Interventions for managing taste disturbances

Abstract

Analysis 1.3. Comparison 1 Zinc versus placebo, Outcome 3 Taste acuity improvement for different taste sensations. Analysis 1.4. Comparison 1 Zinc versus placebo, Outcome 4 Taste acuity improvement-Cross-over study.. .. . Analysis 1.5. Comparison 1 Zinc versus placebo, Outcome 5 Taste acuity improvement-Objective outcome-Dichotomous.

The Pathophysiology and Management of Taste Changes in Chronic Kidney Disease: A Review

“…12 A decrease in salivary gustin causes taste and smell disorders. 13 Zinc also increases salivary calcium concentration 14 which allows taste buds to work properly. 15 Finally, zinc is a co-factor of alkaline phosphatase, a significant enzyme in the membrane of taste buds.…”

“…The authors of the Cochrane review of these studies concluded that, overall, there was ''limited evidence'' on the primary outcomes of taste acuity and discrimination and ''is not conclusive in demonstrating improvement in taste perception.'' 14 Empirical Treatment: Is There a Pathophysiological Basis for Efficacy?…”

Zinc Deficiency-induced Hypogeusia in a Patient with Refractory Iron-deficiency Anemia: A Case Report

“…It has been postulated that zinc supplementation may restore taste sensation in patients with both idiopathic and zinc deficiency-associated taste disturbances. Although the results of clinical trials have been inconsistent, a comprehensive Cochrane meta-analysis reveals some evidence to support the use of zinc supplementation to treat taste disturbances as measured by objective descriptors of taste acuity, particularly in zinc-deficient cohorts [3,[19][20]. Our zinc-deficient patient's chronic hypogeusia improved rapidly with zinc supplementation.…”

Persistent dysgeusia post-halitosis treatment: How does it impact the patients quality of life?

“…Total dysgeusia is defined as the inability to interpret all basic tastes which, in most cases, is associated with mineral deficiency (1). This condition can cause a loss of appetite and even malnutrition (2).…”

“…The inflammation caused by radiotherapy, smoking habit, zinc deficiency, drugs use, medications, chlorhexidine mouthrinse, xerostomia and nerve damage (chorda tympani or glossopharyngeal) can also cause dysgeusia (2,3). In addition, brain tumors, as well as psychiatric, depression and anxiety symptoms, can be associated with alterations in taste (4).…”