Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population

Guarnizo-Poma, Mirella; Urrunaga-Pastor, Diego; Montero-Suyo, Cory; Lázaro-Alcántara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Benítes-Zapata, Vicente A.

doi:10.1016/j.dsx.2018.05.022

Cited by 13 publications

(11 citation statements)

References 32 publications

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“…A study in adult population from North India showed that low B12 level was observed to be significantly associated with both low HDL and hyperhomocysteinemia, whereas after controlling for the confounder tHcy, B12 was found to be associated with all lipid indices including HDL [57]. A negative correlation was also observed between B12 levels and the prevalence of MetS in euthyroid participants [58].…”

Section: Vitamin B12 and Dyslipidemiamentioning

confidence: 99%

“…Although CKD patients demonstrate an impairment in tissue uptake of B12 resulting in functional deficiency [71], the current evidence remains unclear to consider altered B12, folate and elevated tHcy levels as markers for CVD and cardiovascular mortality risk in ESRD and CKD individuals [72]. [58] c. B12 supplementation reduced the risk of stroke in patients with CVD and/or renal disease [67].…”

Section: Vitamin B12 and Cardiovascular Diseasesmentioning

confidence: 99%

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Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies

et al. 2020

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Obesity is a worldwide epidemic responsible for 5% of global mortality. The risks of developing other key metabolic disorders like diabetes, hypertension and cardiovascular diseases (CVDs) are increased by obesity, causing a great public health concern. A series of epidemiological studies and animal models have demonstrated a relationship between the importance of vitamin B12 (B12) and various components of metabolic syndrome. High prevalence of low B12 levels has been shown in European (27%) and South Indian (32%) patients with type 2 diabetes (T2D). A longitudinal prospective study in pregnant women has shown that low B12 status could independently predict the development of T2D five years after delivery. Likewise, children born to mothers with low B12 levels may have excess fat accumulation which in turn can result in higher insulin resistance and risk of T2D and/or CVD in adulthood. However, the independent role of B12 on lipid metabolism, a key risk factor for cardiometabolic disorders, has not been explored to a larger extent. In this review, we provide evidence from pre-clinical and clinical studies on the role of low B12 status on lipid metabolism and insights on the possible epigenetic mechanisms including DNA methylation, micro-RNA and histone modifications. Although, there are only a few association studies of B12 on epigenetic mechanisms, novel approaches to understand the functional changes caused by these epigenetic markers are warranted.

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Section: Vitamin B12 and Dyslipidemiamentioning

confidence: 99%

Section: Vitamin B12 and Cardiovascular Diseasesmentioning

confidence: 99%

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies

et al. 2020

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“…As described in the literature (51,52) , the dietary intake estimated through 24 h recalls collected by phone is comparable to the dietary intake that is collected face-to-face. Although some studies have described the association between increased body adiposity and B 12 deficiency in the general population (14)(15)(16)(17)(18)(19)21) , to our knowledge, the present study is the first to register this association in KTR. We observed that B 12 deficiency was associated with increased central body adiposity (evaluated by WC) in the analysis including the whole cohort of KTR and with increased total and central body adiposity in the analysis including only women (considering both the anthropometric measures and DXA).…”

Section: Discussionmentioning

confidence: 72%

“…authors (14)(15)(16)(17)(18)(19)(20)(21) . However, to date, no study has evaluated the association of serum B 12 levels with excessive body weight using a 'gold standard' method to evaluate body adiposity such as dual-energy X-ray absorptiometry (DXA).…”

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confidence: 99%

Vitamin B12 status in kidney transplant recipients: association with dietary intake, body adiposity and immunosuppression

et al. 2019

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The aim of the present study was to evaluate the prevalence of vitamin B12 (B12) deficiency in kidney transplant recipients (KTR) and its possible association with B12 dietary intake, body adiposity and immunosuppressive drugs. In this cross-sectional study, we included 225 KTR, aged 47·50 (sd 12·11) years, and 125 (56 %) were men. Serum levels of B12 were determined by chemiluminescent microparticle intrinsic factor assay and the cut-off of 200 pg/ml was used to stratify KTR into B12-sufficient or B12-deficient group. B12 dietary intake was evaluated by three 24 h dietary recalls and was considered adequate when ≥2·4 μg/d. Body adiposity was estimated after taking anthropometric measures and using the dual-energy X-ray absorptiometry (DXA) method. B12 deficiency was seen in 14 % of the individuals. B12-deficient group, compared with the B12-sufficient group, exhibited lower intake of B12 (median 2·42 (interquartile range (IQR) 1·41–3·23) v. 3·16 (IQR 1·94–4·55) μg/d, P = 0·04) and higher values of waist circumference (median 96·0 (IQR 88·0–102·5) v. 90·0 (IQR 82·0–100·0) cm, P = 0·04). When the analysis included only women, B12 deficiency was associated with higher total and central body adiposity measurements obtained with anthropometry (BMI, body adiposity index, waist and neck circumferences) and DXA (total and trunk body fat). Among individuals with adequate intake of B12, the deficiency of this vitamin was more frequently seen in those using mycophenolate mofetil (MMF) (17 %) v. azathioprine (2 %), P = 0·01. In conclusion, the prevalence of B12 deficiency in KTR was estimated as 14 % and was associated with reduced intake of B12 as well as higher adiposity, especially in women, and with the use of MMF.

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“…In addition to CRP, some dietary food components involved as intermediates in various metabolic pathways appear altered in population with metabolic syndrome, making possible its use as biomarkers. Polyunsaturated fatty acids (PUFA), specifically eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA), are inversely related to metabolic syndrome in adults [8]; several studies have stablished an association between this syndrome and selenium blood concentration [9] or serum levels of vitamin B12 [10]; Urrunaga-Pastor et al [11] also found an association between vitamin D deficiency and hyperinsulinemia; adults with metabolic syndrome also have suboptimal concentrations of several antioxidants (retinyl esters, vitamin C, and all carotenoid concentrations, except lycopene), partly due to the lower intake of fruit and vegetables by these individuals [12]. These results reinforce the relationship between diet and the incidence of metabolic syndrome.…”

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confidence: 99%

_{Probiotics and Other Bioactive Compounds with Proven Effect against Obesity and Hypertension: Food Design Opportunities from Lulo Fruit (Solanum quitoense)}

Betoret¹,

Hinestroza²,

Seguí³

et al. 2020

Nutraceuticals - Past, Present and Future

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This book chapter aims to identify those bioactive compounds that are the most effective in obesity and hypertension prevention and/or treatment, these being the two main disorders associated with metabolic syndrome. Focusing on probiotics and phytochemicals, the document will provide evidences from both in vitro and in vivo studies as well as information about the action mechanisms and how they are affected by the interaction with other food ingredients, the food matrix in which they are placed, etc. Given its high antioxidant capacity, in part due to its spermidine content, lulo fruit has generated considerable interest among health researchers. This, together with its exotic organoleptic properties, offers interesting growth opportunities for the design of new food products from lulo fruit. This book chapter will also discuss some of them.

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Association between serum vitamin B12 levels and metabolic syndrome in a euthyroid population

Cited by 13 publications

References 32 publications

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies

Vitamin B12 status in kidney transplant recipients: association with dietary intake, body adiposity and immunosuppression

_{Probiotics and Other Bioactive Compounds with Proven Effect against Obesity and Hypertension: Food Design Opportunities from Lulo Fruit (Solanum quitoense)}

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