluated FAS activity levels and the expression of its mRNA in normal colorectal mucosa and cancer tissue from patients operated for colorectal carcinoma. In addition, the hypothesis of a relation between FAS activity and p53 mutation status of patients was tested. Methods: Forty-two patients were enrolled in the study. FAS activity was measured by using a radiometric assay. FAS gene expression was determined using quantitative reverse-transcription polymerase chain reaction and p53 mutations by polymerase chain reaction single-strand conformation polymorphism. Results: FAS activity levels were significantly higher in cancer than in the corresponding normal mucosa. Tumors located on the left side of the colon showed higher levels of FAS activity and tumors from male patients showed higher FAS activity than tumors from females. No difference was detected in mRNA FAS levels according to tumor side and gender. Moreover, lower levels of FAS activity were detected in patients carrying the p53 mutation. Conclusions: This study suggests that biological factors including sex and gene mutation status, as well as stratification of patients with colorectal cancer into right- and left-sided subsets, may be important in patient selection for targeted therapies and for the subsequent assessment of objective therapeutic responses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fatty Acid Synthase Hyperactivation in Human Colorectal Cancer: Relationship with Tumor Side and Sex

Notarnicola¹,

Altomare

Calvani

et al. 2006

Oncology

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“…In a randomized prospective controlled trial, RYR, in comparison to a placebo, decreased total cholesterol, triglycerides, and apolipoprotein B in hypercholesterolemic individuals (Lin et al 2005). Cholesterogenesis is a key factor for tumor growth and HMG-CoA reductase activities are up-regulated in colon tumors (Buchwald 1992;Hentosh et al 2001;Notarnicola et al 2004;Caruso et al 2002). The pharmacological evidences showed that statins may inhibit colon cancer cell growth and thereby reduces incidence of colon cancer (Agarwal et al 2002;Ukomadu and Dutta 2003;Lin et al 2006).…”

Section: Effect Of Ryr In the Treatment Of Cancermentioning

confidence: 94%

Health Benefits and Clinical Impact of Major Nutrient, Red Yeast Rice: A Review

Kalaivani¹,

Sabitha²,

Kalaiselvan³

et al. 2009

Food Bioprocess Technol

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Chinese red yeast rice (RYR), a natural food obtained after fermenting rice with Monascus purpureus. RYR contains unsaturated fatty acids, sterols, B-complex vitamins and monacolins with antioxidant properties. Scientific evidences showed that fermented RYR proved to be effective for the management of cholesterol, diabetes, cardiovascular disease (CVD) and also for the prevention of cancer. This review article describe about the usage of RYR in human being.

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“…In particular, low serum HDL-cholesterol was reported to be a negative prognostic factor for gastric adenocarcinoma patients (26). Low-density lipoprotein receptor (LDLR) levels in diffuse type gastric adenocarcinoma were significantly lower than those in normal mucosa, but there was no significant difference between intestinal-type gastric adenocarcinoma and normal mucosa (27). Caveolin-1 is a scaffolding protein that binds to cholesterol and is involved in intracellular cholesterol trafficking.…”

Section: Sr-bi Expression % (N) -----------------------------------mentioning

confidence: 99%

Low scavenger receptor classï¿½B typeï¿½I expression is associated with gastric adenocarcinoma tumor aggressiveness

Wang

Yuan

et al. 2018

Oncol Lett

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Abstract. Scavenger receptor class B type I (SR-BI), a well-documented high-density lipoprotein receptor, has been implicated in the development and progression of human cancer. However, little is known regarding the expression profile and clinical value of SR-BI in gastric adenocarcinoma. In the present study immunohistochemistry analysis was performed on a well-annotated gastric adenocarcinoma tissue microarray to investigate the association between SR-BI expression and clinicopathological parameters or patient outcome. The results revealed that SR-BI expression was detected in 69% of the 84 gastric adenocarcinomas. Moreover, a significant association was observed between low SR-BI expression and poor histological grade, higher Tumor-Node-Metastasis T stage, higher N stage and diffuse type carcinoma. Low SR-BI expression was also significantly associated with a shorter overall survival time in patients with gastric adenocarcinoma, although it was not an independent prognostic factor. Overall, the results of the present study demonstrated that SR-BI was possibly involved in gastric carcinogenesis and could be used as a biomarker to predict malignancy of gastric adenocarcinoma.

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3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer

Abstract: These findings show different behavior of cholesterol metabolism in the two types of gastric carcinoma and, therefore, suggest that different therapeutic strategies should be adopted.

Cited by 38 publications

References 21 publications

Fatty Acid Synthase Hyperactivation in Human Colorectal Cancer: Relationship with Tumor Side and Sex

Fatty Acid Synthase Hyperactivation in Human Colorectal Cancer: Relationship with Tumor Side and Sex

Health Benefits and Clinical Impact of Major Nutrient, Red Yeast Rice: A Review

Low scavenger receptor classï¿½B typeï¿½I expression is associated with gastric adenocarcinoma tumor aggressiveness

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