Open‐label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy

Peterson, Jennifer D.; Katz, Tracy M.

doi:10.1111/jocd.12952

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…A retrospective study including 31 subjects revealed that the combination of pulsed dye laser and 1.0% oxymetazoline cream reduced erythema and telangiectasias both safely and effectively [55]. An open-label study including 21 subjects assessed the efficacy and tolerability of topical skin care and sun protection combined with IPL therapy [56]. After using a topical skin care regimen (TSCR) monotherapy for 12 weeks, subjects received a single IPL light therapy, following which they continued the TSCR monotherapy for another 6 weeks.…”

Section: Laser-and Light-based Therapiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

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Section: Laser-and Light-based Therapiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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“…Previous studies in patients with rosacea and those with facial photodamage have demonstrated that a topical skin care regimen in combination with IPL results in a greater improvement in overall facial redness than IPL alone. 20,21 When the epidermal barrier is disrupted as in rosacea, there is an increase in trans-epidermal water loss with a subsequent reduction in epidermal hydration levels, triggering inflammation. 22 Appropriate skin care formulations that increase hydration levels may reduce the damage to the stratum corneum, thereby maintaining the epidermal barrier function and reducing skin irritation.…”

Section: Discussionmentioning

confidence: 99%

Integrative skincare trial of intense pulsed light followed by the phyto‐corrective mask, phyto‐corrective gel, and resveratrol BE for decreasing post‐procedure downtime and improving procedure outcomes in patients with rosacea

Barbarino¹,

Bucay²,

Cohen

et al. 2022

J of Cosmetic Dermatology

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Background Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. Intense pulsed light (IPL) is an established treatment for rosacea‐associated telangiectasia, inflammation, and erythema. This study assessed whether application of a phyto‐corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure‐related adverse effects. Methods In a prospective, open‐label, split‐face, 3‐month study, 10 subjects with moderate‐to‐severe facial rosacea underwent IPL treatment on both sides of the face. The following were applied to the right side of the face only: phyto‐corrective mask once weekly starting immediately after IPL; phyto‐corrective gel twice daily; and resveratrol antioxidant treatment at night. Both sides of the face were treated with sunscreen. Subjects were assessed on Day 1, 1 and 3 months after IPL by three, independent evaluators using the 5‐point Global Aesthetic Improvement Scale (GAIS). All subjects rated skin redness, hydration, and overall improvement on Day 1 and completed a patient satisfaction questionnaire at the 1‐ and 3‐month visits. Results Ten women were enrolled, aged 44–72 years old, with moderate (n = 6) to severe (n = 4) rosacea. IPL was effective at reducing symptoms with rosacea classified as absent in five women and mild in five at the final 3‐month visit. GAIS scores also revealed improvements on both sides of the face, but the skincare treated side showed continuous improvement over 3 months with all patients remaining at least “Improved”, whereas there appeared to be a waning effect after 1 month with IPL alone. On Day 1 after IPL, all women reported less redness, improved hydration, and improved skin appearance on the right side of the face. Patient satisfaction was consistently rated higher on the right side of the face. Conclusion Application of a phyto‐corrective mask, gel, and resveratrol antioxidant serum may complement IPL treatment for rosacea by enhancing treatment outcomes and reducing procedure‐related symptoms.

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“…Several other combinations of topical and energy‐based therapies have also shown potential in reducing symptoms associated with rosacea. In an open‐label study, the treatment effects of a skin care regimen consisting of a 3‐in‐1 facial cream and SPF 50 mineral sunscreen powder in combination with IPL were investigated [18]. Patients with rosacea applied the skin care regimen daily for 18 weeks and received a single IPL treatment at week 12.…”

Section: Discussionmentioning

confidence: 99%

Oxymetazoline and Energy‐Based Therapy in Patients with Rosacea: Evaluation of the Safety and Tolerability in an Open‐Label, Interventional Study

et al. 2020

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Background and Objectives The objectives of this study were to evaluate the safety, tolerability, and efficacy of oxymetazoline hydrochloride cream, 1% (oxymetazoline) when used as an adjunctive treatment with energy‐based therapy for patients with moderate to severe facial erythema associated with rosacea. Study Design/Materials and Methods In this Phase 4, multicenter, interventional, open‐label study, eligible patients received one of four energy‐based therapies (potassium titanyl phosphate laser, intense pulsed light therapy, pulsed‐dye laser Vbeam Perfecta, or pulsed‐dye laser Cynergy) on day 1 and day 29 and once‐daily application of oxymetazoline on days 3 through 27 and days 31 through 56. Improvement from baseline in Clinician Erythema Assessment (CEA) score, patient satisfaction measures, incidence of treatment‐emergent adverse events (TEAEs), and worsening from baseline on dermal tolerability assessments and the Clinician Telangiectasia Assessment (CTA) were assessed. Data were summarized using descriptive statistics. Results A total of 46 patients (mean age, 51.1 years; 78.3% female) enrolled in this study. Similar numbers of patients received each of the energy‐based therapies in addition to oxymetazoline. All patients demonstrated an improvement from baseline in CEA during the study with 39 of 43 evaluable patients (90.7%) demonstrating an improvement 6 hours posttreatment on day 56. Most patients were satisfied or very satisfied with treatment at the end of the study. All TEAEs were mild or moderate in severity. Some patients experienced worsening in dermal tolerability assessment symptoms (range: 4–21 patients; 8.7–45.7%). Worsening in CEA and CTA were each reported by three patients (6.5%) at any time during the study. Conclusions Treatment with oxymetazoline as adjunctive therapy with energy‐based therapy was safe, well tolerated, and reduced facial erythema in patients with moderate to severe persistent facial erythema associated with rosacea. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC

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Open‐label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy

Cited by 6 publications

References 33 publications

Rosacea Treatment: Review and Update

Rosacea Treatment: Review and Update

Integrative skincare trial of intense pulsed light followed by the phyto‐corrective mask, phyto‐corrective gel, and resveratrol BE for decreasing post‐procedure downtime and improving procedure outcomes in patients with rosacea

Oxymetazoline and Energy‐Based Therapy in Patients with Rosacea: Evaluation of the Safety and Tolerability in an Open‐Label, Interventional Study

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