Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Brown, Matthew S.; Ashley, Brandon K.; Koh, Ahyeon

doi:10.3389/fbioe.2018.00047

Cited by 152 publications

(149 citation statements)

References 205 publications

(342 reference statements)

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“…Hypothetically, combining the use of markers such as IL-1β with analyses of MMPs and bacterial antigens could yield higher diagnostic sensitivity and specificity with respect to wound status, enabling a simultaneous determination of bacteria, host proteolytic activities, as well as selected cytokines. Indeed, ongoing research on biosensors which can be incorporated into dressings could make future integration of such capabilities in clinical use possible (35). The levels of biomarkers such as the cytokines determined here were therefore calculated relative to the surface area as well as total protein content, and thus of high relevance for development of sensors measuring total biomarker load or concentration, respectively.…”

Section: Discussionmentioning

confidence: 99%

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

et al. 2019

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Background: A surgical site infection (SSI) is believed to be the result of an exaggerated inflammatory response. Objective: Examine the relationship between clinical status and inflammation biomarkers in full-thickness skin grafting wounds. Methods: Twenty patients planned for facial full-thickness skin grafting were enrolled. A week after surgery, all graft wounds were clinically assessed using a 3-step scale for inflammation (low, moderate, high). All wounds were swabbed for routine microbiological analysis and assessment of numbers of aerobic bacteria. Tie-over dressings from all patients were collected and used for wound fluid extraction and subsequent analysis of MMPs, cytokines, and NF-κB inducing activity. Results: Wounds with a high degree of inflammation contained increased total MMP activity ( P ≤ 0.05) in their corresponding fluids. Likewise, the level of the cytokines IL-1ß, IL-8, IL-6, TNF-α was analyzed, and particularly IL-1ß was discriminatory for highly inflamed wounds ( P ≤ 0.01). Moreover, bacterial loads were increased in highly inflamed wounds compared to wounds with a low degree of inflammation ( P ≤ 0.01). NF-κB activation in the monocytic cell line THP-1 was significantly higher when these cells were stimulated by wound fluids with a high degree of inflammation ( P ≤ 0.01). Growth of S. aureus in wounds did not vary between wounds with different degrees of inflammation (chi-square 3.8, P = 0.144). Conclusion: Biomarkers analyzed from tie-over dressings correlated to clinical wound healing in full-thickness skin grafting.

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Section: Discussionmentioning

confidence: 99%

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

et al. 2019

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“…Therefore, wound care domain required such wound monitoring system that may also consider wound internal and external factors for wounds assessment, rather than just wound appearance. In health care domain there are many applications which designed to monitor different diseases but wound care domain still required such techniques and sensing system which can identify different factors of wound area including temperature, blood pressure, oxygen and infection status of wound using biosensor [11]. In healthcare domain researchers proposed a lot of wearable devices for health centric task i.e.…”

Section: Introductionmentioning

confidence: 99%

An IoT-Based Intelligent Wound Monitoring System

et al. 2019

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Clinical research of wound assessment focused on physical appearance of wound i.e. wound width, shape, color etc. Although, wound appearance is most crucial factors to influence healing process. however, apart from wound appearance other factors also contribute in healing process. Wound internal and external environment is one such factor that may show positive or negative impact on healing. Internet of things extensively popular during last decade, due to its heavy applications in almost all domains i.e. agriculture, health, marketing, banking, home etc. Therefore, in current research we proposed IoT based intelligent wound assessment system, for assessment of wound status and apply entropy and information gain statistics of decision tree to reflect status of wound assessment by categorization of assessment results in one of three class i.e. good, satisfactory or alarming. We implemented decision tree in MATLAB, in which we select ID3 algorithm for decision tree which based on entropy and information gain for the selection of best feature to split the tree. The efficient feature split of decision tree improved training accuracy rate and performance of decision tree.

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“…2 VA, VB, VC, and VD will ensure that there is no risk of the dressing adhering to the wound surface as seen with traditional cotton gauze dressings. This is especially critical in excess wound drainage, where wound redressing can cause tissue injury thus slowing down the wound healing process [21]. The deposition of the hydrogels loaded on the fibers can be clearly seen as a dense white opacity within the fibers (Fig.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

Ilomuanya

Okafor

Amajuoyi

et al. 2020

Beni-Suef Univ J Basic Appl Sci

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Background: In this study, the chronic wound healing ability of PLA-based electrospun nanofibers loaded with hyaluronic acid, valsartan, and ascorbic acid is explored. PLA-based scaffolds were fabricated by electrospinning, followed by loading the scaffolds with different concentrations of hyaluronic acid, valsartan, and ascorbic acid hydrogels. The produced formulations were characterized by scanning electron microscopy imaging (SEM), tensile strength testing, Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). An in vitro drug release study was conducted to monitor the release of valsartan from the different formulations. This was followed by exploring the wound healing effects of the scaffolds in alloxan-induced diabetic rats and comparing the wound healing effects with positive and negative controls. Results: The average diameter of the fibers was in the range of 300 to 490 nm with high porosity in the range of 63.90 to 79.44%, offering a large surface area-to-volume ratio, enhanced drug solubility, oxygen permeability, and fluid uptake. The presence of valsartan significantly impacted on the re-epithelization rate. Percentage reepithelization rate was 31.2% ± 1.77% in the absence of treatment. Histologic section of tissue showed skin with underlying loose fibro-collagenous stroma (dermis) containing sebaceous glands and hair follicles for animals treated with VA, VB, VC, and VD. All the scaffolds reduced the number of inflammatory cell infiltrates at the wound site compared to the no treatment and conventionally treated groups. Conventional antibiotic treatment and VD (electrospun biomimetic scaffolds containing ascorbic acid) had % re-epithelization rates of 59.45% ± 1.69% and 62.01% ± 1.68% which were significantly lower than the PLA/HA-valsartan hydrogel scaffolds with VB having the highest % re-epithelization rate of 85.5% ± 1.7% (Figure 4B & 5C). Conclusion: This study explored the use of biomimetic polylactic acid-based electrospun fiber and HA-valsartan hydrogel scaffold incorporating topical angiotensin receptor blockers to successfully accelerate wound healing. The novel PLA-based electrospun fibers loaded with hyaluronic acid-valsartan hydrogels were stable and possessed proven diabetic wound healing property. This was as a result of the known biomimetic effect of the fibers and increased re-epithelization facilitated by the hydrogels containing valsartan.

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Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Cited by 152 publications

References 205 publications

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

An IoT-Based Intelligent Wound Monitoring System

Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

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