Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

Hu, Xiao Fang; Zhang, Qiang; Zhang, Pan Pan; Sun, Li; Liang, Ji Chao; Morris‐Natschke, Susan L.; Chen, Yong; Lee, Kuo Hsiung̀

doi:10.1016/j.fitote.2018.02.015

Cited by 29 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetes mellitus (DM) is the most common progressive disease which is characterized as continuous hyperglycemia due to the impairment of insulin production by pancreatic β-cells and/or caused by peripheral insulin resistance [1]. Long-term hyperglycemia is associated to increasing dyslipidemia, reactive oxygen species production, and declining antioxidant status [2]. Oxidative stress is one of the main mechanisms of progression of diabetes and actively leads to cellular damage that precedes the onset of many diabetic complications [3].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

et al. 2019

View full text Add to dashboard Cite

Guava (Psidium guajava L., Myrtaceae) leaves have been used as a folk herbal tea to treat diabetes for a long time in Asia and North America. In this study, we isolated polysaccharides from guava leaves (GLP), and evaluated its antioxidant activity in vitro and anti-diabetic effects on diabetic mice induced by streptozotocin combined with high-fat diet. The results indicated that GLP exhibited good DPPH, OH, and ABTS free-radical scavenging abilities, and significantly lowered fasting blood sugar, total cholesterol, total triglycerides, glycated serum protein, creatinine, and malonaldehyde. Meanwhile, it significantly increased the total antioxidant activity and superoxide dismutase (SOD) enzyme activity in diabetic mice, as well as ameliorated the damage of liver, kidney, and pancreas. Thus, polysaccharides from guava leaves could be explored as a potential antioxidant or anti-diabetic agents for functional foods or complementary medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

et al. 2019

View full text Add to dashboard Cite

show abstract

“…franchetii (Mast.) Makino possess a variety of properties, including anti-inflammatory, antimicrobial, antitumor, and anti-diabetes [19][20][21][22][23]. The ethyl acetate fraction of P. alkekengi (PAE) inhibited lipopolysaccharide-induced pro-inflammatory mediators in BV2 cells [24] and demonstrated potent memory improvement in scopolamine-induced cognitive impairments through anti-oxidative stress [25].…”

Section: Introductionmentioning

confidence: 99%

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Sun

et al. 2020

IJMS

View full text Add to dashboard Cite

We aimed to study the effects of an ethyl acetate fraction of Physalis alkekengi (PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated β-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.

show abstract

“…12 Other than that, reports have also revealed the antihyperglycemic activity of PA. 3,13 Some studies have also reported its antidiabetic activities. 14,15 Gas chromatography-mass spectrometry analysis has identified the major compounds of PA extract to be octanoic acid, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6methyl-, n-hexadecanoic acid, 5-hydroxymethylfural, and oleic acid ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning

Lee

Kim

Irfan

et al. 2020

Journal of Medicinal Food

View full text Add to dashboard Cite

The aim of this study was to investigate the efficacy of an ethanol extract of Physalis alkekengi (PA) and its mechanistic pathway of action at the molecular level for its antiobesity properties. Four-week old male Institute of Cancer Research (ICR) mice were acclimatized for a week before starting the high-fat diet (HFD) for 2 weeks to induce obesity, followed by 8 more weeks of oral administration of 10 mg/kg orlistat and 300 mg/kg of PA extract, along with HFD. Body weights of the mice and feed and water intake were recorded weekly. After a total of 12 weeks, mice were euthanized, and blood, liver, and adipose tissues were harvested for further analysis. Administration of PA extract inhibited the progression of obesity by reducing weight gain, weight of adipose tissue, and normalizing serum triglyceride, glucose, total cholesterol, highdensity lipoprotein, low-density lipoprotein, alanine aminotransferase, and aspartate aminotransferase. PA extract prevented the progression of nonalcoholic steatohepatitis induced by HFD and prevented the enlargement of liver. Phosphorylation of adenosine monophosphate-activated protein kinase a increased while phosphorylation of acetyl-CoA carboxylase was reduced. The browning gene uncoupling protein 1 expression was also increased by PA extract treatment. Our findings revealed that the antiobesity properties of PA extract may be mediated by browning of white adipose tissue.

show abstract

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

Cited by 29 publications

References 33 publications

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning

Contact Info

Product

Resources

About