Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees

Granata, Giuseppe; Iorio, Riccardo Di; Romanello, Roberto; Iodice, Francesco; Raspopović, Staniša; Petrini, Francesco Maria; Strauss, Ivo; Valle, Giacomo; Čvančara, Paul; Andreu, David; Divoux, Jean-Louis; Guiraud, David; Wauters, Loic; Hiairrassary, Arthur; Jensen, Winnie; Micera, Silvestro; Rossini, Paolo Maria

doi:10.1016/j.clinph.2018.02.138

Cited by 37 publications

(27 citation statements)

References 9 publications

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“…To date, the following has been concluded from neuroprosthetics research: 1) The most reliable method to extract motion intention for an upper limb from the prosthetic user is to decode the electrical activity of the muscle. [72][73][74][75][76][77][78][79][80][81][82][83][84][85][86] 2) By stimulating the peripheral nerves electrically, [79,80,87] close-to-natural sensations can be provided to the brain including pressure, object shape, stiffness, and texture. [79,80,[87][88][89][90][91][92][93][94][95][96][97][98][99][100] 3) The sensations evoked by nerve-cuff electrodes and interface nerve electrodes are stable for a duration of 24 months.…”

Section: Neuro-stimulation-based Actuatorsmentioning

confidence: 99%

Soft Actuators for Soft Robotic Applications: A Review

El‐Atab

Mishra

Al‐Modaf

et al. 2020

Advanced Intelligent Systems

323

224

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The compliant, continuum, and configurable robotics field in general has gained growing interest in the past years especially with the exciting advances in artificial intelligence technology, [1] which could enable various valuable applications ranging from manufacturing to safety and healthcare. [2,3] Soft robots are of notable interest because, unlike their rigid counterpart, they can easily deform while being mechanically resilient, [4,5] adapt to the outer environment without harm to humans, [6] and finally, enable low-cost manufacturing. [7] For robots to interact with the outer environment and complete tasks, a set of sensors and actuators need to be integrated into the system. Soft robots, in specific, present additional challenges because their sensing and actuation devices are generally highly integrated within the body of the robot and its whole functionality. These challenges become even more critical when the soft robot is scaled down to sub-centimeter size as the sensing, power, and data analysis units are moved off-board. As a result, miniaturized soft actuators that respond to various stimuli and show large deformations in addition to mechanical resilience are crucial. These would be particularly promising for application in artificial muscles, microrobots, and micro-manipulators. [8-10] Active and soft materials are promising for this task as they can be actuated through various external stimuli, such as photons, thermal, magnetic and/or electric field. Such materials range from particles, to polymers (either electroactive or shape memory), papers, fluids, shape memory alloys (SMAs), liquid metals, hydrogels, 2D materials, or a combination of these. [6-25] Nevertheless, some materials can be more suitable for a specific set of applications than others; for instance, materials stimulated by the near-infrared (NIR) spectrum are promising for biomedical applications, whereas sunlight-stimulated materials are suitable for nature-inspired soft robots used in outside environments. Various useful metrics are generally used to assess the performance of the actuators; these include the generated stress and strain, Young's modulus or measured stiffness, in addition to their power, work, energy, and force density. In this Review article, however, we focus on the application of the soft actuators in soft robotics where the reported metrics include mode and speed of actuation (or locomotion), power, voltage, current (of the driving signal), lifting force, and weight among others. In this Review article, different active materials that have been developed and used in soft actuators for soft robotics are discussed and grouped by the stimulus that generates the actuation response as shown in Figure 1. The physics of operation, resulting deformations, mechanical resilience, and their pros and cons are presented with a focus on the applications of the different soft

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Section: Neuro-stimulation-based Actuatorsmentioning

confidence: 99%

Soft Actuators for Soft Robotic Applications: A Review

El‐Atab

Mishra

Al‐Modaf

et al. 2020

Advanced Intelligent Systems

323

224

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“…For the sensation type, we adapted the questionnaire proposed by Kim et al. [21] based on our experience with several upper limb patients stimulated with invasive [2,9,[25][26][27][28][29][30][31] and non-invasive technologies [12,32]. We also considered other studies on sensations elicited using peripheral [3,29,33] or central [4] neural stimulation approaches.…”

Section: Somatosensory Questionnairesmentioning

confidence: 99%

“…During the clinical trial we collected feedback information from patients, clinicians and engineers who used the platform presented in this study in three clinical trials (N=12). The investigations regarded the development and assessment of bidirectional hand prostheses for upper limb amputees with a neural sensory feedback delivered by implantable electrodes [9,[26][27][28]31]. After six months of use, we asked participants to answer different quality and usability questions using: questionnaires for user interface satisfaction (QUIS) [37], system usability scales (SUS) [38,39], Nielsen's attributes of usability (NAU) [40] and after-scenario questionnaires (ASQ) [41].…”

Section: Quality and Usability Assessmentmentioning

confidence: 99%

A psychometric platform to collect somatosensory sensations for neuroprosthetic use

Valle

Iberite

Strauss

et al. 2020

Preprint

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Somatosensory neuroprostheses exploit invasive and non-invasive feedback technologies to restore sensorimotor functions lost to disease or trauma. These devices use electrical stimulation to communicate sensory information to the brain. A sensation characterization procedure is thus necessary to determine the appropriate stimulation parameters and to establish a clear personalized map of the sensations that can be restored. Several questionnaires have been described in the literature to collect the quality, type, location and intensity of the evoked sensations, but there is still no standard psychometric platform. Here we propose a new psychometric system containing previously validated questionnaires on evoked sensations, which can be applied to any kind of somatosensory neuroprosthesis. The platform collects stimulation parameters used to elicit sensations; records subjects’ percepts in terms of sensation location, type, quality, perceptual threshold, and intensity. It further collects data using standardized assessment questionnaires and scales, performs measurements over time, and collects phantom limb pain syndrome data. The psychometric platform is user-friendly and provides clinicians with all the information needed to assess the sensory feedback. The psychometric platform was validated with three trans-radial amputees. They platform was used to assess intraneural sensory feedback provided through implanted peripheral nerve interfaces. The proposed platform could act as a new standardized assessment toolbox to homogenize the reporting of results obtained with different technologies in the field of somatosensory neuroprosthetics.

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“…We used a computerized psychophysical testing platform to deliver stimuli and obtain the patient's response, and we statistically analyzed the results. 14 One volunteer participated in receiving "direct" peripheral sensory feedback, 15 and eight volunteer subjects participated in the noninvasive trials.…”

Section: Introduction To the Case-the Epione Research Projectmentioning

confidence: 99%

Ethical Assessment and Reflection in Research and Development of Non-Conformité Européene Marked Medical Devices

Telléus

Jensen²

2020

Camb Q Healthc Ethics

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Today there are multiple implantable medical devices on the market. The type of implants that interface the body’s tissues has been considered to have particular strong ethical implications. This article describes a development of a novel practice for ethical assessment and reflection within medical device research and development of non-CE marked medical devices, taking the perspective of both the ethicist and the researcher. The research case was an EU funded project where the aim was to develop and compare the efficiency of invasive and non-invasive technological medical devices to create meaningful sensations as a novel therapy for phantom limb pain. An Independent Ethical Advisor (IEA) with a regulatory and advisory role was assigned to the project, allowing us to investigate the projects deliberate incorporation of ethics. In the article we suggest and applied a novel framework based on action research for combining ethical assessment with building ethical reflection. The case analyse five different activities / elements: 1) the use of informed consent; 2) a survey amongst the research partners; 3) a workshop session; 4) observation of consortium meetings; and 5) an interview with a participating patient.

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Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees

Cited by 37 publications

References 9 publications

Soft Actuators for Soft Robotic Applications: A Review

Soft Actuators for Soft Robotic Applications: A Review

A psychometric platform to collect somatosensory sensations for neuroprosthetic use

Ethical Assessment and Reflection in Research and Development of Non-Conformité Européene Marked Medical Devices

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