Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics

Kim, Sung Bong; Zhang, Yi; Won, Sang Min; Bandodkar, Amay J.; Sekine, Yurina; Xue, Yeguang; Koo, Jahyun; Harshman, Sean W.; Martin, Jennifer A.; Park, Jeong Min; Ray, Tyler R.; Crawford, Kaitlyn E.; Lee, Kyu‐Tae; Choi, Jungil; Pitsch, Rhonda L.; Grigsby, Claude C.; Strang, Adam J.; Chen, Yu Yu; Xu, Shuai; Kim, Jeonghyun; Koh, Ahyeon; Ha, Jeong Sook; Huang, Yonggang; Kim, Seung Wook; Li, Jinghua

doi:10.1002/smll.201703334

Cited by 135 publications

(84 citation statements)

References 49 publications

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“…The skin-mountable microfluidic device utilizes perspiration pressure to pump sweat into soft microfluidic networks where chemical analysis can be performed via colorimetric analysis. Additionally, designs of microfluidics with capillary bursting valves advances time-dependent sweat analysis monitoring of biomarkers and secretory fluidic local pressure (Choi et al, 2017a , b ; Kim et al, 2018 ). Further, Choi et al advanced microfluidic devices by improving sequential analysis (~8.5–18 min) while evaluating volumetric precision or local perspiration pressure (Choi et al, 2017a , b ), in features of chrono-sampling of sweat, where newly generated sweat can be analyzed over time.…”

Section: Advanced Wearable Biosensorsmentioning

confidence: 99%

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Brown¹,

Ashley²,

Koh³

2018

Front. Bioeng. Biotechnol.

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152

144

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Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status. A wound monitoring device would help decrease prolonged hospitalization, multiple doctors' visits, and the expensive lab testing associated with the diagnosis and treatment of chronic wounds. A device capable of monitoring the wound status and stimulating the healing process is highly desirable. In this review, we discuss the impaired physiological states of chronic wounds and explain the current treatment methods. Specifically, we focus on improvements in materials, platforms, fabrication methods for wearable devices, and quantitative analysis of various biomarkers vital to wound healing progress.

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Section: Advanced Wearable Biosensorsmentioning

confidence: 99%

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Brown¹,

Ashley²,

Koh³

2018

Front. Bioeng. Biotechnol.

Self Cite

152

144

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“…184 The sweat is captured and routed to the micro-channels and spatially separated regions for multi-parametric sensing of markers of interest. [189][190][191][192][193][194][195][196][197] Glucose The wide spread diabetes and their need for long-term and accurate glycemic control make the glucose monitoring technologies, especially the non-invasive ones, most desirable and attractive, thus various schemes have been investigated, including optical and electrochemical ones. 198 Among them, wearable electrochemical glucose biosensors are most concerned.…”

Section: Sweatmentioning

confidence: 99%

Flexible inorganic bioelectronics

Chen¹,

et al. 2020

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Flexible inorganic bioelectronics represent a newly emerging and rapid developing research area. With its great power in enhancing the acquisition, management and utilization of health information, it is expected that these flexible and stretchable devices could underlie the new solutions to human health problems. Recent advances in this area including materials, devices, integrated systems and their biomedical applications indicate that through conformal and seamless contact with human body, the measurement becomes continuous and convenient with yields of higher quality data. This review covers recent progresses in flexible inorganic bio-electronics for human physiological parameters' monitoring in a wearable and continuous way. Strategies including materials, structures and device design are introduced with highlights toward the ability to solve remaining challenges in the measurement process. Advances in measuring bioelectrical signals, i.e., the electrophysiological signals (including EEG, ECoG, ECG, and EMG), biophysical signals (including body temperature, strain, pressure, and acoustic signals) and biochemical signals (including sweat, glucose, and interstitial fluid) have been summarized. In the end, given the application property of this topic, the future research directions are outlooked.

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“…In the case of lactate, the LIGlactate sensor performs well within the lower physiologicalrelevant range. At the same time, materials other than gauze should be investigated in the future such as specialized polymer sponges, hydrophobic fibers, or microfluidic channels [41][42][43][44][45][46].…”

Section: Amperometric Glucose and Lactate Biosensorsmentioning

confidence: 99%

Electrochemical multi-analyte point-of-care perspiration sensors using on-chip three-dimensional graphene electrodes

et al. 2020

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Multi-analyte sensing using exclusively laser-induced graphene (LIG)-based planar electrode systems was developed for sweat analysis. LIG provides 3D structures of graphene, can be manufactured easier than any other carbon electrode also on large scale, and in form of electrodes: hence, it is predestinated for affordable, wearable point-of-care sensors. Here, it is demonstrated that LIG facilitates all three electrochemical sensing strategies (voltammetry, potentiometry, impedance) in a multi-analyte system for sweat analysis. A potentiometric potassium-ion-selective electrode in combination with an electrodeposited Ag/AgCl reference electrode (RE) enabled the detection of potassium ions in the entire physiologically relevant range (1 to 500 mM) with a fast response time, unaffected by the presence of main interfering ions and sweat-collecting materials. A kidney-shaped interdigitated LIG electrode enabled the determination of the overall electrolyte concentration by electrochemical impedance spectroscopy at a fixed frequency. Enzyme-based strategies with amperometric detection share a common RE and were realized with Prussian blue as electron mediator and biocompatible chitosan for enzyme immobilization and protection of the electrode. Using glucose and lactate oxidases, lower limits of detection of 13.7 ± 0.5 μM for glucose and 28 ± 3 μM for lactate were obtained, respectively. The sensor showed a good performance at different pH, with sweat-collecting tissues, on a model skin system and furthermore in synthetic sweat as well as in artificial tear fluid. Response time for each analytical cycle totals 75 s, and hence allows a quasi-continuous and simultaneous monitoring of all analytes. This multi-analyte all-LIG system is therefore a practical, versatile, and most simple strategy for point-of-care applications and has the potential to outcompete standard screen-printed electrodes.

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Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics

Cited by 135 publications

References 49 publications

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Flexible inorganic bioelectronics

Electrochemical multi-analyte point-of-care perspiration sensors using on-chip three-dimensional graphene electrodes

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