Vitamin B12 status in kidney transplant recipients: association with dietary intake, body adiposity and immunosuppression

Pontes, Karine Scanci da Silva; Klein, Márcia Regina Simas Torres; Costa, Mariana Silva da; Rosina, Kelli Trindade de Carvalho; Barreto, Ana Paula Menna; Silva, Maria Inês Barreto; Rioja, S

doi:10.1017/s0007114519001417

Cited by 4 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variants of this gene have been linked to low blood levels of vitamin B12, especially when following a vegetarian diet. Vitamin B12 deficiency is also associated with a diet low in meat and dairy products, total or partial resection of the stomach, resection of the ileum, the use of metformin, drugs blocking the secretion of gastric acid, and others [ 18 ]. Vitamin B12 deficiency leads to hematological and neurological symptoms, including glossitis, fatigue, macrocytic anemia, and peripheral neuropathy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Importance of the FUT2 rs602662 Polymorphism in the Risk of Cardiovascular Complications in Patients after Kidney Transplantation

Kotowski,

Ostrowski,

Sieńko

et al. 2024

IJMS

View full text Add to dashboard Cite

The FUT2 gene encodes an enzyme called α-1,2-fucosyltransferase, which is involved in the formation of blood group antigens AB0(H) and is also involved in the processes of vitamin B12 absorption and its transport between cells. FUT2 gene polymorphisms are associated with vitamin B12 levels in the body. Vitamin B12 deficiency associated with hyperhomocysteinemia is a major risk factor for cardiovascular diseases (CVDs), which are one of the main causes of death in patients after kidney transplantation. The aim of our study was to determine the impact of the rs602662 (G>A) polymorphism of the FUT2 gene on the functionality of transplanted kidneys and the risk of CVD in patients after kidney transplantation. The study included 402 patients treated with immunosuppression (183 patients taking cyclosporine (CsA) and 219 patients taking tacrolimus (TAC)). The analysis of the FUT2 rs602662 (G>A) polymorphism was performed using real-time PCR. Patients with CsA were more likely to be underweight (1.64% vs. 0.91%) and obese (27.87% vs. 15.98%), while those taking TAC were more likely to be of normal weight (39.27%) or overweight (43.84%). No statistically significant differences were observed comparing the mean blood pressure, both systolic and diastolic. The renal profile showed a higher median urea nitrogen concentration in patients with CsA (26.45 mg/dL (20.60–35.40) vs. 22.95 mg/dL (17.60–33.30), p = 0.004). The observed frequency of rs602662 alleles of the FUT2 gene was similar in the analyzed groups. The A allele was present in 43.7% of patients with CsA and 41.1% of those taking TAC (OR = 0.898; 95% CI: 0.678–1.189; p = 0.453). In the group with CsA, the GG genotype was present in 32.2% of patients, the GA in 48.1% and the AA in 19.7%. A similar distribution was obtained in the TAC group: GG—33.8%, GA—50.2%, and AA—16.0%. An association of genotypes containing the G allele with a higher incidence of hypertension was observed. The G allele was present in 65% of people with hypertension and in 56% of patients with normal blood pressure (p = 0.036). Moreover, the evaluation of the renal parameters showed no effect of the FUT2 polymorphism on the risk of organ rejection because the levels of creatinine, eGFR, potassium, and urea nitrogen were prognostic of successful transplantation. Our results suggest that the rs6022662 FUT2 polymorphism may influence the risk of cardiovascular diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Vitamin B12 deficiency leads to hematological and neurological symptoms, including glossitis, fatigue, macrocytic anemia, and peripheral neuropathy. Additionally, vitamin B12 deficiency is strongly associated with hyperhomocysteinemia, which is a major risk factor for cardiovascular diseases (CVDs) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Importance of the FUT2 rs602662 Polymorphism in the Risk of Cardiovascular Complications in Patients after Kidney Transplantation

Kotowski,

Ostrowski,

Sieńko

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…There is some understanding of the impact of immunosuppressive therapy on the nutritional status of patients within the initial year following kTx. Researchers examine various outcomes such as weight, the prevalence of diabetes, lipid abnormalities, or deficiencies in minerals and vitamins [33][34][35][36]. For example, in a cross-sectional study, vitamin B12 deficiency was linked to reduced dietary intake of B12 as well as the use of mycophenolate mofetil [33].…”

Section: Introductionmentioning

confidence: 99%

“…Researchers examine various outcomes such as weight, the prevalence of diabetes, lipid abnormalities, or deficiencies in minerals and vitamins [33][34][35][36]. For example, in a cross-sectional study, vitamin B12 deficiency was linked to reduced dietary intake of B12 as well as the use of mycophenolate mofetil [33]. However, in a clinical trial, cyclosporine was associated with increased HDL and LDL cholesterol levels at 1-month post-transplant.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive Therapy and Nutritional Status of Patients after Kidney Transplantation: A Protocol for a Systematic Review

Kajdas,

Szostak-Węgierek,

Dąbrowska-Bender

et al. 2023

JCM

View full text Add to dashboard Cite

(1) Background: Kidney transplantation is widely recognized as the most effective method of treating end-stage renal disease. Immunosuppressive therapy plays a pivotal role in the treatment of kidney transplant patients, encompassing all patients (except identical twins), and is administered from organ transplantation until the end of its function. The aim of this systematic review is to identify the evidence of the association between immunosuppressive therapy and nutritional status of patients following kidney transplantation. (2) Methods: This protocol has been designed in line with Preferred Items for Systematic Reviews (PRISMA-P). Our search encompasses several databases, including MEDLINE (via PubMed), EMBASE (Elsevier), Scopus and Web of Science. We intend to include observational studies (cross-sectional, case-control, and cohort designs), randomized controlled trials (RCTs), as well as completed and ongoing non-randomized study designs. We will confine our search to studies published in English within the past decade (from inception to 17 February 2023). Qualitative studies, case studies, and conference reports will be excluded. The selection process will be done in Covidence by two independent reviewers. Data extraction will be conducted using a standardized MS Excel template version 16.0. Quality assessment of included studies will be performed using the Cochrane Risk of Bias tool for randomized trials (RoB2), or the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. Risk-of-bias plots will be generated using the web application Robvis. Relevant data that have been extracted from eligible studies will be presented in a narrative synthesis. We expect the studies to be too heterogeneous to perform subgroup analyses. (3) Conclusion: This systematic review will offer insights into the evidence regarding association between immunosuppressive therapy and nutritional status of adult patients (18 years of age or older) within the initial year following kidney transplantation. To our knowledge, there is no systematic review addressing that question.

show abstract

Assessment and management of vitamin status in children with CKD stages 2–5, on dialysis and post-transplantation: clinical practice points from the Pediatric Renal Nutrition Taskforce

Anderson,

Tuokkola,

Qizalbash

et al. 2024

Pediatr Nephrol

View full text Add to dashboard Cite

Children with chronic kidney disease (CKD) are at risk for vitamin deficiency or excess. Vitamin status can be affected by diet, supplements, kidney function, medications, and dialysis. Little is known about vitamin requirements in CKD, leading to practice variation.The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric kidney dietitians and pediatric nephrologists, was established to develop evidence-based clinical practice points (CPPs) to address challenges and to serve as a resource for nutritional care. Questions were formulated using PICO (Patient, Intervention, Comparator, Outcomes), and literature searches undertaken to explore clinical practice from assessment to management of vitamin status in children with CKD stages 2–5, on dialysis and post-transplantation (CKD2-5D&T). The CPPs were developed and finalized using a Delphi consensus approach. We present six CPPs for vitamin management for children with CKD2-5D&T. We address assessment, intervention, and monitoring. We recommend avoiding supplementation of vitamin A and suggest water-soluble vitamin supplementation for those on dialysis. In the absence of evidence, a consistent structured approach to vitamin management that considers assessment and monitoring from dietary, physical, and biochemical viewpoints is needed. Careful consideration of the impact of accumulation, losses, comorbidities, and medications needs to be explored for the individual child and vitamin before supplementation can be considered. When supplementing, care needs to be taken not to over-prescribe. Research recommendations are suggested.

show abstract

Vitamin B12 status in kidney transplant recipients: association with dietary intake, body adiposity and immunosuppression

Cited by 4 publications

References 47 publications

The Importance of the FUT2 rs602662 Polymorphism in the Risk of Cardiovascular Complications in Patients after Kidney Transplantation

The Importance of the FUT2 rs602662 Polymorphism in the Risk of Cardiovascular Complications in Patients after Kidney Transplantation

Immunosuppressive Therapy and Nutritional Status of Patients after Kidney Transplantation: A Protocol for a Systematic Review

Assessment and management of vitamin status in children with CKD stages 2–5, on dialysis and post-transplantation: clinical practice points from the Pediatric Renal Nutrition Taskforce

Contact Info

Product

Resources

About