Sarcopenia

Keller, Karsten

doi:10.1007/s10354-018-0618-2

Cited by 66 publications

(82 citation statements)

References 139 publications

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“…One of the major pathologies underlying age-related skeletal muscle failure is insulin resistance, which alters glucose metabolism [ 3 , 4 , 21 , 118 , 130 , 164 ]. Numerous studies signify that bee products may protect against muscle wasting by correcting metabolic dysregulations in skeletal muscle via activation of some of the key nutrient sensing molecules [ 69 , 96 , 100 , 106 , 109 , 111 ].…”

Section: Discussionmentioning

confidence: 99%

“…Loss of lean body mass is a direct effect of the inflammatory and oxidative conditions that develop with aging [ 1 , 2 ]—described as inflammaging. Both inflammatory mediators and free radicals, which are highly expressed in older seniors and in patients with chronic diseases, such as type 2 diabetes mellitus, cause remarkable shrinkage of fast-twitch type II fibers promoting their transformation into the slow-twitch type I fibers [ 1 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Given its high prevalence in the general population, which ranges between 5 and 40% in western countries and increases up to 50% in advanced age, sarcopenia is considered a public health problem [ 4 , 15 ]. It causes progressive decline of functional capacity, contributes to frailty, increases the risk of falls and hospitalization in old people [ 16 , 17 ], and leads to poor outcomes in patients with COVID-19 [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Ali

Kunugi

2020

Foods

106

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The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in up to 50% of older adults is increasing worldwide due to the expansion of aging populations. It is now striking young and midlife adults as well because of sedentary lifestyle and increased intake of unhealthy food (e.g., western diet). The lockdown measures and economic turndown associated with the current outbreak of Coronavirus Disease 2019 (COVID-19) are likely to increase the prevalence of sarcopenia by promoting sedentarism and unhealthy patterns of eating. Sarcopenia has multiple detrimental effects including falls, hospitalization, disability, and institutionalization. Although a few pharmacological agents (e.g., bimagrumab, sarconeos, and exercise mimetics) are being explored in different stages of trials, not a single drug has been approved for sarcopenia treatment. Hence, research has focused on testing the effect of nutraceuticals, such as bee products, as safe treatments to prevent and/or treat sarcopenia. Royal jelly, propolis, and bee pollen are common bee products that are rich in highly potent antioxidants such as flavonoids, phenols, and amino acids. These products, in order, stimulate larval development into queen bees, promote defenses of the bee hive against microbial and environmental threats, and increase royal jelly production by nurse bees. Thanks to their versatile pharmacological activities (e.g., anti-aging, anti-inflammatory, anticarcinogenic, antimicrobial, etc.), these products have been used to treat multiple chronic conditions that predispose to muscle wasting such as hypertension, diabetes mellitus, cardiovascular disorder, and cancer, to name a few. They were also used in some evolving studies to treat sarcopenia in laboratory animals and, to a limited degree, in humans. However, a collective understanding of the effect and mechanism of action of these products in skeletal muscle is not well-developed. Therefore, this review examines the literature for possible effects of royal jelly, bee pollen, and propolis on skeletal muscle in aged experimental models, muscle cell cultures, and humans. Collectively, data from reviewed studies denote varying levels of positive effects of bee products on muscle mass, strength, and function. The likely underlying mechanisms include amelioration of inflammation and oxidative damages, promotion of metabolic regulation, enhancement of satellite stem cell responsiveness, improvement of muscular blood supply, inhibition of catabolic genes, and promotion of peripheral neuronal regeneration. This review offers suggestions for other mechanisms to be explored and provides guidance for future trials investigating the effects of bee products among people with sarcopenia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Ali

Kunugi

2020

Foods

106

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“…Sarcopenia is an extrahepatic complication related to skeletal muscle, secondary to NAFLD [ 52 , 53 ]. Moreover, sarcopenia is characterized by a loss of muscle mass, decreased cross-sectional area of muscle fibers in skeletal muscle.…”

Section: Influence Of Oxidative Stress In Nonalcoholic Fatty Livermentioning

confidence: 99%

Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

González

Huerta-Salgado

Orozco-Aguilar

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more aggressive form of the disease characterized by steatosis, inflammatory status, and varying liver degrees fibrosis. NAFLD is the most prevalent chronic liver disease worldwide. The causes of NAFLD are diverse and include genetic and environmental factors. The presence of NASH is strongly associated with cirrhosis development and hepatocellular carcinoma, two conditions that require liver transplantation. The liver alterations during NAFLD are well described. Interestingly, this pathological condition also affects other critical tissues and organs, such as skeletal muscle and even the cardiovascular, renal, and nervous systems. Oxidative stress (OS) is a harmful state present in several chronic diseases, such as NAFLD. The purpose of this review is to describe hepatic and extrahepatic dysfunctions in NAFLD. We will also review the influence of OS on the physiopathological events that affect the critical function of the liver and peripheral tissues.

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“…34 Moreover, it has been shown that physiological decline of dehydroepiandrosterone, growth hormone, and IGF -1 contributed to the development of sarcopenia. 35 The role of diet Additionally, the main problem in older people is inadequate protein intake compared with the overall protein requirements. Inadequate intakes of protein 36 and vitamin D 37 have been shown to promote sarcopenic obesity.…”

mentioning

confidence: 99%

The interplay between muscle mass decline, obesity, and type 2 diabetes

Maliszewska

Adamska-Patruno

Krętowski

2019

Polish Archives of Internal Medicine

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Of note, there is a selection of measuring tools by which muscle mass is assessed. Computed tomography (CT) scans and magnetic resonance imaging (MRI) are considered the gold standards for muscle mass evaluation. 2,3 The cutoff points for low muscle mass are not yet well defined for these measurements. Due to the limited access and high cost of the abovementioned imaging studies, the EWGSOP recommends dual-energy X-ray absorptiometry (DXA) as a reference method. 2,3 Bioelectrical impedance (BIA) methods correlate with DXA, but BIA assessments seem to be less reliable because they are also dependent on hydration status. 4 The EWGSOP2 updates its algorithm for sarcopenia case findings, diagnosis, and severity determination. The EWGSOP2 advises using the SARC-F questionnaire to identify individuals with probable sarcopenia. In the next step of the algorithm, they recommend performing grip strength and chair-stand measures to identify low muscle strength. To confirm low muscle quality or quantity, the DXA or BIA methods are advised for use in usual clinical care (FIGURE 1). EWGSOP2 provided cutoff points relevant to clinical practice (TABLE 1). The prevalence rates of sarcopenia vary significantly because of different definitions, measurement tools, and patient populations. The recently published data from

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Sarcopenia

Cited by 66 publications

References 139 publications

Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

The interplay between muscle mass decline, obesity, and type 2 diabetes

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