Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

Beer, Jacob; Snitz, Beth E.; Chang, Chung Chou H.; Loewenstein, David; Ganguli, Mary

doi:10.1017/s1041610217002666

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Risk of bias for selective outcome reporting was low in all studies except for one, which was deemed to have a “high” risk of bias (Fleisher et al, 2007). Finally, 10 studies were found to have an “unclear” risk of bias for blinding (Ahmed, Mitchell, Arnold, Nestor, & Hodges, 2008; Alegret et al, 2014; Beer, Snitz, Chang, Loewenstein, & Ganguli, 2018; Gallucci et al, 2018; Lekeu et al, 2010; Lonie et al, 2010; Mitchell et al, 2009; Pozueta et al, 2011; Silva et al, 2013; Yoon, Kim, Moon, Yong, & Hong, 2015), with six denoted as a “high” risk of bias for blinding (Amieva et al, 2004; Bowen et al, 1997; Devanand et al, 1997; Fleisher et al, 2007; García-Herranz et al, 2016; Lee et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Performance on neuropsychological assessment and progression to dementia: A meta-analysis.

Prado¹,

Watt²,

Treeby³

et al. 2019

Psychology and Aging

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This meta-analysis examined how performance on various cognitive domains of neuropsychological functioning can contribute to predicting progression to dementia from mild cognitive impairment (MCI) or subjective memory complaints. Studies performed between the years of 1997 and 2018 were identified through a search of the electronic databases Medline and PsycINFO. Data from the articles identified were pooled to determine standardized mean differences, calculated as Hedges g, using a random-effects model. Twenty-four studies were included in the analysis. The majority of studies examined the progression of amnestic mild cognitive impairment (aMCI) to Alzheimer’s disease (AD). Nonprogressors performed significantly better than did progressors in the domains of divided attention, executive function, expressive language, immediate recall, processing speed, delayed recall, visuospatial/constructional ability, working memory, and sustained attention. These findings indicate that individuals with MCI or subjective memory complaints who do not progress to dementia, perform better at baseline as compared with individuals that progress to dementia on a range of neuropsychological measures, and lends further support to the contention that neuropsychological assessment can make important contributions to predicting progression to dementia while individuals are still in the MCI or subjective memory complaint stage.

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Section: Resultsmentioning

confidence: 99%

Performance on neuropsychological assessment and progression to dementia: A meta-analysis.

Prado¹,

Watt²,

Treeby³

et al. 2019

Psychology and Aging

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show abstract

“…Finally, on the theme of predicting progression from MCI to dementia, Beer et al . (2018) recruited participants aged over 65 years from a clinical ( N = 184) and population-based ( N = 435) sample, all of whom had a confirmed diagnosis of MCI. They all underwent three trials of the Semantic Interference Test (SIT), which is described as a “cognitive stress test” that identifies very subtle deficits in early Alzheimer's disease (Loewenstein et al , 2004).…”

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confidence: 99%

Improving the diagnosis and prediction of progression in mild cognitive impairment

Mukadam

2018

Int. Psychogeriatr.

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Mild cognitive impairment (MCI) is a clinical condition conceptualized as a stage between normal cognition and dementia. To diagnose it requires subjective cognitive impairment, evidence of cognitive impairment on cognitive testing but no abnormality in a person's functioning and no evidence of dementia (American Psychiatric Association, 2013). There has been growing interest in the condition over the past two decades or so because people with MCI are much more likely than people with no cognitive impairment to progress to dementia (Roberts et al., 2013). However, a significant percentage of people with MCI will not progress to dementia and some will revert to having normal cognition. Rates of progression and reversion to normal cognition vary widely in different studies (Manly et al., 2008). People with MCI experience worry about their symptoms and this is partly alleviated by receiving a diagnosis of MCI and being reassured they do not have dementia (Gomersall et al., 2017). The benefits of diagnosis also include gaining a greater understanding of their symptoms and accessing clinical support but a significant amount of uncertainty remains with regards to the risk of progression and recipients of the diagnosis remain frustrated at the lack of treatments for MCI (Gomersall et al., 2017). There has been much interest in improving the prediction of progression to dementia from MCI but to date, the best predictors of progression remain structured clinical and functional assessments, with some additional benefit from measures of cortical volume/thickness from brain imaging (Korolev et al., 2016). As yet, however, there are no interventions that can prevent (Kane et al., 2017) or treat (Cooper et al., 2013) MCI so it seems set to remain an important clinical entity for the foreseeable future.

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“…The paper of Beer et al (2018) assumes that semantic interference, conceptualized as a "cognitive stress test," can be a sensitive indicator of the onset of dementia. The authors study a new instrument, Semantic Interference Test (SIT), the result of an adaptation of a pre-existing instrument, which taps proactive and retroactive semantic interference, for predicting progression from MCI to dementia.…”

mentioning

confidence: 99%

Mild cognitive impairment: some steps forward

Mateos

2018

Int. Psychogeriatr.

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Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

Cited by 6 publications

References 16 publications

Performance on neuropsychological assessment and progression to dementia: A meta-analysis.

Performance on neuropsychological assessment and progression to dementia: A meta-analysis.

Improving the diagnosis and prediction of progression in mild cognitive impairment

Mild cognitive impairment: some steps forward

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