Evaluation of the optic nerve and scleral-choroidal-retinal layer with ultrasound elastography in glaucoma and physiological optic nerve head cupping

Özen, Özkan; Özer, Murat Atabey; Tosun, Alptekin; Özen, Serkan

doi:10.11152/mu-1116

Cited by 13 publications

(8 citation statements)

References 20 publications

(34 reference statements)

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“…Recently, in the literature, elastographic studies have been performed for ocular and periocular tissues in human eyes, and there have been reported side effects. [14][15][16]22,33 There were no changes in visual function before and after an SWE examination in the participants involved in the study. Examination-dependent clinical side effects were not observed during follow-up.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, in a living rat model, Zha et al assessed the safety and feasibility of acoustic radiation force impulse elastography at a fixed high US pressure (MI of 1.6) and reported that it could be safely applied in human eyes. Recently, in the literature, elastographic studies have been performed for ocular and periocular tissues in human eyes, and there have been reported side effects . There were no changes in visual function before and after an SWE examination in the participants involved in the study.…”

Section: Discussionmentioning

confidence: 93%

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Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Şahan

Doğan

İnal

et al. 2018

J of Ultrasound Medicine

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Objectives To investigate the optic nerve's elastic properties using shear wave and strain elastography in patients with migraine compared to healthy individuals. Methods The migraine group consisted of 30 patients (16 with visual auras and 14 without auras) who had previously had a diagnosis of migraine. These were age and sex matched with healthy participants to form the control group. The findings from shear wave and strain elastography in the groups were compared. The elastographic examination was performed with a 6–15‐MHz multifrequency linear array transducer. Results The evaluation involved 30 patients with migraine (3 male and 27 female), whose mean age ± SD was 34.63 ± 10 years, and 30 healthy participants (3 males, 27 females), whose mean age was 36.4 ± 10.5 years. In strain elasticity patterns, a statistically insignificant hardening of the optic nerve in the patients with migraine was observed (P = .052). Analysis of the shear wave elastic modulus values (9.8 ± 3.34 and 12.3 ± 5.25 kPa; P = .03) revealed that differences between the healthy participants and patients with migraine were statistically significant. The results for elasticity patterns and the shear modulus suggested that the differences between migraines with and without visual auras were insignificant (P > .05). A positive correlation was discovered between the duration of the disease and the shear modulus in the patients with migraine (r = 0.496; P < .01). Conclusions Histopathologic changes in the optic nerve may be seen in patients with migraine due to possible fibrotic changes. Elastographic techniques can be useful diagnostic tools for investigating these changes.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Şahan

Doğan

İnal

et al. 2018

J of Ultrasound Medicine

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“…Tissue elasticity can be an indicator of its physiological and pathological characteristics. Recent studies have applied elastography techniques to ocular tissues [18][19][20] and suggested that these techniques could be safely used on the human eye. There is increasing evidence that the increased ICP is involved in the visual impairment in different kinds of eye conditions [12,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…In the elastography studies of glaucoma [18,19] and multiple sclerosis [20], they found that increased optic nerve stiffness is associated with fibrosis. The SOLs are often not detected until a significant clinical symptom appears or a pronounced mass effect occurs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the biomechanical properties of the posterior eye using Shear Wave Elastography in patients with increased intracranial pressure

Xiao¹,

Huang²,

Li³

et al. 2021

Med Ultrason

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Aims: This study aims to investigate the biomechanical properties of the posterior eye using the shear wave elastography (SWE) in increased intracranial pressure (ICP) patients and healthy subjects. Material and methods:This study enrolled 54 healthy subjects and 54 patients with increased ICP, including 29 patients with space-occupying lesions (SOLs) and 25 patients with intracranial haemorrhage (ICH). Optic nerve sheath diameter and the stiffness of the optic nerve head, peripapil-lary sclera and optic nerve were evaluated. Results:Patients with increased ICP had a significantly higher optic nerve sheath diameter, Young’s modulus of optic nerve head, and Young’s modulus of peripapillary sclera than healthy subjects (p<0.01 for all). The optic nerve sheath diameter, Young’s modulus of optic nerve head and Young’s modulus of the peripapillary sclera were similar between the SOLs group and ICH group (p>0.05 for all). Young’s modulus of the optic nerve in the ICH group was similar to the control group (p>0.05), whereas the SOLs group had higher Young’s modulus of optic nerve comparing the control group (p<0.05). Conclusion: The stiffness of the optic nerve head and peripapillary sclera were higher in patients with increased ICP than healthy subjects, and the optic nerve stiffness of SOLs patients was the highest in all subjects. The SWE could provide a quantitative analysis of the posterior eye’s biomechanical properties and help the clinic diagnose the degree of visual impairments.

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“…Recently, elastographic studies have been performed for ocular and periocular tissues in the human eyes, and reported some side effects (7,12,(33)(34) . The ocular tissues are particularly vulnerable to mechanical and thermal injury associated with excessive US energy, so the United States Food and Drug Administration (FDA) and World Federation for Ultrasound in Medicine and Biology have imposed strict thermal index (TI) and mechanical index (MI) limits for diagnostic ocular US applications (TI <1.0 and MI <0.23) (35)(36) .…”

Section: Discussionmentioning

confidence: 99%

Shear wave elastography in optic neuritis: diagnostic accuracy of the optic nerve and adjacent fat tissue values

Aybar¹,

Turna

2021

J Ultrason

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Introduction: In this study, we attempt to determine the diagnostic performance of shear wave elastography of the optic nerve and adjacent fat tissue in patients with optic neuritis. Methods: The study included a patient group consisting of 72 eyes of 36 patients who were diagnosed with unilateral optic neuritis, and an age-matched control group of 36 eyes of 18 healthy subjects. The patient group consisted of 25 multiple sclerosis patients and 11 recurrent isolated optic neuritis patients. The mean shear wave elastography values of the optic nerves and intraorbital fat tissue adjacent optic nerves were recorded using m/s and kPa as units. ROC curve analysis was performed, and the diagnostic accuracy of shear wave elastography values was determined. Results: The mean shear wave elastography values of the optic nerves with neuritis (2.49 ± 0.41 m/s and 17.56 ± 4.42 kPa) were significantly higher than the values of the contralateral normal optic nerves (1.71 ± 0.32 m/s and 9.02 ± 2.34 kPa) (p = 0.006 and p = 0.004, respectively) in the optic neuritis group. The mean shear wave elastography values of intraorbital fat tissue adjacent optic nerves with neuritis (1.87 ± 0.32 m/s and 9.65 ± 1.12 kPa) were significantly higher than the values of the contralateral normal side (1.47 ± 0.27 m/s and 6.78 ± 1.14 kPa) (p = 0.025 and p = 0.022, respectively) in the optic neuritis group. ROC curve analysis showed a high diagnostic accuracy for determining optic neuritis with shear wave elastography values of the optic nerves (AUC 0.955 [95% CI, 0.933–0.978] in m/s and AUC 0.967 [95% CI, 0.940–0.985] in kPa). Conclusions: Shear wave elastography may be an important alternative diagnostic tool in the diagnosis of optic neuritis.

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Evaluation of the optic nerve and scleral-choroidal-retinal layer with ultrasound elastography in glaucoma and physiological optic nerve head cupping

Cited by 13 publications

References 20 publications

Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Evaluation of the biomechanical properties of the posterior eye using Shear Wave Elastography in patients with increased intracranial pressure

Shear wave elastography in optic neuritis: diagnostic accuracy of the optic nerve and adjacent fat tissue values

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