Psychosocial Burden and Other Impacts of Rosacea on Patients’ Quality of Life

Oussedik, Elias; Bourcier, Marc; Tan, Jerry

doi:10.1016/j.det.2017.11.005

Cited by 54 publications

(48 citation statements)

References 72 publications

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“…The chronicity of rosacea along with the flares in visible areas impair the both physical and psychological sights, inflicting a negative impact on the quality of life (QoL), and as a consequence, some patients may develop stigmatization, depression, anxiety, and low self-esteem (Egeberg, Hansen, Gislason, & Thyssen, 2016;Halioua, Cribier, Frey, & Tan, 2017;Oussedik, Bourcier, & Tan, 2018;van der Linden, van Rappard, Daams, et al, 2015). Even more, rosacea patients have been linked with higher risk of mood, impulse control, and personality disorders (Singam, Rastogi, Patel, Lee, & Silverberg, 2019).…”

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confidence: 99%

Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis

Husein‐ElAhmed

Steinhoff

2020

Dermatologic Therapy

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Rosacea is a chronic dermatosis which affects negatively patients' quality of life (QoL).There is shortage of high-quality evidence comparing the efficacy of ivermectin cream (IVM) 1% with other available topical choices. Besides, the well-documented impaired of self-esteem and stigmatization of rosacea patients make essential to address which treatment provides the greatest psychological and social benefit. Our objective is to critically review and appraise the efficacy of IVM 1% in PPR and the impact in patients' QoL against other options. We carried out a literature search from PubMed, MEDLINE, EMBASE, Cochrane, and clinicaltrials.gov using the following descriptors:"rosacea" AND "ivermectin." Efficacy was assessed with the Investigator Global Assessment (IGA), and the impact on QoL was based on the DLQI score. Six studies from four published articles were included. The meta-analysis estimated that more participants achieved "success" (IGA ≤ 1) and "complete clearance" (IGA = 0) with IVM1%. The overall effect estimate for IGA ≤ 1 was: 1.56 [1.23-1.97], whereas for IGA = 0, it was: 1.72 [1.40-2.11]. The rate of participants achieving lower DLQI score, and thus, better QoL was with IVM 1%. The overall effect estimate was: 1.71 [1.34-2.18] at week 16# and 1.64 [1.38-1.94] at week 52#. This meta-analysis confirms IVM 1% cream as the most effective topical treatment and it satisfies the impairment of social life with sustained better QoL. Further studies extending this period of remission are warranted, as well as researches about the potential application of this agent combined with other agents. KEY POINTSQuestion: What is the current efficacy of ivermectin versus other choices in papulopustular rosacea and its impact on patients' quality of life?Findings: In this meta-analysis, ivermectin showed higher efficacy than metronidazol, azelaic acid, and placebo measured by Investigator Global Assessment. Parallely, the DLQI score highlighted that this agent was more beneficious in both short and long-term.Meaning: This meta-analysis gives strong evidence that ivermectin is the most effective topical treatment. Besides, this agent provides the greatest psychological benefit

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mentioning

confidence: 99%

Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis

Husein‐ElAhmed

Steinhoff

2020

Dermatologic Therapy

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“…Acne and rosacea are among the most common inflammatory skin disorders and are associated with significant psychosocial distress . Acne primarily affects adolescents and young adults, while rosacea is more common in adults aged > 30 years .…”

Section: Introductionmentioning

confidence: 99%

“…Acne and rosacea are among the most common inflammatory skin disorders and are associated with significant psychosocial distress. 1,2 Acne primarily affects adolescents and young adults, while rosacea is more common in adults aged > 30 years. 3,4 Previous studies have shown acne to be associated with impaired quality of life secondary to anxiety and depression, decreased self-esteem and increased social phobia.…”

Section: Introductionmentioning

confidence: 99%

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample

et al. 2019

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Summary Background Little is known about the mental health (MH) hospitalization among patients with acne and rosacea. Aims To determine the MH disorders and cost burden associated with acne and rosacea. Methods Data were examined from the 2002–2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions). Results A diagnosis of ≥ 1 MH disorder was much more common among all inpatients with vs. those without a diagnosis of acne (43.7% vs. 20.0%, respectively) and rosacea (35.1% vs. 20.0%, respectively). In multivariable logistic regression models controlling for sex, age, race/ethnicity and insurance status, acne (adjusted OR = 13.02; 95% CI 11.75–14.42) and rosacea (adjusted OR = 1.70; 95% CI 1.56–1.95) were associated with significantly higher odds of a primary admission for an MH disorder (13 and 8, respectively, of 15 MH disorders examined). Both acne and rosacea were associated with higher risk of mood, anxiety, impulse control and personality disorders, and with > $2 million of excess mean annual costs of hospitalization for MH disorders in the USA. Conclusion In this study, inpatients with acne or rosacea had increased odds of comorbid MH disorders. In particular, there was an increased number of hospital admissions secondary to a primary MH disorder with coexistent acne/rosacea. MH comorbidities were associated with considerable excess costs among inpatients with acne or rosacea.

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“…The condition may be aggravated by numerous triggers such as microorganisms, ultraviolet light, ethanol, nutrition, temperature extremes, psychosocial stress, and hormones . Symptoms of rosacea can lead to social stigmatization and can have a detrimental effect on the quality of life of affected patients …”

Section: Introductionmentioning

confidence: 99%

“…3 Symptoms of rosacea can lead to social stigmatization and can have a detrimental effect on the quality of life of affected patients. 4,5 Several topical therapies are available for treating rosacea 6 ; however, they are unlikely to reduce telangiectasia. 3 Intense pulsed light (IPL) devices can successfully treat the clinical manifestations of rosacea that fail to respond to medical therapies, such as telangiectases and background centrofacial erythema.…”

mentioning

confidence: 99%

Open‐label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy

Peterson¹,

Katz²

2019

J of Cosmetic Dermatology

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Background Intense pulsed light therapy (IPL) decreases facial erythema and telangiectasias associated with rosacea. Topical skin care products decrease facial erythema by the action of active ingredients and masking effects. Objectives To assess the efficacy and tolerability of combining a topical skin care regimen (TSCR) comprised of a multifunctional three‐in‐one facial cream and a mineral‐based brush‐on SPF50 powder sunscreen with a single IPL treatment for treating mild‐to‐severe facial redness associated with rosacea. Methods Twenty female subjects with Fitzpatrick skin types I‐III received TSCR monotherapy for 12 weeks. At that time, subjects received a single IPL treatment and continued TSCR for 6 additional weeks. Subjects were evaluated at Baseline and at Weeks 4, 8, 12, and 18. Results Using a 7‐point redness scale, the overall mean (SD) redness score significantly improved from 3.05 (0.97) at baseline to 2.05 (0.76) at Week 18 (P < 0.01). There was a decrease in investigator‐rated erythema from baseline (bare skin) to Week 12 (bare skin, before IPL) when TSCR was used as monotherapy which did not achieve significance (P = 0.12). Most subjects (80%) were satisfied or Very satisfied with the TSCR at Week 18. All subjects (100%) agreed that it improved their baseline skin redness and most (85%) would recommend TSCR to others. TSCR was well‐tolerated with no significant changes in skin dryness, scaling, or itching. Mild burning occurred immediately following the IPL treatment at Week 12. Conclusion TSCR in combination with a single IPL treatment produced a significant improvement in overall facial redness in patients with rosacea. Longer‐term treatment with TSCR may produce continued improvement.

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Psychosocial Burden and Other Impacts of Rosacea on Patients’ Quality of Life

Cited by 54 publications

References 72 publications

Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis

Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample

Open‐label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy

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