Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Luo, You; Peng, Bin; Wei, Weiqian; Tian, Xiaofei; Wu, Zhenqiang

doi:10.3390/molecules24071343

Cited by 79 publications

(53 citation statements)

References 48 publications

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“…The hydroxyl groups in polysaccharide molecules can be complexed with metal ions (such as Fe 2+ , Cu 2+ ) which are necessary for the production of hydroxyl radicals, so as to inhibit the production of hydroxyl radicals that can start lipid peroxidation or prevent them from producing lipid peroxide to decompose lipids, thus inhibiting the formation of various reactive oxygen species. In addition, polysaccharides can also improve the biological activities of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, thus playing an antioxidant role (Luo et al., 2007). Therefore, it is of great theoretical and practical significance to study the extraction, structural modification, separation and purification, structural characterization, and antioxidant activity of plant polysaccharides, and also provide a theoretical basis for its medicinal value.…”

Section: Introductionmentioning

confidence: 99%

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Huang

2020

Chem Biol Drug Des

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Polysaccharide is an important macromolecule with biological activity, and its biological activity is closely related to its structure. The extraction methods and modification methods of polysaccharides directly affect the structure of polysaccharides and then affect the biological activities of polysaccharides. In this paper, the extraction, separation, and modification of polysaccharides and their advantages and disadvantages were reviewed, and the research methods of structure characterization and antioxidant activity were discussed. This not only provides ideas for optimizing the extraction, separation, and modification methods of plant polysaccharides, but also provides the basic theoretical basis for the structural analysis and antioxidant activity research of plant polysaccharides.

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Section: Introductionmentioning

confidence: 99%

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Huang

2020

Chem Biol Drug Des

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“…Curcumin, a natural polyphenol derived from the rhizome of turmeric, and quercetin, an antioxidant derived from fruits and vegetables, have been shown to have potent FRSA and antidiabetic activity [ 52 ]. Polysaccharides from the leaves of Guava (GLP) [ 53 ], Lepidium Meyenii (MECA) [ 54 ], and Olive [ 55 ] have been evaluated for their antioxidant activity in vitro and have been found to display good FRSA.…”

Section: Resultsmentioning

confidence: 99%

Forty-One Plant Extracts Screened for Dual Antidiabetic and Antioxidant Functions: Evaluating the Types of Correlation between α-Amylase Inhibition and Free Radical Scavenging

et al. 2021

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Dysregulation of glucose homeostasis followed by chronic hyperglycemia is a hallmark of diabetes mellitus (DM), a disease spreading as a worldwide pandemic for which there is no satisfactory dietary treatment or cure. The development of glucose-controlling drugs that can prevent complications of DM, such as hyperglycemia and oxidative stress, which contribute to the impairment of the key physiological processes in the body, is of grave importance. In pursuit of this goal, this study screened 41 plant extracts for their antidiabetic and antioxidant activities by employing assays to test for α-amylase inhibition and free radical scavenging activity (FRSA) and by measuring glucose uptake in L6-GLUT4myc cells. While extracts of Rhus coriaria, Punica granatum, Olea europaea, Pelargonium spp., Stevia rebaudiana, and Petroselinum crispum demonstrated significant α-amylase inhibition, the extracts of Rhus coriaria and Pelargonium spp. also demonstrated increased FRSA, and the extract of Rhus coriaria stimulated glucose uptake. These natural extracts, which are believed to have fewer side effects because they are prepared from edible plants, interfere with the process in the small intestine that breaks down dietary carbohydrates into monosaccharide and disaccharide derivatives, and thereby suppress increases in diet-induced blood glucose; hence, they may have clinical value for type 2 diabetes management. The Pelargonium spp. and Rhus coriaria extracts demonstrated the highest antidiabetic and antioxidant activities. Both plants may offer valuable medical benefits, especially because they can be taken as dietary supplements by patients with diabetes and can serve as sources of new, natural-based antidiabetic drug candidates. The enhancement of cellular glucose uptake stimulated by Rhus coriaria extract could lead to the development of clinical applications that regulate blood glucose levels from within the circulatory system. Isolating bioactive substances from these plant extracts and testing them in diabetic mice will significantly advance the development of natural drugs that have both antidiabetic and free radical-scavenging properties, likely with lesser side effects.

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“…Cholesterol CHOL is a key blood lipid index in clinical practice, and high levels of CHOL can lead to diabetes, coronary heart disease, and atherosclerosis ( Luo et al, 2019 ). CHOL levels (3.62 mmol/L, p < 0.001) were higher in HFD mice than in LFC mice (2.24 mmol/L).…”

Section: Resultsmentioning

confidence: 99%

Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Phyllostachys praecox Bamboo Shoot as Dietary Fiber

Yang

et al. 2021

Front. Bioeng. Biotechnol.

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Bamboo shoots are a renewable and abundant biomass containing cellulose, hemicellulose, and lignin. Although many studies have explored the applications of each of these components in the preparation of biochemicals and biopolymers, few studies have evaluated the utility of these components as a dietary fiber supplement. In this study, a powder consisting of the main components of bamboo shoots (cellulose, hemicellulose, and lignin) was prepared from fresh Phyllostachys praecox shoots and characterized by scanning electron microscopy, infrared spectroscopy, and X-ray diffraction. To evaluate the potential utility of these components as a dietary fiber supplement, we conducted an experiment in which this powder was supplemented in the diet of mice for 7 weeks. The experiment included three diet groups (n = 10/group): a low-fat control diet (LFC), high-fat diet (HFD), and high-fat diet with bamboo shoot powder (HFBSP). Compared with HFD mice, the body weights of LFC and HFBSP mice were lower, indicating that the addition of bamboo shoot powder could reduce the weight gain associated with the HFD. Bamboo shoot powder supplementation could also reduce the levels of triglycerides (TG), blood glucose (GLU), total cholesterol (CHOL), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in HFD mice. The fat histology images indicated that obesity was alleviated in HFBSP mice, and the liver histology images indicated that the addition of bamboo shoot powder to the HFD could reduce the risk of fatty liver disease. The addition of bamboo shoot powder to the HFD might also improve the gut microbiota of mice. Thus, the major components of bamboo shoot powder (cellulose, hemicellulose, and lignin) could be used as beneficial natural additives in the food industry.

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Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Cited by 79 publications

References 48 publications

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Forty-One Plant Extracts Screened for Dual Antidiabetic and Antioxidant Functions: Evaluating the Types of Correlation between α-Amylase Inhibition and Free Radical Scavenging

Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Phyllostachys praecox Bamboo Shoot as Dietary Fiber

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