This technology may be a useful, nonablative resurfacing treatment for acne scarring. Scarring, texture, and pigmentation improved significantly according to investigator-rated assessment parameters. Although patient satisfaction scores did not improve, overall improvement scores did.

Review of the literature revealed that options for minimally invasive treatment options for rejuvenation of the skin of the chest include injectable PLLA, botulinum toxin, sclerotherapy, and chemical peels, along with lasers and light therapies such as IPL, PDT, and nonablative fractionated lasers. For more dramatic results, ablative fractional lasers can be safely used, although longer healing times and potential adverse effects are to be expected. Adverse events are often due to the thinness of the dermis and epidermis and the lower concentration of pilosebaceous units. If treatments are tailored to the skin of the chest, the incidence of adverse events is lower, and patients can be safely treated.

Both agents provided effective treatment, but HS caused 2.35 times as much pain during injections and resulted in two episodes of tissue necrosis.

The role angiogenesis plays in atopic dermatitis is not well understood. The authors previously demonstrated ultrastructurally dermal microvascular angiogenesis in the IL-4-transgenic mouse model of atopic dermatitis. Here, they determine the angiogenic factors involved in dermal microvascular angiogenesis, regulatory function of inflammatory cytokines on the VEGF-A production, and microvascular permeability in this model. Computer-assisted photometric analyses for immunofluorescence-labeled CD31 demonstrated a progressive increase in blood vessel number, diameter, and percent dermal areas occupied by CD31(+) vessels as the disease evolves in transgenic mice from before disease onset through early and late skin lesions. Similar findings were documented for VEGR2(+) vessels. Quantification of skin angiogenic factor mRNAs showed progressive increase of transcripts of VEGF-A, but not VEGF-B, VEGF-C, or VEGF-D. ELISA showed a similar increase of VEGF-A in the serum and skin of transgenic mice. IL-6 and IFN-gamma stimulated VEGF-A mRNA production in the skin and in primary keratinocytes of transgenic mice. Other skin angiogenic factors that increased included Ang-1, Ang-2, GBP-1, and VE-cadherin. Microvascular leakage began in the transgenic mouse skin before disease onset and peaked in the late stage. In conclusion, IL-6 and IFN-gamma may play important roles in upregulation of VEGF-A, along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis.

CO(2) foam half-life did not vary according to sclerosant solution concentration, though room air, O(2) , and CO(2)/O(2) did. The half-life of room air foam is more than 3 times as long as that of CO(2) and 1.5 times as long as that of a mixture of CO(2) and O(2). Foam half-life for room air and O(2) are similar at low concentrations of STS but differ at higher concentrations.

Fractional deep CO(2) laser is a safe method for treating rhytides, photodamaged skin, and scars with a low incidence of adverse events.

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