Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study

Canivell, Sílvia; Mohaupt, Markus; Ackermann, Daniel; Pruijm, Menno; Guessous, Idris; Ehret, Georg; Escher, Geneviève; Péchère-Bertschi, Antoinette; Vogt, Bruno; Devuyst, Olivier; Burnier, Michel; Martin, P. I. R.; Ponte, Belén; Bochud, Murielle

doi:10.1007/s40618-017-0807-7

Cited by 14 publications

(16 citation statements)

References 33 publications

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“…Nevertheless, other studies have found associations between copeptin and the metabolic factors related to IR in children and adolescents [18][19][20], but the associations found have overall been less consistent compared with the studies in adults [2][3][4][5][6][7][8]. We have no obvious explanation for this age-related discrepancy, but it is important in this connection that the well described negative association between insulin and IR and the natriuretic peptide system could not be found among our adolescents, either [39], and that others have also found that age modulates the association of copeptin with IR [40]. Accordingly, in a family-based crosssectional study, the association between copeptin and IR could only be found among the middle-aged and elderly but not among the younger adults [40].…”

Section: Adolescents Versus Young Adultscontrasting

confidence: 68%

“…We have no obvious explanation for this age-related discrepancy, but it is important in this connection that the well described negative association between insulin and IR and the natriuretic peptide system could not be found among our adolescents, either [39], and that others have also found that age modulates the association of copeptin with IR [40]. Accordingly, in a family-based crosssectional study, the association between copeptin and IR could only be found among the middle-aged and elderly but not among the younger adults [40]. We speculated that metabolic dysfunction could take some time to develop.…”

Section: Adolescents Versus Young Adultscontrasting

confidence: 62%

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Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

et al. 2019

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surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress. Peptides, 115,[8][9][10][11][12][13][14] Dette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du her: http://dx. ABSTRACTIn middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were logtransformed. Among the young adults, copeptin associated with IR (B (95%CI) =0.19 (0.11 to 0.27), P<0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P=0.78). MDI score associated with IR (B=0.010 (0.004 to 0.016), P<0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

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Section: Adolescents Versus Young Adultscontrasting

confidence: 68%

Section: Adolescents Versus Young Adultscontrasting

confidence: 62%

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

et al. 2019

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“…Elevated glucocorticoid level in blood is clinically characterized by the development of diabetes, insulin resistance and visceral adiposity. 20 ROC curve analysis in the present study revealed that copeptin could be an excellent undependable predictor of DM risk with a sensitivity of 90.0% and specificity of 66.7% (AUC; 0.841) compared to fasting blood glucose and HbA1c (AUC; 0.872 and 0.803, respectively). These results were in line with Zhu et al 15 Moreover, copeptin shows high sensitivity and specificity (90.0% and 73.3%, respectively) (AUC; 0.921) for diagnosis of nephropathic complications of type II DM.…”

Section: Discussionmentioning

confidence: 49%

Copeptin: Promising Biomarker for Nephropathy in Type II Diabetes

Ali

Al-Ashmawy

Aboelnasr

et al. 2020

Journal of Advanced Medical and Pharmaceutical Research

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Kidney injury is a dangerous diabetic microvascular complication responsible for the mortality of diabetics, which would require biomarkers for early detection of diabetic nephropathy. Copeptin, the C-terminal portion of vasopressin prohormone, is rapidly released in severe endogenous stress. So, the current work was carried out to evaluate and estimate copeptin as a marker for diabetic nephropathy. This cross-sectional work was conducted on 60 female and male type II diabetic cases. Diabetic cases were divided as normoalbuminuric (urinary albumin was <30 mg/24 h) without nephropathy and macroalbuminuric (urinary albumin was >300 mg/24 h) with nephropathy. The Control group was designated from fifteen matched healthy subjects. Controls and patients were evaluated for fasting blood glucose, glycosylated hemoglobin (HbA1c), urinary albumin, serum creatinine, and serum copeptin. Copeptin concentrations were significantly increased in type II diabetics with macroalbuminuria comparing to healthy controls and diabetics with normoalbuminuria. Serum copeptin concentrations were correlated positively with gold standard urinary albumin, serum creatinine, and HbA1c. Higher serum copeptin concentration in type II diabetics particularly in diabetics with nephropathy and its correlation with urinary albumin and HBA1c reflect the potential role of copeptin as a predictor of diabetes mellitus and development of diabetic nephropathy among type II diabetics considering other risk factors.

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“…However, our results should be interpreted in the context of risk-benefit considerations. Several of the previous approaches to improve insulin sensitivity involved the use of various medications (10,19,31) , which are not free from inadvertent side effects (9,32,33) . Although lifestyle modification with exercise is a must for people with diabetes, it is very difficult to achieve and maintain (34) .…”

Section: Discussionmentioning

confidence: 99%

“…AVP has also been shown to stimulate cortisol release through activation of the hypothalamus-pituitary-adrenal (H-P-A) axis, via V1b receptor expressed in the anterior pituitary, thus further influencing glucoregulatory mechanisms (5,6) . This unfamiliar role of AVP in glucose metabolism has been recently supported in several clinical studies showing that increased copeptin, the C-terminal part of the AVP precursor peptide (8) , used as a surrogate marker of AVP, was associated with increased risk of insulin resistance (IR) (9)(10)(11) , the metabolic syndrome (12)(13)(14) and diabetes (6,9,(15)(16)(17)(18) .…”

mentioning

confidence: 99%

Low hydration status may be associated with insulin resistance and fat distribution: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2010

Min

Kim

et al. 2020

Br J Nutr

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We aimed to identify the association of hydration status with insulin resistance (IR) and body fat distribution. A total of 14 344 adults participated in the Korea National Health and Nutrition Examination Survey 2008–2010. We used urine specific gravity (USG) to indicate hydration status, and HOMA-IR (homoeostasis model assessment of IR) and trunk:leg fat ratio (TLR) as primary outcomes. In multivariate logistic regression, the OR per 0·01 increase in USG for high IR was 1·303 (95 % CI 1·185, 1·433; P < 0·001). In multivariate generalised additive model plots, increased USG showed a J-shaped association with logarithmic HOMA-IR, with the lowest Akaike’s information criterion score of USG 1·030. Moreover, increased USG was independently associated with increased trunk fat, decreased leg fat and increased TLR. In mediation analysis, the proportion of mediation effects of USG on TLR via IR was 0·193 (95 % CI 0·132, 0·285; P < 0·001), while the proportion of mediation effects of USG on IR via TLR was 0·130 (95 % CI 0·086, 0·188; P < 0·001). Increased USG, a sign of low hydration status and presumably high vasopressin, was associated with IR and poor fat distribution. Direct effect of low hydration status may be more dominant than indirect effect via IR or fat distribution. Further studies are necessary to confirm our findings.

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Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study

Abstract: Our data suggest that age and apparent 11β-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes. Further research is needed to corroborate these results and to understand the mechanisms underlying these findings.

Cited by 14 publications

References 33 publications

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress

Copeptin: Promising Biomarker for Nephropathy in Type II Diabetes

Low hydration status may be associated with insulin resistance and fat distribution: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2010

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