“…Sodium hypochlorite (NaOCl) is a frequently used root canal irrigant used by dentists (Hulsmann & Hahn, ). Although NaOCl is capable of dissolving tissues and has potent antibacterial effect (Dube & Jain, ; da Silva, Alves, Lutterbach, Paiva, & Ferreira, ; Rocas & Siqueira, ), it has several demerits including cytotoxic effect, especially when introduced into the periapical region (Fouad, ; Hulsmann & Hahn, ; Kumar et al, ), accidental injuries to the eyes, skin, and mucous membrane (Serper, Ozbek, & Calt, ; Singh, ) and allergic reaction is also reported (Baser Can, Karapinar Kazandag, & Kaptan, ). Also, it can damage permanent tooth follicles, peripheral tissues, and oral mucosa (Nara, Dhanu, & Anandakrishna, ).…”