Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis

Abstract

Mucoadhesive membranes were proposed in this study as drug delivery system for betamethasone-17-valerate (BMV) in the treatment of recurrent aphthous stomatitis (RAS). The membranes were obtained by using the polymers chitosan (CHI) in both presence and absence of polyvinilpyrrolidone (PVP), following the solvent evaporation method. The presence of PVP in the membranes causes significant modifications in its thermal properties. Changes in the thermal events at 114 and 193 °C (related to BMV melting point), and losses in mass (39.38 and 30.68% for CH:PVP and CH:PVP-B, respectively), suggests the incorporation of BMV in these membranes. However, the morphological aspects of the membranes do not change after adding PVP and BMV. PVP causes changes in swelling ratios (>80%) of the membranes, and it is suggested that the reorganization of the polymer mesh was highlighted by the chemical interactions between the polymers leading to different percentages of BMV released ∼40% and ∼80% from CH-B and CH:PVP-B. BMV release profile follows Korsmeyer and Peppas model (n > 0.89) which suggests that the diffusion of the drug in the swollen matrix is driven by polymer relaxation. In addition, the membranes containing PVP (higher swelling ability) present high rates of tensile strength, and therefore, higher mucoadhesion. Moreover, given the results presented, the developed mucoadhesive membranes are a promising system to deliver BMV for the treatment of RAS.

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

“…In transdermal products like ointments, creams, and gels, PVP is used to develop hydrogels (that act as diffusion matrix) and as a crystal growth inhibitor in certain drug-adhesive matrix systems. Because of the excellent adhesive property shown by PVP in addition to its physiological safety and inertness, it is used as an adhesive in several mucoadhesive drug delivery systems [ 109 , 110 ] and transdermal systems [ 111 ] because of its properties like adhesiveness, crystal inhibition, solubilization, etc. Transdermal products include gels, patches, buccal tablets, meant for adhesion to the skin or mucous membrane [ [112] , [113] , [114] ].…”

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

“…The combination of polymers increase mechanical bonds between polymers and mucosa [46]. In addition, mucoadhesive ability of Ch based on the formation of hydrogen bond or ionic interaction between the positively charged amino moiety of Ch with negatively charged components of mucus including sialic acid, as well as epithelial surfaces [35,47]. The mucoadhesive polymer system plays an important role in RAS that can cover oral lesions to prevent long-term deterioration of lesions and bacterial proliferation [48].…”

“…In addition, mucoadhesive ability of Ch based on the formation of hydrogen bond or ionic interaction between the positively charged amino moiety of Ch with negatively charged components of mucus including sialic acid, as well as epithelial surfaces [34,46]. The mucoadhesive polymer system plays an important role in RAS that can cover oral lesions to prevent long-term deterioration of lesions and bacterial proliferation [47]. These results suggest that ChAlg/α-M HF was able to increase the attachment time of ChAlg HF to the mucous layer.…”

Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case

“…Many factors determine the optimum formulation of buccal delivery films, such as the mucoadhesive property of polymers, biodegradation, biocompatibility, drug release, water permeation, physiomechanical properties [18]. The selection of suitable polymers allows the modulation of properties designed for oral films [19][20][21]. The polymers that are mostly used as mucoadhesive are predominantly hydrophilic polymers that swell and allow chain interactions with the mucin molecules in the buccal mucosa [22].…”