Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review

Rodrigo, Juan P.; Grilli, Gianpaolo; Shah, Jatin P.; Medina, Jesús E.; Robbins, K. Thomas; Takes, Robert P.; Hamoir, Marc; Kowalski, Luiz Paulo; Suárez, Carlos; López, Fernando; Quer, Miquel; Boedeker, Carsten C.; Bree, Remco de; Çoşkun, Hakan; Rinaldo, Alessandra; Silver, Carl E.; Ferlito, Alfio

doi:10.1016/j.ejso.2018.01.003

Cited by 48 publications

(28 citation statements)

References 49 publications

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“…Advances in head and neck surgery have led from radical neck dissection to selective neck dissection in selected patients with squamous cell carcinoma of the oral cavity, pharynx and larynx [36]. In radiation oncology modern techniques such as IMRT or VMAT combined with image-guidance allow a higher precision in dose application and therefore individualized treatment approaches should be investigated [37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial

Haderlein

Speer

Ott

et al. 2020

Cancers

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Aim: Evaluating radiotherapy treatment plans of the prospective DIREKHT trial (ClinicalTrials.gov, NCT02528955) investigating de-intensification of radiotherapy in patients with head and neck cancer. Patients and Methods: The first 30 patients from the DIREKHT trial of the leading study centre were included in this analysis. Standard treatment plans and study treatment plans derived from the protocol were calculated for each patient. Sizes of planning target volumes (PTVs) and mean doses to organs at risk were compared using the Student’s t-test with paired samples. Results: Mean PTV3 including primary tumor region and ipsilateral elective neck up to a dose of 50 Gy in the study treatment plans was 662 mL (+/− 165 mL standard deviation (SD)) and therefore significantly smaller than those of the standard treatment plans (1166 mL (+/− 266 mL SD). In the medial and inferior constrictor muscles, cricopharyngeal muscle, glottic and supraglottic laryngeal areas, arytenoid cartilages, contralateral major salivary glands highly significant dose reductions (p < 0.0001) of more than 10 Gy were achieved in study treatment plan compared to standard treatment plan. Conclusion: De-intensification of radiotherapy led to smaller planning target volumes and clinical relevant dose reductions in the swallowing apparatus and in the contralateral salivary glands.

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Section: Discussionmentioning

confidence: 99%

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial

Haderlein

Speer

Ott

et al. 2020

Cancers

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“…In recent years ,the multidisciplinary sequential therapy strategy (including surgery, radiotherapy, chemotherapy, and biotherapy) has been used to treat OSCC, however, there has been no signi cant improvement in the 5year survival rate of patients, especially in those with neck metastasis or at an advanced pathological stage. [2][3][4] STAB2 (Special AT-rich sequence-bind 2) is a nuclear transcription factor that play a vital role in various biological functions, such as osteoblast differentiation and bone matrix formation. [5][6].…”

Section: Introductionmentioning

confidence: 99%

SATB2 Overexpression Promotes the Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma by Up-Regulating NOX4

Gao

Meng

et al. 2020

Preprint

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Background: While atypical expression of special AT-rich sequence-binding protein 2 (SATB2) has been approved associated with tumor progression, metastasis and unfavourable prognosis in various carcinomas. However, in oral squamous cell carcinoma (OSCC), both the expressive state and associated functions of SATB2’s are still undefined.Methods: Real-time PCR, western blotting, and immunohistochemistry were used to examine SATB2 expression. In vitro experiments including Flow Cytometry, CCK8 assay, migration assay, wound-healing assay were used to investigate the effects of SATB2 on HN4 cell proliferation, migration and invasion ability. Additionally, an orthotopic implantation assay was performed in nude mice to confirm the effects of SATB2 in vivo. Furthermore, a genome wide siRNA knockdown experiment was performed to explore the potential downstream regulatory mechanism of SATB2 in OSCC.Results: We found that , in clinical samples from a retrospective cohort of 58 OSCC patients, high expression of SATB2 is associated with poor prognosis of OSCC patients. In this study, we investigated SATB2 is highly expressed in OSCC tissues and cell lines ,which can promotes OSCC cells’ proliferation, migration, invasion and tumor growth. Following a genome wide siRNA knockdown experiment, we identified NOX4, a bona fide downstream target of SATB2, which can partially suppress OSCC proliferation. Furthermore, NOX4 knockdown inhibits tumorigenicity, which can be rescued partially by ectopic expression of SATB2.Conclusion: Our findings not only indicate overexpression of SATB2 triggers the proliferative, migratory and invasive mechanisms which are important in the malignant phenotype of OSCC, but also identify NOX4 as the downstream gene for SATB2. These findings indicate that SATB2 may play a key role in OSCC tumorigenicity and may be a future target for the development of new therapeutic regimens.

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“…[4,5] Discussion of the volume of cervical dissection is reflected in many publications, which proves the urgency of the problem. [6] Ultrasound-guided fine needle aspiration biopsy is a standard for the study of the metastatic status of lymph nodes. [7] However, the organ-preserving trend in oncology requires the search for new methods of diagnosing metastatic lymph nodes to accurately select the volume of intervention.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Сytoceratine 19 Expression Level By Immunocytochemical Diagnostic Method in Laryngeal Cancer Patients With Regional Metastases

2020

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The aim: To investigate the informative content of immunocytochemical studies of lymph node aspirate using a molecular marker of cytokeratin 19 in patients with laryngeal cancer as for regional metastastatic spread. Materials and methods: A comprehensive investigation with immunohistochemical study of squamous cell carcinoma of larynx of 74 patients with laryngeal cancer II – IV stage (T2-4 N0-3 M0) of the second clinical group was conducted. Results: Statistically significant differences (p <0.001) in the structure of distribution of marker expression between groups were revealed. Thus, a marked expression of cytokeratin 19 was determined in 11 (29.73%) representatives of the group with regional metastases and only in 1 (2.7%) patient without tumor metastases (p = 0.002). In the group with metastases the presence of atypical cells was confirmed cytologically in 26 cases (70,27%). Conclusions: To predict the development of laryngeal metastases in laryngeal cancer patients, it is recommended to carry out an immunocytochemical study using a diagnostic marker of cytokeratin 19. The positive status of cytokeratin 19 increases the chances of regional metastasis of laryngeal cancer by 18.37 times (p<0.001) compared with absence of expression.

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Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review

Cited by 48 publications

References 49 publications

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial

SATB2 Overexpression Promotes the Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma by Up-Regulating NOX4

Analysis of Сytoceratine 19 Expression Level By Immunocytochemical Diagnostic Method in Laryngeal Cancer Patients With Regional Metastases

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