2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke

Furie, Karen L.; Jayaraman, Mahesh

doi:10.1161/strokeaha.118.020176

Cited by 95 publications

(78 citation statements)

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“…Using thrombolytic, antithrombotic and anti-aggregation agents, the blood flow of the compromised region can be restored. However, only one drug, IV Alteplase, is recommended to treat ischemic stroke, and the drug has a very short therapeutic time window and a high risk of hemorrhagic transformation, which severely limits its clinical use (6). The second therapeutic strategy, neuroprotection, aims at preventing neuronal death by regulating multiple intra-or extracellular signals that lead to cell injury.…”

Section: Introductionmentioning

confidence: 99%

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Liu

Zhang

et al. 2018

Int J Mol Med

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Section: Introductionmentioning

confidence: 99%

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Liu

Zhang

et al. 2018

Int J Mol Med

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“…Thrombolysis is one of the most effective treatments available for rescue of the penumbra of early ischemic stroke 46 but comes at the expense of increased risks of ischemia‐reperfusion injury and hemorrhage 47,48 . Eleven RCTs investigated the add‐on neuroprotective effect of Chinese herbal medicine that activates blood and resolves stasis in patients with ischemic stroke treated by thrombolysis 49‐60 .…”

Section: Recommendationsmentioning

confidence: 99%

Evidence‐based practice guideline on integrative medicine for stroke 2019

Lin

Li³

et al. 2020

J Evidence Based Medicine

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Objective: Stroke is the leading cause of death and disability in China. Chinese medicine integrated with conventional medicine is now widely used in the prevention and treatment of stroke. A clinical practice guideline for the application of integrative medicine in stroke is urgently needed.Methods: This guideline was developed following the methodology and procedures recommended in the World Health Organization Handbook for Guideline Development and the Guideline Development Handbook for Diagnosis and Therapy of Integrative Medicine. The quality of evidence and strength of recommendations were evaluated using the GRADE approach. The guideline followed the RIGHT statement and AGREE II was consulted to ensure its quality. Results:A multidisciplinary working team was established. Eleven research questions from 15 clinical questions were identified by questionnaire surveys, face-to-face meetings, and analyzed by the working team. Fourteen recommendations regarding integrative medicine for ischemic stroke, hemorrhagic stroke, and complications of stroke were formulated from systematic reviews of the benefits, harms, cost-effectiveness, quality of evidence, the values and preferences of patients and their family members, feedback on proposed recommendations from medical practitioners from a variety of disciplines, and a face-to-face consensus meeting.

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“…(2) hospitalized with a primary diagnosis of ischemic stroke, with the diagnosis being made according to the Guidelines for the Early Management of Patients with Acute Ischemic Stroke, (9) and with CT or MRI confirmation; (3) finished the face-to-face follow-up 3 months after hospital discharge; (4) gave, or authorized a representative to give informed consent. After excluding patients with incomplete follow-up information, the patients were divided into a control group (May 1, 2017-April 30, 2018) and intervention group (May 1, 2018-March 31, 2019) according to the induction of the stroke health manager.…”

Section: Study Design and Participantsmentioning

confidence: 99%