2D MnO<sub>2</sub> nanosheets generated signal transduction with 0D carbon quantum dots: synthesis strategy, dual-mode behavior and glucose detection

Gu, Jiapei; Li, Xiangqian; Zhou, Zhan; Liu, Wanqiang; Li, Kai; Gao, Jinwei; Zhao, Ying; Wang, Qianming

doi:10.1039/c9nr03583d

Cited by 49 publications

(62 citation statements)

References 53 publications

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“…), and N-CQDs are released into the solution, leading to a decreasing FRET process in the N-CQD−MnO 2 NW system. 54 The decomposition of MnO 2 NWs resulted in the gradual increase of the FL intensity of N-CQDs with a good FL recovery percentage of 62.63% (Figure 7a). Under the 365 nm UV light, the colorless solution was gradually converted into blue luminescent light, and the color of the solution was observed to change from brown to colorless by naked eyes.…”

Section: Characterization Of the N-cqds And Mno 2 Nwsmentioning

confidence: 99%

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

Dewangan

Korram

Karbhal

et al. 2021

ACS Appl. Nano Mater.

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Nitrogen-doped carbon quantum dots (N-CQDs) were synthesized by hydrothermal treatment of citric acid and triethylamine. The fluorescence resonance energy transfer (FRET)based fluorescence "switch-off−on" of N-CQD (energy donor) in the presence of MnO 2 nanowires (energy acceptor) has been successfully applied to fabricate a fluorometric probe for detection of cholesterol (ChO), glutathione (GSH), acetylcholinesterase (AChE), and chlorpyrifos. MnO 2 nanowires (MnO 2 NWs) significantly quenched the blue fluorescent emission of N-CQDs by the phenomenon of FRET. The redox reactions of MnO 2 with H 2 O 2 and thiolated compounds resulted in the decomposition of MnO 2 nanowires (brown) to give Mn 2+ ions (colorless), which induced the fluorescence recovery of N-CQDs (turn-on). The interruption of the FRET phenomenon of N-CQD−MnO 2 NW composites by the produced H 2 O 2 from the reaction of cholesterol oxidase in the presence of cholesterol, and thiocholine from the reaction of acetylthiocholine in the presence of acetylcholinesterase, causes FL recovery of N-CQDs. The inhibition of AChE by chlorpyrifos induces FL quenching (turn-off) of N-CQD−MnO 2 NW composites. The decomposition of MnO 2 NWs into Mn 2+ in the presence of glutathione resulted in the subsequent FL recovery of N-CQDs. The sensing system shows a sensitive response to cholesterol, glutathione, and chlorpyrifos pesticide, giving LODs and LOQs of 4.89 nM, 7.52 nM, 0.01 μM and 14.83 nM, 22.80 nM, 0.03 μM, respectively. The practical applicability of the proposed probe has been verified by detecting the ChO and GSH in human plasma with satisfactory results.

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Section: Characterization Of the N-cqds And Mno 2 Nwsmentioning

confidence: 99%

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

Dewangan

Korram

Karbhal

et al. 2021

ACS Appl. Nano Mater.

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“…In addition, benefiting from the dual-model response to pH changing as well as the established analytical method, wound pH could be both predicted theoretically and estimated visually in the case of blood contamination and long-term observations. Besides applications in ions and pH sensing, CDs also show selectivity toward a wide range of biomolecules including amino acids (such as cysteine), glutathione, vitamins (such as vitamin B 12 , vitamin B 7 , ascorbic acid), − formaldehyde, glucose, DNA, and proteins, ,− which are associated with health issues and diseases. Therefore, CDs can provide valuable insights into the diagnostics and early precaution of diseases.…”

Section: Optical Applicationsmentioning

confidence: 99%

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

2020

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Carbon dots (CDs), as a new type of carbon-based nanomaterial, have attracted broad research interest for years, because of their diverse physicochemical properties and favorable attributes like good biocompatibility, unique optical properties, low cost, ecofriendliness, abundant functional groups (e.g., amino, hydroxyl, carboxyl), high stability, and electron mobility. In this Outlook, we comprehensively summarize the classification of CDs based on the analysis of their formation mechanism, micro-/nanostructure and property features, and describe their synthetic methods and optical properties including strong absorption, photoluminescence, and phosphorescence. Furthermore, the recent significant advances in diverse applications, including optical (sensor, anticounterfeiting), energy (light-emitting diodes, catalysis, photovoltaics, supercapacitors), and promising biomedicine, are systematically highlighted. Finally, we envisage the key issues to be challenged, future research directions, and perspectives to show a full picture of CDs-based materials.

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Section: Nanomaterials For Diabetes Diagnosismentioning

confidence: 99%

“…Currently, organic fluorescent small molecules, quantum dots (QDs), 2D transition metal dichalcogenides (TMDs), upconversion nanoparticles (UCNPs), Au nanoclusters (AuNCs), MOFs, covalent organic frameworks (COFs), and single-walled carbon nanotubes (SWCNTs) have been used as fluorescent sources for these nanosensors. [64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] The principle of the earliest fluorescent nanosensors is based on the specific labeling of target analytes. For example, to measure blood HbA1c concentrations, fluorescent aptamers with a high affinity and specificity for HbA1c were used (Figure 8A).…”

Section: Optical Detectionmentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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2D MnO₂ nanosheets generated signal transduction with 0D carbon quantum dots: synthesis strategy, dual-mode behavior and glucose detection

Abstract: A natural resource such as peony flower has been employed for the first time as a new carbon precursor to prepare green-emitting carbon nanodots (CDs).

Cited by 49 publications

References 53 publications

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

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2D MnO2 nanosheets generated signal transduction with 0D carbon quantum dots: synthesis strategy, dual-mode behavior and glucose detection

Abstract: A natural resource such as peony flower has been employed for the first time as a new carbon precursor to prepare green-emitting carbon nanodots (CDs).

Cited by 49 publications

References 53 publications

N-Doped Carbon Quantum Dot-MnO2 Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

N-Doped Carbon Quantum Dot-MnO2 Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

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Product

Resources

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2D MnO₂ nanosheets generated signal transduction with 0D carbon quantum dots: synthesis strategy, dual-mode behavior and glucose detection

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos

N-Doped Carbon Quantum Dot-MnO₂ Nanowire FRET Pairs: Detection of Cholesterol, Glutathione, Acetylcholinesterase, and Chlorpyrifos